DRSC/TRiP Functional Genomics Resources

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Protein Alignment PYGO2 and lgs

DIOPT Version :10

Sequence 1:NP_612157.1 Gene:PYGO2 / 90780 HGNCID:30257 Length:406 Species:Homo sapiens
Sequence 2:NP_651922.1 Gene:lgs / 43791 FlyBaseID:FBgn0039907 Length:1469 Species:Drosophila melanogaster


Alignment Length:494 Identity:119/494 - (24%)
Similarity:160/494 - (32%) Gaps:156/494 - (31%)


- Green bases have known domain annotations that are detailed below.


Human     2 AASAPPPPDKLEGGGGPAPPPAPPSTGR----KQGKAGLQMKSPEKKRRKSNTQGPAYSHLTEFA 62
            |||:|        |..|.|.....|...    |.|...:||:      |:::.||.:    .:|:
  Fly   926 AASSP--------GFNPHPHMQSNSNSALNAYKMGSTNIQME------RQASAQGGS----VQFS 972

Human    63 ---------------PPPTPMVDHLVASNPFEDDFGAPKVGVAAPPFLGSPVPFGGFRVQGGMAG 112
                           |||..|..:.   :|........:...:....:|||...||..:.||...
  Fly   973 RRSDNIPLNPNSGNRPPPNKMTQNF---DPISSLAQMSQQLTSCVSSMGSPAGTGGMTMMGGPGP 1034

Human   113 ---QVPPGYSTG-GGGGPQPLRR---QPPPFPPNPMGPAFNMPPQ----GPGYPPPGNMNFPSQP 166
               .:..|..:| .|.|...:.:   .......|.|||....|..    ||..||..|.|.|:..
  Fly  1035 SDINIEHGIISGLDGSGIDTINQNNCHSMNVVMNSMGPRMLNPKMCVAGGPNGPPGFNPNSPNGG 1099

Human   167 FNQ-PLG--------QNFS---PPSGQMMPGPVGGFGPMISPTMG-----------QPPRAELG- 207
            ..: .:|        .||.   ||..:||......||...:|.:.           .|.||:.. 
  Fly  1100 LRENSIGSGCGSANSSNFQGVVPPGARMMGRMPVNFGSNFNPNIQVKASTPNTIQYMPVRAQNAN 1164

Human   208 ------------PPSLS--QRFAQP--GAPFGPSPLQRPGQGLPSLPPNTSPFPGPDPGFP---- 252
                        ||||.  ||:|.|  ||         .|.|.|..||:.|   ...||.|    
  Fly  1165 NNNNNGANNVRMPPSLEFLQRYANPQMGA---------VGNGSPICPPSAS---DGTPGMPGLMA 1217

Human   253 GPGGEDGGKPLNPPASTAFPQEPHSGSPAAAVNG-------NQPSFPPNSSGRGGGTPDANSLAP 310
            |||.  ||..:|  :|....|...:.:|.|: ||       ||.|......|.            
  Fly  1218 GPGA--GGMLMN--SSGEQHQNKITNNPGAS-NGINFFQNCNQMSIVDEEGGL------------ 1265

Human   311 PGKAGGGSGPQPP------PGLVYP--CGACRSEVN------DDQDAILCEASCQKWF-HRECTG 360
            ||..|..:..||.      |..:.|  .||....||      ...|.|.|......:| :..|..
  Fly  1266 PGHDGSMNIGQPSMIRGMRPHAMRPNVMGARMPPVNRQIQFAQSSDGIDCVGDPSSFFTNASCNS 1330

Human   361 MTESAYGLLTTEASAVWACDLCLKTKEIQSVYIREGMGQ 399
            .....:|      ||..|..  .||:.|::  |..||.|
  Fly  1331 AGPHMFG------SAQQANQ--PKTQHIKN--IPSGMCQ 1359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PYGO2NP_612157.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73 20/89 (22%)
Nuclear localization signal. /evidence=ECO:0000255 41..47 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 106..323 70/278 (25%)
PHD_PYGO2 329..382 CDD:277106 14/61 (23%)
lgsNP_651922.1 BCL9 521..557 CDD:431912
ROM1 764..>995 CDD:227709 20/86 (23%)
Blue background indicates that the domain is not in the aligned region.

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