DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ESAM and ncam-1

DIOPT Version :9

Sequence 1:	NP_620411.2	Gene:	ESAM / 90952	HGNCID:	17474	Length:	390	Species:	Homo sapiens
Sequence 2:	NP_741709.1	Gene:	ncam-1 / 180418	WormBaseID:	WBGene00017184	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	328	Identity:	81/328 - (24%)
Similarity:	123/328 - (37%)	Gaps:	72/328 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    35 LPANRLQAVEGGEVVLPAWYTLHGEVSSSQ---PWEVPFV--MWFFKQKEKE------------- 81
            |..||.:..:||:      ||...|:...|   ..|:.||  ..|...:|.:
Worm   111 LMINRPKISDGGK------YTCKTEIQGEQQEVSAEISFVDPPKFLNVQESQHPEEGTRAEIVCE 169

Human    82 ----DQ--VLSYINGVT---TSKPGVSLVYSMPSRNLSLRLEGL-QEKDSGPYSCSVNVQDKQGK 136
                ||  |....||||   ||:.|    |.....|..|.:... .:||.|.|:|:.
Worm   170 VEGTDQLEVFWQFNGVTLDETSQRG----YEFSENNQILYIPHFTAKKDDGIYNCNA-------- 222

Human   137 SRGHSIKTLELNVLVPPAPPSCRLQGVPH-----VGANVTLSCQSPRSKPAVQYQW---DRQLPS 193
            ::..|.:||.:|| ...|.|:..:..||:     .|..:.|.|.:. .||...|:|   |.::|.
Worm   223 AQYSSFETLSVNV-TGYARPTITVFDVPNGNRGIEGHTIELKCGAV-GKPKPTYKWFFEDDEVPI 285

Human   194 FQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTL 258
            .:   :...:|..|.|.:.:|:|..||.|.|.|:|.||:.:....|.|...|...:....||..
Worm   286 AR---SDKHNVEEGLLIIESLNSEDAGTYKCVANNTVGSNERTFDLAVFLKPKVDLKHEYVVKE- 346

Human   259 VGLGLLAGLVLLYHRRGKALEEPANDIKEDAIAPRTL---------PWPKSSDTISKNGTLSSVT 314
               |....||..||..|....:..:...|.|:....:         |....|:.::.....|..|
Worm   347 ---GDDVELVCSYHGEGHVTAKFVSGHSEFAVRNEAVSAGNSEEIRPESNESEEVTTTSENSEET 408

Human   315 SAR 317
            |.:
Worm   409 STQ 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ESAM	NP_620411.2	V-set	40..150	CDD:311561	33/137 (24%)
		IG_like	166..241	CDD:214653	23/77 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..368		0/2 (0%)
ncam-1	NP_741709.1	IG	64..142	CDD:214652	10/36 (28%)
		Ig	69..140	CDD:143165	9/34 (26%)
		IG_like	153..236	CDD:214653	24/95 (25%)
		Ig	160..222	CDD:299845	18/65 (28%)
		IG_like	256..330	CDD:214653	23/77 (30%)
		IGc2	256..320	CDD:197706	20/67 (30%)
		IG_like	<445..499	CDD:214653
		Ig	<445..498	CDD:143165
		IG_like	520..596	CDD:214653
		IGc2	520..587	CDD:197706
		FN3	<652..701	CDD:238020
		FN3	<817..873	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910