DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USP2 and not

DIOPT Version :9

Sequence 1:	NP_004196.4	Gene:	USP2 / 9099	HGNCID:	12618	Length:	605	Species:	Homo sapiens
Sequence 2:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	350	Identity:	123/350 - (35%)
Similarity:	171/350 - (48%)	Gaps:	35/350 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   265 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHH-GS-NAHTALVEEFAKLIQTIWT 327
            ||.||.|||.|||||.|:|.|.:|..|.||     :|.|.|. || ::|..||.|.::|.|..::
  Fly   156 GLRGLLNLGATCFMNCIVQALVHTPLLSDY-----FMSDRHDCGSKSSHKCLVCEVSRLFQEFYS 215

Human   328 SSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPD 392
            .| ...:|.......|..:|....||.||||.||....||.||    |..::.|:..|:..:...
  Fly   216 GS-RSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH----RHCVKAKAEHESKSNSSG 275

Human   393 DEKGRQMWRKYLEREDSR---------IGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKR 448
            ...|...     ....|.         |..:|.|.|:|.:.|..|...||.:|||||:||.:.:.
  Fly   276 SGSGTNS-----SNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGET 335

Human   449 ----GYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESR 509
                |....||:||:..:|:.:.|....|..|..|:..:...|:||::..|.::..|||||..|.
  Fly   336 TTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSA 400

Human   510 IRTSKLTTFVNFPLRDLDLREFASENTN---HAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWH 571
            :...|:::|:.||: :.|:..|.||..|   ...::||||.||.||...||||||.|.. ...|.
  Fly   401 LIDRKISSFIQFPV-EFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQ-KDTWV 463

Human   572 TFNDSSVTPMSSSQVRTSDAYLLFY 596
            ..:|..:|..|..||..|:.|||||
  Fly   464 KCDDHVITMASLKQVLDSEGYLLFY 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USP2	NP_004196.4	Necessary for interaction with MDM4. /evidence=ECO:0000269\|PubMed:19838211	1..200
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..264
		UCH	266..596	CDD:278850	120/347 (35%)
		Peptidase_C19R	268..597	CDD:239139	120/346 (35%)
		Necessary for interaction with MDM4. /evidence=ECO:0000269\|PubMed:19838211	403..503		32/112 (29%)
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	120/347 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940