Protein Alignment CREB3L1 and Atf6

DIOPT Version :10

• Sequence 1: NP_001412195.1
• Gene: CREB3L1 / 90993
• HGNCID: 18856
• Length: 557
• Species: Homo sapiens
• Sequence 2: NP_995745.1
• Gene: Atf6 / 35480
• FlyBaseID: FBgn0033010
• Length: 741
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 114/570 - (20%)
• Similarity: 200/570 - (35%)
• Gaps: 186/570 - (32%)

Human    24 DLNESDFLNNAHFPEHLDHFTENMEDFSNDLF------SSFFDDPVLDEKSPLLDMELDSPTPGI 82
            |:||.:..|:...   |...|||  ::.|::.      |:|::|..||         |....|.:
  Fly     2 DINEYNLYNDLSL---LGEVTEN--NYDNNIVHDILNSSAFYNDTSLD---------LSELIPDL 52

Human    83 QAEHSYSLSGDSAP-------QSPLVPIKMEDTTQDAEHGAWALGHKLCSIMVKQEQSP------ 134
            |.| ::.|...|.|       .||:..:|...:.              ||...|:..:.
  Fly    53 QKE-AFGLHFSSNPITSEFSLSSPISGLKQIPSA--------------CSGEFKRNVNDNNFQLD 102

Human   135 ------ELPVDPLAAP-------SAMAAAAAMATTPLL----GLSPLSRLPIPHQAPGE-----M 177
                  :|| :|.::|       :....:...|..|||    ...|... |...::|.:     :
  Fly   103 LTNSRNDLP-EPNSSPTRSLNRSNVNGCSNEEAVYPLLVDSDKFDPFFE-PAKVRSPNKEFNSTI 165

Human   178 TQLPVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSS----------PVR 232
            :.|..||.|..|.:|.|..             :|:.:..:.|...:|.|.::          .|.
  Fly   166 SNLSDIKNELPETSQDLGF-------------NSYNTSRNNSTLTKSWPINTELNLDNQVPKTVL 217

Human   233 PMARSSTAISTSPLLTAPHKLQGTSGPL--------------------LLTEEEKRTLIAEGYPI 277
            |::|:        :....|..:|....:                    ::.:::..|.|..   :
  Fly   218 PLSRT--------IYLPSHDYKGLLPTVKCNGDRTLKKNVNVRSKISNIVIKKKNATFIQS---L 271

Human   278 PTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENA 342
            ....|....::|..|:.:|.|||:.||..||:|:||||..||.::       |:|.|:.::|:..
  Fly   272 KESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRI-------NKLEKECDSLKAE 329

Human   343 NRTLLQQLQKLQT---------------------------LVTNKISRPYKMAATQT--GTCLMV 378
            |.||..|:..|.|                           ..|:|.....|...|.|  ....::
  Fly   330 NITLRDQIFLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSKAKHCNKNNTTATIKKNVAIL 394

Human   379 AALCFVLVL--GSLVPCL--PEFSSGSQTVKEDPLAADGVYTASQMPSRSLLFYDDGAGLWE-DG 438
            .|:.||:.|  |:....|  |....|...:  :|:...     ..|.:|.||:.|......| :.
  Fly   395 FAMAFVVSLNAGNFQKYLNIPNNLEGKSEI--EPVGKQ-----LSMSNRRLLWADSEEEYKEKNN 452

Human   439 RSTLL--PMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAW 486
            .||.|  ..:.|..:.:|.|          :::..::|....||.:|..:
  Fly   453 LSTFLSGKQKEPSLYFLNSG----------IRNHKINSFENITKNVSHTY 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREB3L1	NP_001412195.1	Required for transcriptional activation	1..60		11/41 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..98		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..259		9/68 (13%)
		bZIP_CREB3	291..344	CDD:269837	20/52 (38%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	292..321		16/28 (57%)
		coiled coil	293..344	CDD:269837	19/50 (38%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	332..353		7/20 (35%)
		MBTPS2 recognition. /evidence=ECO:0000303|PubMed:21767813	392..395		1/4 (25%)
		MBTPS1 recognition. /evidence=ECO:0000303|PubMed:21767813	423..426		1/2 (50%)
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	23/57 (40%)
		coiled coil	287..338	CDD:269848	23/57 (40%)