DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK2 and Adck2

DIOPT Version :9

Sequence 1:	NP_443085.2	Gene:	ADCK2 / 90956	HGNCID:	19039	Length:	626	Species:	Homo sapiens
Sequence 2:	XP_008761004.1	Gene:	Adck2 / 312258	RGDID:	1311058	Length:	641	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	414/581 - (71%)
Similarity:	469/581 - (80%)	Gaps:	10/581 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVAPWRVSVRVCLSHLRCFELRQGLSLLRPSECPRDARLCWLLLGTLPKVVSLCGDVGEGAPDVL 65
            ||.|||:|||||||||||||..:.|.|.||..|.|:|||||.|||.|||.:|..|.|||.||..|
  Rat     1 MVNPWRLSVRVCLSHLRCFEFGKELGLSRPLGCSRNARLCWFLLGALPKFISAQGSVGEAAPGSL 65

Human    66 SRRRVRCSGAAGAGPAESLPRAGPLGGVFLHLRLWLRAGALLVKFFPLLLLYPLTYLAPSVSTLW 130
            .:|:...|.....|..: :.:.|||..:.|.|.|.||||.||.||.|||.|||||||||..||||
  Rat    66 CQRKTHWSNLPENGLVK-VAQEGPLARILLCLCLGLRAGVLLAKFLPLLFLYPLTYLAPGFSTLW 129

Human   131 LHLLLKATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWG 195
            ||||.|||||||||||||||||||||||||||||.|||||||:||||||..||..|:||||:||.
  Rat   130 LHLLFKATETSGPTYIKLGQWASTRRDLFSEAFCVQFSKLHVQVTPHPWARTEYLLQQAFGEDWH 194

Human   196 SILSFENREPVGSGCVAQVYKAYANTAFLETDSVQRLGRASCLPPFSHTGAVGGLRELFGYLGNG 260
            |||.||.:||||||||||||||:||.:.||...:.|||..| :|   .||.||..|:.|   ...
  Rat   195 SILFFETQEPVGSGCVAQVYKAFANISLLEKGRIWRLGELS-VP---GTGTVGTQRDPF---MKD 252

Human   261 RKPPENLADQSFLERLLLPKADLVGSNAGVSRAQVPGHQPEATNLISVAVKVLHPGLLAQVHMDL 325
            .:|.|||||::|:|:|||||||||.|..|||  |.||..|::.:||.|||||||||||:||::||
  Rat   253 WRPSENLADETFIEKLLLPKADLVRSEVGVS--QAPGQPPKSDHLIPVAVKVLHPGLLSQVYIDL 315

Human   326 LLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLR 390
            |||||||:.||::||:|||||||||||||||||||.|||||||||||||.||:|:.:|||||||.
  Rat   316 LLMKIGSQALGLIPGVKWLSLPEIVEEFEKLMVQQTDLRYEAQNLEHFQHNFQNMASVKFPTPLH 380

Human   391 PFVTREVLVETYEESVPVSSYQQAGIPVDLKRKIARLGINMLLKMIFVDNFVHADLHPGNILVQG 455
            |.:||::||||||||||||||||||:|.|||||||:||||||.||||||||||.|||||||||||
  Rat   381 PLITRDILVETYEESVPVSSYQQAGVPTDLKRKIAQLGINMLFKMIFVDNFVHGDLHPGNILVQG 445

Human   456 ANGLSSSQEAQLQQADICDTLVVAVPSSLCPLRLVLLDAGIVAELQAPDLRNFRAVFMAVVMGQG 520
            |:|:|||.|.|.||.|:.||||..:..:|||||||||||||||:|||.|||||||||:||.||||
  Rat   446 ADGVSSSLEMQQQQVDVYDTLVATIAPALCPLRLVLLDAGIVAKLQASDLRNFRAVFLAVAMGQG 510

Human   521 QRVAELILHHARASECRDVEGFKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTHKV 581
            .|||||:||||:|:||:|||.||.|||.|||||||||:||||||||||||||||||||||:
  Rat   511 HRVAELMLHHAQANECKDVEKFKAEMATLVTQARKNTLTLEKLHVSSLLSSVFKLLMTHKI 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK2	NP_443085.2	AarF	134..618	CDD:223733	335/448 (75%)
ADCK2	NP_443085.2	ADCK2-like	169..553	CDD:270873	274/383 (72%)
Adck2	XP_008761004.1	AarF	133..>518	CDD:223733	289/393 (74%)
Adck2	XP_008761004.1	ADCK2-like	168..543	CDD:270873	274/383 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83678810
Domainoid	1	1.000	385	1.000	Domainoid score	I11336
eggNOG	1	0.900	-	-		E1_COG0661
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49103
Inparanoid	1	1.050	874	1.000	Inparanoid score	I6681
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55319
OrthoDB	1	1.010	-	-		D116997at9347
OrthoFinder	1	1.000	-	-		FOG0005065
OrthoInspector	1	1.000	-	-		oto136985
orthoMCL	1	0.900	-	-		OOG6_103424
Panther	1	1.100	-	-	LDO	PTHR45890
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2125
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270