Protein Alignment TBX18 and org-1

DIOPT Version :10

• Sequence 1: NP_001073977.1
• Gene: TBX18 / 9096
• HGNCID: 11595
• Length: 607
• Species: Homo sapiens
• Sequence 2: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Alignment Length: 646
• Identity: 191/646 - (29%)
• Similarity: 273/646 - (42%)
• Gaps: 151/646 - (23%)

Human    43 AEEAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPP-AG----ATSGPARSGADLERGAAGGCED 102
            :..:..::.:..|.      ::.||......:||.. ||    |:..|...|..:...:|||.
  Fly    93 SNSSTSSISNPSCP------DQSSSSSSSSVSLPTDYAGVHSEASMAPTAGGTAVTTTSAGGV-- 149

Human   103 GFQQGASPLASPGGSPKGSPARSLARPGTPLPS----------PQAPR-----VDLQGAELWKRF 152
                 ::..||.....:.....:.|..||..|:          |..|.     |.|:...||.:|
  Fly   150 -----SASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIVVLETKALWDQF 209

Human   153 HEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSP 217
            |..||||||||.||||||..:|:|.|||||..|...||.||:|:|||||.:|:|.|:|||.||..
  Fly   210 HAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKADPI 274

Human   218 VPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLS 282
            .|||:::||||||.|..||:|::||||||||||:||:.|||||:|||:||||.|::       ..
  Fly   275 SPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLV-------YL 332

Human   283 PIKPVPSGEG-----VKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRMGLEALV 342
            |.|.....|.     .:.|.||||.||.|||||||::|:|||..|||||||||.|.|.:....
  Fly   333 PPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGTNDVTTGG-- 395

Human   343 ESYAFWRPSLRTLTFEDIPGIPKQGNASSSTLLQ----------------GTGNGVPATHPHLLS 391
                  ..|:.:::.|....:.:|.........|                .|.|          .
  Fly   396 ------GSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSN----------F 444

Human   392 GSSCSSPAFHLGPNTSQLCSL--APADYSACARSGLT---------------------------- 426
            |.|||..|........|...:  .||..|:.:.||.:
  Fly   445 GLSCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSPDLLGYQMEQQLQQQHQQQQQQQHQSQQ 509

Human   427 --------LNRYSTSLAETYNR------------------LTNQAGETFAPPRTPSYVGVSSSTS 465
                    .|:..:.|.::.|.                  ||..:..:.:||.|.: .|.|::|:
  Fly   510 QHLHQQHQANQQQSLLQQSQNHTQYGSYHHAYQAQVQSHPLTPHSSSSASPPATAA-PGASAATA 573

Human   466 V---NMSMGGTDGDTFSCPQTSLSMQISGM-SPQLQ------YIMPSPSSNAFATNQTHQGSYNT 520
            .   .....|..|.|.:....|.:...|.: .|..|      .|....::.|.|.:..|..::..
  Fly   574 AVAGGAGAAGAGGATSATQVMSAANIYSSIGQPYAQEQSNFGAIYHHNAAAAAAAHYHHGHAHGH 638

Human   521 FRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSS-PS--GTMTDRQMLPPVEGVHLL 578
            ...|:....:|...|...||..|.....::.|  :|:: ||  |:....||:.|...:.|:
  Fly   639 AHSHAHAHAHGPYASAYDKLKVSRHAAAAAYG--MGATYPSFYGSAAHHQMMRPNSYIDLV 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX18	NP_001073977.1	Engrailed homology 1 repressor. /evidence=ECO:0000305	18..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..141		21/117 (18%)
		PHA03307	<32..>139	CDD:223039	20/110 (18%)
		Nuclear localization signal. /evidence=ECO:0000305	36..40
		T-box_TBX15_18_22-like	137..330	CDD:410317	113/202 (56%)
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	112/196 (57%)