DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK2 and Adck2

DIOPT Version :9

Sequence 1:	NP_443085.2	Gene:	ADCK2 / 90956	HGNCID:	19039	Length:	626	Species:	Homo sapiens
Sequence 2:	NP_849204.1	Gene:	Adck2 / 57869	MGIID:	1889336	Length:	617	Species:	Mus musculus

Alignment Length:	622	Identity:	464/622 - (74%)
Similarity:	513/622 - (82%)	Gaps:	9/622 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVAPWRVSVRVCLSHLRCFELRQGLSLLRPSECPRDARLCWLLLGTLPKVVSLCGDVGEGAPDVL 65
            ||.|||:|||||||||||||.|:.|...||..|.|:|||||.|||||||::|..|.||||||..|
Mouse     1 MVTPWRLSVRVCLSHLRCFEFRKELGHSRPLGCSRNARLCWFLLGTLPKLISAHGSVGEGAPGSL 65

Human    66 SRRRVRCSGAAGAGPAESLPRAGPLGGVFLHLRLWLRAGALLVKFFPLLLLYPLTYLAPSVSTLW 130
            .:|:...|..|..|..|.:.:.|||..|.|.|||.||||.||.||||||.|||||||||.:||||
Mouse    66 CQRKTHWSDLAENGLVEKVAQEGPLARVLLCLRLGLRAGVLLAKFFPLLFLYPLTYLAPGLSTLW 130

Human   131 LHLLLKATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWG 195
            ||||.|||||||||||||||||||||||||||||.|||||||:||||||..||..|:||||:|||
Mouse   131 LHLLFKATETSGPTYIKLGQWASTRRDLFSEAFCTQFSKLHVQVTPHPWARTEYLLQQAFGEDWG 195

Human   196 SILSFENREPVGSGCVAQVYKAYANTAFLETDSVQRLGRASCLPPFSHTGAVGGLRELFGYLGNG 260
            |:|.||.|||||||||||||||:|:.:.||.|.:.|||..|.    ..|.||...||.|   ...
Mouse   196 SLLFFETREPVGSGCVAQVYKAFASISLLEEDRIWRLGELSA----PGTRAVVMQREPF---MKD 253

Human   261 RKPPENLADQSFLERLLLPKADLVGSNAGVSRAQVPGHQPEATNLISVAVKVLHPGLLAQVHMDL 325
            |||.|||||::|||:||||||||.||..|||  |.|.|.|::.:||.|||||||||||:||.|||
Mouse   254 RKPSENLADEAFLEKLLLPKADLGGSEVGVS--QAPWHLPKSDHLIPVAVKVLHPGLLSQVSMDL 316

Human   326 LLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLR 390
            |||||||:.||:|||:|||||||||||||||||||.|||||||||||||.||:::.:||||||||
Mouse   317 LLMKIGSKALGLLPGVKWLSLPEIVEEFEKLMVQQTDLRYEAQNLEHFQHNFQDMASVKFPTPLR 381

Human   391 PFVTREVLVETYEESVPVSSYQQAGIPVDLKRKIARLGINMLLKMIFVDNFVHADLHPGNILVQG 455
            |.:||::||||||||||||||||||||.|||||||:|||||||||||||||||.|||||||||||
Mouse   382 PLITRDILVETYEESVPVSSYQQAGIPTDLKRKIAQLGINMLLKMIFVDNFVHGDLHPGNILVQG 446

Human   456 ANGLSSSQEAQLQQADICDTLVVAVPSSLCPLRLVLLDAGIVAELQAPDLRNFRAVFMAVVMGQG 520
            |:|:|.|.|.|.||.::|||||..:..:|||||||||||||||:|||.|||||||||.|||||||
Mouse   447 ADGVSPSLEMQQQQVNVCDTLVATIAPALCPLRLVLLDAGIVAKLQASDLRNFRAVFQAVVMGQG 511

Human   521 QRVAELILHHARASECRDVEGFKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTHKVKLES 585
            .|||||:||||:|:||:|||.||.|||.||||||||.:|||||||||||||||||||||||||||
Mouse   512 HRVAELMLHHAQANECKDVERFKAEMATLVTQARKNIVTLEKLHVSSLLSSVFKLLMTHKVKLES 576

Human   586 NFASIVFAIMVLEGLGRSLDPKLDILEAARPFLLTGP 622
            ||||||.||||||||||||||.|||||||:|||..||
Mouse   577 NFASIVVAIMVLEGLGRSLDPTLDILEAAKPFLFKGP 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK2	NP_443085.2	AarF	134..618	CDD:223733	374/483 (77%)
ADCK2	NP_443085.2	ADCK2-like	169..553	CDD:270873	281/383 (73%)
Adck2	NP_849204.1	UbiB	98..609	CDD:273909	404/519 (78%)
Adck2	NP_849204.1	ADCK2-like	169..544	CDD:270873	281/383 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83953335
Domainoid	1	1.000	385	1.000	Domainoid score	I11926
eggNOG	1	0.900	-	-		E1_COG0661
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49103
Inparanoid	1	1.050	900	1.000	Inparanoid score	I6805
Isobase	1	0.950	-	0	Normalized mean entropy	S2751
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55319
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005065
OrthoInspector	1	1.000	-	-		oto120722
orthoMCL	1	0.900	-	-		OOG6_103424
Panther	1	1.100	-	-	LDO	PTHR45890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1989
SonicParanoid	1	1.000	-	-		X2125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.240