Protein Alignment KIFC2 and kifc1

DIOPT Version :10

• Sequence 1: NP_665697.1
• Gene: KIFC2 / 90990
• HGNCID: 29530
• Length: 838
• Species: Homo sapiens
• Sequence 2: XP_002938712.2
• Gene: kifc1 / 100038104
• XenbaseID: XB-GENE-489355
• Length: 650
• Species: Xenopus tropicalis
• Alignment Length: 694
• Identity: 201/694 - (28%)
• Similarity: 307/694 - (44%)
• Gaps: 182/694 - (26%)

Human    73 EGRAAAVSLEEALLRLAEFLSVQLGAEESCGGPADLGQSGEVPSLLTVTSQLLALLAWLRSPR-- 135
            :|:....|||      ||..:|::.|..:...|.                  .|.:|.|..|:
 Frog    40 KGKRLRSSLE------AELPTVRVAASIATSRPR------------------AAPIAALPKPQVI 80

Human   136 GRQALLQGTQPAPRVRPP-SPDGSTSQEESPSHFTAVPGEPLGDETQGQQPLQLEEDQR---AWQ 196
            |||:|..       :||. |..|.||        .|..|:| .......||..:..|::   ||.
 Frog    81 GRQSLAV-------IRPKNSIPGVTS--------AAFSGKP-KVSASATQPAAISGDKKKRAAWD 129

Human   197 RLEQLILGQLEELKQQLEQQEEELGRLRLGVGATDSEKRVQHLTLENEALKQSL-SLMRDLLLHW 260
                 :.||:.:::.::                |:.:.:||:|:.||..|:.|. .|:||:.:
 Frog   130 -----LKGQVSDMRDKV----------------TNYKGKVQNLSGENVRLQNSKDKLLRDVEM-- 171

Human   261 GPGPPIRAPQEEAEALLE---LQGRLQEAQDTTEALRAQ--------------LGVQEVQLQGLQ 308
                   ...|..:...|   |:.:|||.:....||..:              |..|.:.::.||
 Frog   172 -------LTSENTKLSKERCTLESQLQEVRQQVSALEREVARLTELCQRQEHTLSSQSISIEELQ 229

Human   309 GALQQLQQETEQNCRRELQQMHGQLAGLRARMASLRQGCGDLRGLVSTFTQSCQ------GSLSE 367
            ||...|   |:|...:::     :|..:.....||:....:....::..|.|..      .:|..
 Frog   230 GANTSL---TKQLLDKDV-----KLVCVSGENTSLKHTVKEQTDEIAALTVSVAEKDTEVHNLDT 286

Human   368 ARGQVSWALGALSSGGPGTQLPEGQQGPPAGCPGRLPELKGNIRVLCRLRPGTSSSLVSVEPGPG 432
            .|.::.                           ..:.||||||||.||:||    :|...:..|.
 Frog   287 ERRRLH---------------------------NLVQELKGNIRVFCRVRP----TLTQEKELPA 320

Human   433 GTVT---------------TCYRGRHRR------FRLDWVFPPDASQEEVFRELEPAVLSCLRGY 476
            |.::               ..:.||.::      |..|.||||..|||.||.|:...|.|.|.||
 Frog   321 GHISYPSNDDKAVVLSKMEESHVGREKKDAVKYDFNFDCVFPPSCSQESVFEEISLLVQSALDGY 385

Human   477 SVCIFTYGQTGTGKTYSMEGPPED-----PGIVPRALQSLF---REMGA-GRQHRVTLSMVEIYN 532
            .||||.|||||:||||:||| |||     .|::|||:..:|   .|:.| |.|...|.|.:||||
 Frog   386 PVCIFAYGQTGSGKTYTMEG-PEDITDDTIGMIPRAIGQIFSSAEELKAKGWQFTFTASFLEIYN 449

Human   533 EAVRDLLAPGPPERL--AVRQGPEGQGGIQVAGLTHWDVPNLETLHQMLKLGRSNRATAATAMNQ 595
            |.:||||...|.::|  .:|:.......:.|..|.:.:|.::|.:|.:|::.::||:.|.||:|.
 Frog   450 ETLRDLLINRPDKKLEYEIRKVNSSNSQLYVTNLRYVEVSSVEEVHDLLRIAKANRSVAKTAIND 514

Human   596 RSSRSHALVTLTLRAASPPRAPGTAGTLHLVDLAGSERARKAGAAGPPRGDPDGARRLREAQTIN 660
            ||||||::..|.:...:..|...|:..|.|:|||||||..::.::|.         ||:|.|.||
 Frog   515 RSSRSHSVFQLRIEGENKQRDLKTSSVLSLIDLAGSERLDRSLSSGD---------RLKETQCIN 570

Human   661 RSLLALGGVMAALRAHRPHVPFRDSQLTRLLQPALGPGTTAVLL 704
            .||..||.|:.:|.....|:|:|:|:||.|||.:|| |...||:
 Frog   571 TSLSTLGMVITSLCNKDSHIPYRNSKLTYLLQNSLG-GNAKVLM 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIFC2	NP_665697.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..48
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..185		10/45 (22%)
		Motor_domain	407..707	CDD:473979	131/330 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..792
kifc1	XP_002938712.2	Mplasa_alph_rch	<121..>287	CDD:275316	39/203 (19%)
		KISc_C_terminal	299..642	CDD:276817	131/330 (40%)