DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBX18 and Doc2

DIOPT Version :10

Sequence 1:NP_001073977.1 Gene:TBX18 / 9096 HGNCID:11595 Length:607 Species:Homo sapiens
Sequence 2:NP_648282.1 Gene:Doc2 / 39038 FlyBaseID:FBgn0035956 Length:469 Species:Drosophila melanogaster


Alignment Length:503 Identity:169/503 - (33%)
Similarity:231/503 - (45%) Gaps:125/503 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   129 PGTPLPSPQ----APRVDLQGAE-------LWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPH 182
            |..|:|.|:    .|||.|.|.|       |||:||:|||||||||:||||||:||:.:|||:..
  Fly    35 PMLPIPMPRHVIMPPRVTLPGVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDE 99

Human   183 QQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKL 247
            ..|.:.:::||:.:.||:  :..|:|:.||.|:...|.|:|:||||||:|..|..|.|.|:|:||
  Fly   100 SNYCVLLEMVPIGDCRYK--FSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKL 162

Human   248 TNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQ 312
            |||.||:.|||:|.||||||||:||||.   .||:.|...|.    :||.|.||.|..||||||.
  Fly   163 TNNTLDNSGHIVLASMHKYQPRLHVIRT---ADLAQIPWAPQ----QAFVFAETEFVAVTAYQND 220

Human   313 QITRLKIDRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFED---IPGIPKQGNASSSTL 374
            :||:||||.||||||||::|::|..           |....:.|.||   .|.:....:.|.|.:
  Fly   221 RITKLKIDNNPFAKGFRETGQSRCK-----------RKMSSSPTGEDQDQSPSLSHSQSQSESDM 274

Human   375 LQGTGNGVPATHPHLLSGSSCSSPAFHLGPNTSQL------CSLAPA--DYSACARSGLTLNRYS 431
            ....|.|..|.....:..|.        ||...:|      |||:.:  |.|....|.|.|..  
  Fly   275 SPTKGGGETAGGTSSIGDSD--------GPQIKRLRSNGSACSLSSSLDDQSVPGASSLALGS-- 329

Human   432 TSLAETYNRLTNQAGETFAPPRTPSY-----VGVSSSTSVNMSMGGTDGDTFSCPQTSLSMQISG 491
                              .||...|:     :...|::||.|.            ....:|| |.
  Fly   330 ------------------PPPHLHSHSHPHPLQARSASSVFMQ------------HFQQNMQ-SL 363

Human   492 MSPQLQYIMPSPSSNAFATNQTHQGSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLG 556
            :.|.|..:    :...|.....:.|:.....::.|.|:........|.|                
  Fly   364 LRPSLVDL----ACTYFGRPHEYGGAIQASPMYPPAAMLQAGLGPHPGL---------------- 408

Human   557 SSPSGTMTDRQMLPP-VEGVHLLS--SGGQQSFFDSRTLGSLTLSSSQ 601
                       .||| |.|..|:|  ||.::...|   :||.|.:..|
  Fly   409 -----------NLPPGVSGADLISDESGAEELELD---VGSETSTLEQ 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBX18NP_001073977.1 Engrailed homology 1 repressor. /evidence=ECO:0000305 18..28
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..141 5/15 (33%)
PHA03307 <32..>139 CDD:223039 4/13 (31%)
Nuclear localization signal. /evidence=ECO:0000305 36..40
T-box_TBX15_18_22-like 137..330 CDD:410317 108/203 (53%)
Doc2NP_648282.1 T-box_Drosocross-like 56..238 CDD:410332 103/190 (54%)
Blue background indicates that the domain is not in the aligned region.

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