DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ESAM and side-II

DIOPT Version :9

Sequence 1:	NP_620411.2	Gene:	ESAM / 90952	HGNCID:	17474	Length:	390	Species:	Homo sapiens
Sequence 2:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster

Alignment Length:	339	Identity:	71/339 - (20%)
Similarity:	116/339 - (34%)	Gaps:	118/339 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    34 HLPANRLQAVEGGEVVLPAWYTLHGEVSSSQPWE-VPFVMWF------------FKQKEKEDQVL 85
            |:....:.||||..|.||...|        :|.: |..|:||            .:.||..:|..
  Fly    51 HVKTKDIDAVEGKSVSLPCPIT--------EPLDNVYMVLWFRDNAGIPLYSFDVRDKESREQPR 107

Human    86 SYINGVTTSKP---GVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLEL 147
            .:      |.|   |....:...|:..:|.   ::..|.|.|.|.|:.:..|.:|     ....|
  Fly   108 HW------SAPEVFGSRAKFHFDSQPATLE---IKRHDQGIYRCRVDFRTSQTQS-----FRFNL 158

Human   148 NVLVPPAPP------SCRLQGV----PHVGANVTLSCQSPRSKPAVQYQW-------DRQLPSFQ 195
            :|::.|..|      ..:|.|.    ...|.::.::|:....:|..|.:|       |.|...
  Fly   159 SVIILPEQPIIMDRWGRQLNGTQLGPKQEGDDIVITCRVVGGRPQPQVRWLVNGLLVDNQNEH-- 221

Human   196 TFFAPALDVIRGSLSLTNLS-SSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLV 259
                .:.|||...|...::. :.:..|:.|:|.|    .|.:...|.|
  Fly   222 ----NSGDVIENRLLWPSVQRNDLNSVFTCQALN----TQLDKPKEKS----------------- 261

Human   260 GLGLLAGLVLLYHRRG---KALEEPANDI--------------KEDAIAPRTLPWPK-------S 300
                   .:|..|.:.   |.||.|::.|              :.:||    :.|.|       :
  Fly   262 -------FILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGSRPNAI----ITWYKGKRQLRRT 315

Human   301 SDTISKNGTLSSVT 314
            .|.||||.|.|.::
  Fly   316 KDDISKNSTRSELS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ESAM	NP_620411.2	V-set	40..150	CDD:311561	29/125 (23%)
		IG_like	166..241	CDD:214653	16/82 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..368
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	29/126 (23%)
		Ig	57..160	CDD:299845	29/124 (23%)
		Ig	188..251	CDD:299845	14/68 (21%)
		Ig	289..363	CDD:299845	11/45 (24%)
		IG_like	289..351	CDD:214653	11/45 (24%)
		Ig_2	376..460	CDD:290606
		IG_like	383..454	CDD:214653
		Ig	470..548	CDD:299845
		IG_like	481..557	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910