DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX18 and bi

DIOPT Version :9

Sequence 1:	NP_001073977.1	Gene:	TBX18 / 9096	HGNCID:	11595	Length:	607	Species:	Homo sapiens
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	202/640 - (31%)
Similarity:	278/640 - (43%)	Gaps:	154/640 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    72 GAALPPPAGATS---------------------------GPARSGADLERGAAGGCEDGFQQGAS 109
            ||| .||||||.                           .||.:.|.| .|:..|...|...|..
  Fly   208 GAA-APPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAAL-AGSPAGPHPGLYPGGG 270

Human   110 ---PLASPGGSPK----GSP---------ARSLARPGTPLPSP------------QAPRVDLQGA 146
               |...||..|.    ||.         |.::|....|...|            ..|:|.|:|.
  Fly   271 LRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEGK 335

Human   147 ELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVA 211
            :||::||::||||:|||:||:|||.|:.::||||...:|.:.:|||..|:  |||.:|:|:||||
  Fly   336 DLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADD--YRYKFHNSRWMVA 398

Human   212 GNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHI---ILHSMHKYQPRVHVI 273
            |.||..:|.|:|||||||.:||.||::|:||.|||||||..|..|.:   ||:||||||||.|::
  Fly   399 GKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRFHLV 463

Human   274 RKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGR-NRMG 337
            |      .:.|..:|... .:.:.|.||.|..||||||::||:||||.|||||||||:|. .|..
  Fly   464 R------ANDILKLPYST-FRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREK 521

Human   338 LEALVESYAFWRPSLRTLTFEDIPGIPKQGNASSSTLLQGTGNGVPATHPH--LLSGSSCSSPAF 400
            .:||:.:.......|.          |...::|.:.|..|.....|..|||  ||..........
  Fly   522 KQALMSNRGSDSDKLN----------PTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDDDDKL 576

Human   401 --HLGPNTSQLCSLAPADYSACARSGLTLNRYSTSLAETYNRL---------------TNQAGET 448
              .:||..|   .|.|..:|.   ..:..:::|.:||..:|.|               .|.:.|.
  Fly   577 LDVVGPPQS---PLLPLSHSL---QQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAED 635

Human   449 FAPPRTPSYVGV---SSSTSVNMSMGGTDGDTFSCPQTSLSMQISGM-----------------S 493
            ....|..:...|   .|.:|.:.|:||:.|..|....|....:..|.                 |
  Fly   636 ALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGAAAAAAAAGLNPGGGSYPS 700

Human   494 PQLQYIMP-SPSSNAFATNQTHQGSY---NTFRLHSPCALY---------GYNFSTSPKLAASPE 545
            |.:....| .||.:.......| |.|   :...||:|.|..         |..|:....|||...
  Fly   701 PNISVGPPIHPSPHLLPYLYPH-GLYPPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHP 764

Human   546 KIVSSQGSFLGSSPSGTMTDRQMLPPVEGV--HLLS----SGGQQSFFDSRTLGS 594
            .:.....:..|.:|         :.|::|:  |..|    .|...|.||:.|.||
  Fly   765 ALFGHAYAAAGHTP---------VSPLQGLKSHRFSPYSLPGSLGSAFDAVTPGS 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX18	NP_001073977.1	Engrailed homology 1 repressor. /evidence=ECO:0000305	18..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..141		28/123 (23%)
		Nuclear localization signal. /evidence=ECO:0000305	36..40
		TBOX	139..334	CDD:238106	107/198 (54%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	13/57 (23%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	103/191 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840