DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX18 and Tbx18

DIOPT Version :9

Sequence 1:	NP_001073977.1	Gene:	TBX18 / 9096	HGNCID:	11595	Length:	607	Species:	Homo sapiens
Sequence 2:	NP_001101643.1	Gene:	Tbx18 / 315870	RGDID:	1309856	Length:	612	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	567/613 - (92%)
Similarity:	574/613 - (93%)	Gaps:	7/613 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLGAEEAAGAVDDGGCSRGGGAGEKG 65
            |||||||||||||||||||||||||||||||||||||||||..|||||||||.||||||||.|..
  Rat     1 MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLATEEAAGAVDDAGCSRGGGAREHR 65

Human    66 SSEGDEGAALPPP-AGATSGPARSGADLE-----RGAAGGCEDGFQQGASPLASPGGSPKGSPAR 124
            .:|.||..|.||| ||:.||||||..|.|     ||.||.|||||.|||||||||||||||||..
  Rat    66 CTEADEDPAPPPPAAGSASGPARSCTDAERSCASRGPAGSCEDGFLQGASPLASPGGSPKGSPVP 130

Human   125 SLARPGTPLPSPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAM 189
            .|||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 GLARPGTPLPAPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAM 195

Human   190 DIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDD 254
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 DIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDD 260

Human   255 QGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKI 319
            |||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 QGHIILHSMHKYQPRVHIIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKI 325

Human   320 DRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNASSSTLLQGTGNGVPA 384
            |||||||||||||||||||||||||||||||||||||||||||||||||.|||.||.||||||||
  Rat   326 DRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNTSSSALLPGTGNGVPA 390

Human   385 THPHLLSGSSCSSPAFHLGPNTSQLCSLAPADYSACARSGLTLNRYSTSLAETYNRLTNQAGETF 449
            .||||||||||||||||||||||||||:|||||||||||||.||||||||||||||||||:.|||
  Rat   391 AHPHLLSGSSCSSPAFHLGPNTSQLCSMAPADYSACARSGLALNRYSTSLAETYNRLTNQSSETF 455

Human   450 APPRTPSYVGVSSSTSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPSPSSNAFATNQTH 514
            |||||||||.| ||.|||||||||||||||||||||||||||||||||||:|||||||||.||||
  Rat   456 APPRTPSYVSV-SSPSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIIPSPSSNAFAANQTH 519

Human   515 QGSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPSGTMTDRQMLPPVEGVHLLS 579
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
  Rat   520 QGSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPSGTMTDRQMLPPVEGVHLLG 584

Human   580 SGGQQSFFDSRTLGSLTLSSSQVSAHMV 607
            ||.|||||||||||||||||||||||||
  Rat   585 SGNQQSFFDSRTLGSLTLSSSQVSAHMV 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX18	NP_001073977.1	Engrailed homology 1 repressor. /evidence=ECO:0000305	18..28		9/9 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..141		86/116 (74%)
		Nuclear localization signal. /evidence=ECO:0000305	36..40		3/3 (100%)
		TBOX	139..334	CDD:238106	193/194 (99%)
Tbx18	NP_001101643.1	TBOX	145..340	CDD:238106	193/194 (99%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83691103
Domainoid	1	1.000	525	1.000	Domainoid score	I6429
eggNOG	1	0.900	-	-		E1_KOG3585
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11384
Inparanoid	1	1.050	1134	1.000	Inparanoid score	I4483
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40134
OrthoDB	1	1.010	-	-		D100293at32523
OrthoFinder	1	1.000	-	-		FOG0011543
OrthoInspector	1	1.000	-	-		oto130902
orthoMCL	1	0.900	-	-		OOG6_117338
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9220
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270