DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ESAM and him-4

DIOPT Version :9

Sequence 1:	NP_620411.2	Gene:	ESAM / 90952	HGNCID:	17474	Length:	390	Species:	Homo sapiens
Sequence 2:	NP_001024582.1	Gene:	him-4 / 181187	WormBaseID:	WBGene00001863	Length:	5198	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	80/373 - (21%)
Similarity:	122/373 - (32%)	Gaps:	146/373 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    87 YING------------------VTTSKPGVSLVYSMPSRNL-------SLRLEGLQEKDSGPYSC 126
            ||||                  .:.||.||.|   :||.||       .:::...:..|.|.|||
Worm  4236 YINGSEGTETVIKCEIESESSEFSWSKNGVPL---LPSNNLIFSEDYKLIKILSTRLSDQGEYSC 4297

Human   127 SVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQ-SPRSKPAVQYQWDRQ 190
            :.      ....|::.:...|||.|.|.........|.|.|..|||.|: |...:||:.:..|.:
Worm  4298 TA------ANKAGNATQKTNLNVGVAPKIMERPRTQVVHKGDQVTLWCEASGVPQPAITWYKDNE 4356

Human   191 LPSFQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTL-------------EVS 242
            |.: .|.........:.|:..:::|.|.||||.|||.|.|.:.:.::.|             .||
Worm  4357 LLT-NTGVDETATTKKKSVIFSSISPSQAGVYTCKAENWVASTEEDIDLIVMIPPEVVPERMNVS 4420

Human   243 TGPGAAVVAGA---------------------------VVGTLVGL-GLLAGLVLLYH------- 272
            |.|...|....                           ::||.:.: .:|......||
Worm  4421 TNPRQTVFLSCNATGIPEPVISWMRDSNIAIQNNEKYQILGTTLAIRNVLPDDDGFYHCIAKSDA 4485

Human   273 --------------------------RRGKALEE-----------------PANDIKED----AI 290
                                      .:||..:.                 |..|:::.    :|
Worm  4486 GQKIATRKLIVNKPSDRPAPIWVECDEKGKPKKTEYMIDRGDTPDDNPQLLPWKDVEDSSLNGSI 4550

Human   291 APRTLPWPKSSDTI-----------SKNGT--LSSVTSAR--ALRPPH 323
            |.|.:|.|:||.|:           .||.|  :.::...|  |..|||
Worm  4551 AYRCMPGPRSSRTVLLHAAPQFIVKPKNTTAAIGAIVELRCSAAGPPH 4598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ESAM	NP_620411.2	V-set	40..150	CDD:311561	21/87 (24%)
		IG_like	166..241	CDD:214653	24/88 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..368		5/10 (50%)
him-4	NP_001024582.1	IG_like	442..515	CDD:214653
		IG	527..605	CDD:214652
		Ig	628..694	CDD:319273
		I-set	702..789	CDD:369462
		I-set	793..881	CDD:369462
		Ig	899..974	CDD:386229
		I-set	1012..1081	CDD:369462
		Ig	1109..1172	CDD:319273
		Ig	1196..1263	CDD:319273
		IG_like	1277..1358	CDD:214653
		I-set	1373..1450	CDD:369462
		Ig	1474..1544	CDD:386229
		IGc2	1563..1628	CDD:197706
		Ig	1651..1732	CDD:386229
		Ig	1755..1818	CDD:319273
		Ig	1839..1912	CDD:386229
		Ig	1930..2002	CDD:386229
		IG_like	2014..2095	CDD:214653
		Ig	2094..2182	CDD:386229
		Ig	2190..2283	CDD:386229
		I-set	2296..2380	CDD:369462
		Ig	2384..2471	CDD:386229
		IGc2	2492..2556	CDD:197706
		Ig	2580..2654	CDD:386229
		Ig	2686..2753	CDD:319273
		IG_like	2768..2850	CDD:214653
		I-set	2854..2939	CDD:369462
		IG_like	2951..3031	CDD:214653
		I-set	3046..3116	CDD:369462
		I-set	3127..3213	CDD:369462
		Ig	3217..3292	CDD:386229
		I-set	3300..3386	CDD:369462
		I-set	3396..3472	CDD:369462
		I-set	3481..3569	CDD:369462
		I-set	3591..3663	CDD:369462
		Ig	3667..3762	CDD:386229
		Ig	3775..3848	CDD:386229
		Ig	3859..3947	CDD:386229
		IGc2	3968..4031	CDD:197706
		Ig_3	4045..4119	CDD:372822
		Ig_3	4136..4210	CDD:372822
		Ig	<4262..4314	CDD:386229	15/60 (25%)
		Ig	4318..4406	CDD:386229	27/88 (31%)
		IG_like	4418..4496	CDD:214653	10/77 (13%)
		I-set	4570..4654	CDD:369462	8/29 (28%)
		I-set	4752..4836	CDD:369462
		EGF_CA	4996..5027	CDD:238011
		EGF_CA	5034..5076	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910