Protein Alignment PYGO2 and pygo2

DIOPT Version :10

• Sequence 1: NP_612157.1
• Gene: PYGO2 / 90780
• HGNCID: 30257
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_001028283.2
• Gene: pygo2 / 613247
• ZFINID: ZDB-GENE-050809-108
• Length: 571
• Species: Danio rerio
• Alignment Length: 577
• Identity: 225/577 - (38%)
• Similarity: 258/577 - (44%)
• Gaps: 214/577 - (37%)

Human    30 KQGKAGLQMKSPEKKRRKSNTQGPAYSHLTEFAPPPTPMVDHLVASNPFEDDFGAP--KVGVAAP 92
            |:|| |.||||||||:||||:||.|:|||:|||||||||||||||||||:||||.|  ..|...|
Zfish     9 KRGK-GSQMKSPEKKKRKSNSQGAAFSHLSEFAPPPTPMVDHLVASNPFDDDFGPPSRSAGGGGP 72

Human    93 ---PFLGSPVPFGG-----FRVQGGMAGQVPPGYSTGGGGGP---QPLRRQP--PP--------- 135
               .||.||...||     .|:.|||      |: .||.|||   ||.||.|  ||
Zfish    73 GGATFLPSPGAGGGGYGGPGRMGGGM------GF-MGGPGGPGSGQPGRRPPFGPPTPNTGPHHP 130

Human   136 ----------------------FPPNPMGPA-FNMPPQ-------------------------GP 152
                                  |||.  ||: |||||.                         |.
Zfish   131 LGFGGMPGFGGGGGGGGGGGGGFPPG--GPSQFNMPPNFSPPMHPGQGFNPMLSPGAMGGGPGGG 193

Human   153 GYPPPGNMNFPSQ---------PFNQP-----LGQNFSPPSGQMMP-------------GPVGGF 190
            |.||......|.|         |||.|     .|.. .||.|.|.|             |..||.
Zfish   194 GGPPHPRFGMPQQQPPHGQGGHPFNSPPLPGGPGPR-GPPHGPMNPMGGMGGGMNMMGMGGGGGG 257

Human   191 GPMISPTMGQPPRAELGPP-------------SLSQRFAQP-GAPFGPSPLQRPGQGLPSLPP-- 239
            |.|:....|.||:.:..||             ...:.|..| |.|..||..|.|... ||.||
Zfish   258 GNMVGGHPGMPPQGQFPPPQDGPYPGSSPPVGEEGKNFGGPGGGPPVPSQQQPPNLN-PSGPPSN 321

Human   240 NTSPFPGPDPGFPGPGG---EDGGKPLNP-----PASTAFPQEPHSGSPAAAVNGNQPSF----- 291
            |.:|.|.|.||.|.|||   :|..:| ||     |.|...|..|:| ||...:||.||..
Zfish   322 NATPGPSPAPGHPQPGGGFPQDVPQP-NPNTPGQPQSVPQPPNPNS-SPTGPLNGPQPQAPNNQH 384

Human   292 -PPNSSGRGG------------------------------------------------------- 300
             ||||:|..|
Zfish   385 PPPNSTGGPGPNTPSNQQQPTPPNSAPGSTPYSQQNNTPGGPMPNQPPNSNQNNLNNNSSGSNTP 449

Human   301 -----------GTPDANSLAPPGKAGGGSGP-QPPP----GLVYPCGACRSEVNDDQDAILCEAS 349
                       .||:..|..|.|.|...||| ..||    |:|:|||.|.|||:|||:|||||||
Zfish   450 GSNPNPPSNSNSTPNTQSPLPSGPAPPSSGPGSGPPKLGGGMVFPCGLCMSEVHDDQEAILCEAS 514

Human   350 CQKWFHRECTGMTESAYGLLTTEASAVWACDLCLKTKEIQSVYIREGMGQLVAANDG 406
            ||:||||:|||:||.||||||.|::||||||.||||||||:||:|:|:|||||||||
Zfish   515 CQRWFHRDCTGLTEPAYGLLTRESAAVWACDFCLKTKEIQAVYVRQGLGQLVAANDG 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PYGO2	NP_612157.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		34/42 (81%)
		Nuclear localization signal. /evidence=ECO:0000255	41..47		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..323		104/402 (26%)
		PHD_PYGO2	329..382	CDD:277106	41/52 (79%)
pygo2	NP_001028283.2	PRK14959	<316..>426	CDD:184923	34/111 (31%)
		PHD_PYGO2	494..547	CDD:277106	41/52 (79%)