DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK2 and adck2

DIOPT Version :9

Sequence 1:	NP_443085.2	Gene:	ADCK2 / 90956	HGNCID:	19039	Length:	626	Species:	Homo sapiens
Sequence 2:	XP_002941660.3	Gene:	adck2 / 100486101	XenbaseID:	XB-GENE-959153	Length:	683	Species:	Xenopus tropicalis

Alignment Length:	576	Identity:	320/576 - (55%)
Similarity:	395/576 - (68%)	Gaps:	60/576 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    73 SGAAG-----AGPAESLPRAGPLGG----VFLHLRLWLRAGALLVKFFPLLLLYPLTYLAPSVST 128
            |.|||     .|| :.:||.||.|.    :|: ||:.:|:|.|.:||.|||||||||:::..:::
Frog   131 SEAAGPLRQEQGP-QPIPRQGPPGALTRIIFI-LRMGVRSGVLFLKFGPLLLLYPLTFVSAGLAS 193

Human   129 LWLHLLLKATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDD 193
            |||.|||||||||||..||||||||||||||||.||..||||||:||||||.:|||.|.:|||..
Frog   194 LWLRLLLKATETSGPACIKLGQWASTRRDLFSEDFCNLFSKLHVKVTPHPWEYTERCLHRAFGTH 258

Human   194 WGSILSFENREPVGSGCVAQVYKAYANTAFLE-------TDSVQRLGRASCLPPFSHTG----AV 247
            |..:|.|.:|||||||||||||||:|:.:.:.       |||..:          ..||    .|
Frog   259 WNRVLRFHSREPVGSGCVAQVYKAHADLSTIGQFDPQALTDSYDQ----------EMTGYEAWEV 313

Human   248 GGLRELFGYLGNGRKPPENLADQSFLERLLLPKADLVGSNAGVSRAQVPGHQPEAT--------- 303
            .||..:.|||...||                   .:|.|:.....:....|..|:|
Frog   314 PGLTGILGYLWEWRK-------------------KVVPSDRSGRASDQQQHPQESTLYPDGSDTQ 359

Human   304 NLISVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQ 368
            .||.||||||||||...|.||:||||..||::|.:||.:||||.|:||||||||..|||||.||:
Frog   360 QLIPVAVKVLHPGLTQHVRMDILLMKTWSRLIGWIPGFRWLSLTEMVEEFEKLMTHQIDLRSEAR 424

Human   369 NLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVSSYQQAGIPVDLKRKIARLGINMLL 433
            |||.|:..|..|..::|||||||.|||.:||||:|:..|||.|.:......:|::||.:|::|||
Frog   425 NLELFRQKFDKVDFIRFPTPLRPLVTRNILVETFEDGEPVSLYLREPDAAPIKQRIAGMGVDMLL 489

Human   434 KMIFVDNFVHADLHPGNILVQGANGLSSSQEAQLQQADICDTLVVAVPSSLCPLRLVLLDAGIVA 498
            ||||.|||||||||||||||||.:..::....|....|:||||:|.|....||||||:|||||||
Frog   490 KMIFTDNFVHADLHPGNILVQGVHQYATGAADQTTLVDMCDTLIVDVRPVRCPLRLVVLDAGIVA 554

Human   499 ELQAPDLRNFRAVFMAVVMGQGQRVAELILHHARASECRDVEGFKTEMAMLVTQARKNTITLEKL 563
            :||..||:|.||||.||::|||:.|||||||||||::|.||||:|.:||.|||:|||.|:.|.||
Frog   555 QLQEKDLQNLRAVFTAVLLGQGETVAELILHHARANQCTDVEGYKKDMAELVTEARKTTVALGKL 619

Human   564 HVSSLLSSVFKLLMTHKVKLESNFASIVFAIMVLEGLGRSLDPKLDILEAARPFLL 619
            .|:.|||.||::|||:||||||||||::||:||||||||||||::||||||||.||
Frog   620 QVAVLLSRVFQILMTYKVKLESNFASVIFAVMVLEGLGRSLDPEVDILEAARPLLL 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK2	NP_443085.2	AarF	134..618	CDD:223733	286/503 (57%)
ADCK2	NP_443085.2	ADCK2-like	169..553	CDD:270873	208/403 (52%)
adck2	XP_002941660.3	PTZ00436	<37..143	CDD:185616	4/11 (36%)
adck2	XP_002941660.3	ADCK2-like	234..609	CDD:270873	208/403 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	301	1.000	Domainoid score	I9261
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H49103
Inparanoid	1	1.050	577	1.000	Inparanoid score	I6719
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1299789at2759
OrthoFinder	1	1.000	-	-		FOG0005065
OrthoInspector	1	1.000	-	-		oto154086
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060