Protein Alignment PYGO2 and pygo2

DIOPT Version :10

• Sequence 1: NP_612157.1
• Gene: PYGO2 / 90780
• HGNCID: 30257
• Length: 406
• Species: Homo sapiens
• Sequence 2: XP_031746422.1
• Gene: pygo2 / 779930
• XenbaseID: XB-GENE-6454464
• Length: 390
• Species: Xenopus tropicalis
• Alignment Length: 417
• Identity: 280/417 - (67%)
• Similarity: 309/417 - (74%)
• Gaps: 38/417 - (9%)

Human     1 MAASAPPPPDKLEGGGGPAPPPAPPSTGRKQGKAGLQMKSPEKKRRKSNTQGPAYSHLTEFAPPP 65
            |||.    .|||:|...|         ||: .|.|:||||||||||||||||||||||:||||||
 Frog     1 MAAD----QDKLDGLTLP---------GRR-AKTGMQMKSPEKKRRKSNTQGPAYSHLSEFAPPP 51

Human    66 TPMVDHLVASNPFEDDFGAPKVGVAA-PPFLGSPVPFGGFRVQGGMAGQVPPGYSTGGGGGPQPL 129
            ||||||||||||||||||||||..|| .|||.:|||||.:|:||||..|:.|||.    |||||:
 Frog    52 TPMVDHLVASNPFEDDFGAPKVNAAASSPFLNNPVPFGNYRMQGGMPHQMAPGYP----GGPQPI 112

Human   130 RRQPPPFPPNPMGPAFNMPPQGPGYPPPGNMNFPSQPFNQPLGQNFSPPSGQMMPGPVGGFGPMI 194
            |||.||||||.|.|.|.| .|.|.|..||||||.:.||||.:||:||||:|||:.|||||||||:
 Frog   113 RRQAPPFPPNQMAPGFAM-SQNPNYHQPGNMNFSNPPFNQAMGQSFSPPAGQMIQGPVGGFGPMM 176

Human   195 SPTMGQPPRAELGP---------PSLSQRFAQPGAPFGPSPLQRPGQGLPSLPPNTSPFPGPDPG 250
            ||.||||||.|:||         |..||||...|.|||..|:.|     ||||||||||.|.|..
 Frog   177 SPNMGQPPRGEMGPGPVLNSPGGPPFSQRFGPSGHPFGQPPVPR-----PSLPPNTSPFAGADQS 236

Human   251 FPGPGGEDGGKPLNPPASTAFPQEPHSGSPAAAVNGNQPSFPPNSSGRG-GGTPDANSLAPPGKA 314
            || ||.|:.||.:|||::| |.||.|.||| :|||||||:|.||:|.|| ..||:.|::.||.|.
 Frog   237 FP-PGVEEHGKNINPPSNT-FTQEQHVGSP-SAVNGNQPNFTPNNSARGNSSTPEVNNIPPPSKP 298

Human   315 GGGSGPQPPPGLVYPCGACRSEVNDDQDAILCEASCQKWFHRECTGMTESAYGLLTTEASAVWAC 379
            .|.||.||||||:||||||..|||||||||||||||||||||||||||||||.|||.|.||||||
 Frog   299 TGNSGHQPPPGLIYPCGACEREVNDDQDAILCEASCQKWFHRECTGMTESAYSLLTREVSAVWAC 363

Human   380 DLCLKTKEIQSVYIREGMGQLVAANDG 406
            |.|||||:|||||||..||||||||||
 Frog   364 DYCLKTKDIQSVYIRGAMGQLVAANDG 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PYGO2	NP_612157.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		46/71 (65%)
		Nuclear localization signal. /evidence=ECO:0000255	41..47		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..323		132/226 (58%)
		PHD_PYGO2	329..382	CDD:277106	47/52 (90%)
pygo2	XP_031746422.1	Cytadhesin_P30	<83..201	CDD:429374	74/122 (61%)
		PHD_PYGO2	313..366	CDD:277106	47/52 (90%)