Protein Alignment ADCK2 and MCO76

DIOPT Version :9

• Sequence 1: NP_443085.2
• Gene: ADCK2 / 90956
• HGNCID: 19039
• Length: 626
• Species: Homo sapiens
• Sequence 2: NP_015216.3
• Gene: MCO76 / 855995
• SGDID: S000006030
• Length: 657
• Species: Saccharomyces cerevisiae
• Alignment Length: 556
• Identity: 174/556 - (31%)
• Similarity: 268/556 - (48%)
• Gaps: 128/556 - (23%)

Human   110 FFPLLLLYPLTYLAPSV------------STLWLHLLLKATETSGPTYIKLGQWASTRRDLFSEA 162
            |.|||||||:::....:            |.:|..||.||.|.:||::|||||||.:|.|:||.|
Yeast   129 FLPLLLLYPISWFGHKLKITDTNITETRGSLIWCQLLRKALELAGPSFIKLGQWAGSRTDIFSHA 193

Human   163 FCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWGSILSFE------NREPVGSGCVAQVYKAYANT 221
            .|.:..|||..||.|..:.|...|.||...|     ..|      ||.|:|.|.:||||....:.
Yeast   194 LCHELGKLHSNVTAHSLSFTLEKLSQALKVD-----KIEDAFDEFNRTPIGVGSIAQVYVGELSQ 253

Human   222 AFLET-DSVQ--RLGRASCLPPFSHTGAVGGLRELFGYLGNGRKPPENLADQSFLERLLLPKADL 283
            .:::. |::|  :.|...|
Yeast   254 KYIDKYDNIQIGKDGNRWC---------------------------------------------- 272

Human   284 VGSNAGVSRAQVPGHQPEATNLISVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPGIKWLSLPE 348
                                     |:|:|||.:.:|:..||.:||..:..:..:|.::|||||.
Yeast   273 -------------------------AIKILHPNVRSQIRRDLKIMKFCADAINWIPTMEWLSLPS 312

Human   349 IVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVP----VS 409
            .|::|..||..|:|||.||.|||.|..||:|...||||.|..|...|:|:.|.:...:.    :|
Yeast   313 EVDQFSILMNIQLDLRIEALNLERFNENFKNSIQVKFPKPFLPLSNRDVMFEEHVYGLSMEKFLS 377

Human   410 SYQQAGIPVDLKRKIARLGINMLLKMIFVDNFVHADLHPGNILVQ-------GANGLSSSQEA-- 465
            :.:|.. .|:|.:|::...::..|:|:.:|:||||||||||::::       |.|.:||..|:
Yeast   378 TKKQIN-DVELCKKVSDPFVDAFLQMLILDDFVHADLHPGNVIIRFVKTNKYGTNIISSELESYR 441

Human   466 ----------QLQQADICDTLVVAVPSSLCPLRLVLLDAGIVAELQAPDLRNFRAVFMAVVMGQG 520
                      :.|..|....| .:|.::..| ::..:|.||:.||...:..||.|:|.|:....|
Yeast   442 ITHDLRKKIEEDQDQDFVGKL-KSVLTNYTP-QICFIDTGIITELNEKNRINFIALFNALARFDG 504

Human   521 QRVAELILHHARASEC---RDVEGFKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTHKVK 582
            .|..||::..:|..|.   ::|..||.|  .||.:.::.|.||..:.:..||..:..::.:|.|:
Yeast   505 YRAGELMIERSRTPETAIDKEVFAFKVE--KLVDKVKQRTFTLGTVSIGDLLDQMLSMVRSHHVR 567

Human   583 LESNFASIVFAIMVLEGLGRSLDPKLDILEAARPFL 618
            :||:|.|:|.||::|||:||.|||.||:.|::.|.|
Yeast   568 MESDFVSVVVAILLLEGIGRQLDPNLDLFESSLPIL 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCK2	NP_443085.2	AarF	134..618	CDD:223733	162/518 (31%)
		ADCK2-like	169..553	CDD:270873	117/418 (28%)
MCO76	NP_015216.3	ADCK2-like	200..538	CDD:270873	117/418 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159046403
Domainoid	1	1.000	124	1.000	Domainoid score	I1366
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49103
Inparanoid	1	1.050	288	1.000	Inparanoid score	I614
Isobase	1	0.950	-	0	Normalized mean entropy	S2751
OMA	1	1.010	-	-		QHG55319
OrthoFinder	1	1.000	-	-		FOG0005065
OrthoInspector	1	1.000	-	-		oto145324
orthoMCL	1	0.900	-	-		OOG6_103424
Panther	1	1.100	-	-	LDO	PTHR45890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1989
SonicParanoid	1	1.000	-	-		X2125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740