Protein Alignment PYGO2 and pygo

DIOPT Version :10

• Sequence 1: NP_612157.1
• Gene: PYGO2 / 90780
• HGNCID: 30257
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_651872.1
• Gene: pygo / 43718
• FlyBaseID: FBgn0043900
• Length: 815
• Species: Drosophila melanogaster
• Alignment Length: 701
• Identity: 170/701 - (24%)
• Similarity: 199/701 - (28%)
• Gaps: 352/701 - (50%)

Human    10 DKLEGGGGPAPPP------APPSTGRKQGKAGLQMKSPEKKRRKSNTQGPAYSHLTEFAPPP--- 65
            |::..||||.|||      .|...|...|                :..|| :.|:.  .|||
  Fly   144 DRMGMGGGPPPPPHMHPHMHPHHPGGPMG----------------HPHGP-HPHMG--GPPPMRG 189

Human    66 -TPMVDHLVASNPFEDDFGAPKVGVAAPPFL-----------GSPVP----------FGGFRVQG 108
             :||..|.:...|          ||..||.:           |.|||          .||....|
  Fly   190 MSPMHPHQMGPGP----------GVGLPPHMNHGRPGGPGGPGGPVPMGSPMGGIAGMGGMSPMG 244

Human   109 GMAG-QVPP------GYSTGGGG--GPQPLRRQPPPF-------PPN--PMG-PAFNM------P 148
            ||.| .:.|      |.|..|||  ||.|...|..|.       |.|  ||| |..|.      |
  Fly   245 GMGGPSISPHHMGMGGLSPMGGGPNGPNPRAMQGSPMGGPGQNSPMNSLPMGSPMGNPIGSPLGP 309

Human   149 PQGPGYPPPGNMNFPSQPFNQP------LGQNFSPP-----------SGQMMP-GPVGGFGP--- 192
            |.|||...|||...|.|...||      .||...||           .|..|| ||:.|.||
  Fly   310 PSGPGPGNPGNTGGPQQQQQQPPQPPMNNGQMGPPPLHSPLGNGPTGHGSHMPGGPIPGPGPGPG 374

Human   193 ------MISPTMG---------------------------------------QPPRAELG----- 207
                  .|||..|                                       .|....||
  Fly   375 GLVGPGGISPAHGNNPGGSGNNMLGGNPGGGNSNNNGSNTSNASNNNQNPHLSPAAGRLGVPTSM 439

Human   208 ------------------------------------------PPSLSQRFA------QPGAP-FG 223
                                                      ||::|...:      .||.| .|
  Fly   440 QSNGPSVSSVASSSVPSPATPTLTPTSTATSMSTSVPTSSPAPPAMSPHHSLNSAGPSPGMPNSG 504

Human   224 PSPLQRP-------------------GQGLPSL------------PPNTSPFP------------ 245
            |||||.|                   ||.:|:.            ||...|.|
  Fly   505 PSPLQSPAGPNGPNNNNSNNNNGPMMGQMIPNAVPMQHQQHMGGGPPGHGPGPMPGMGMNQMLPP 569

Human   246 -------------------------GPDPGFPGPGGEDGGKPLNPPASTAFPQE----------- 274
                                     ||.|...|..|..||....||.....|..
  Fly   570 QQPSHLGPPHPNMMNHPHHPHHHPGGPPPHMMGGPGMHGGPAGMPPHMGGGPNPHMMGGPHGNAG 634

Human   275 PHSG--------SPAAAVNG-NQPSFP--------------------PNSSGRGGGTPDANSLAP 310
            ||.|        .|.....| |.|..|                    ||..|.|||.|    :.|
  Fly   635 PHMGHGHMGGVPGPGPGPGGMNGPPHPHMSPHHGHPHHHHNPMGGPGPNMFGGGGGGP----MGP 695

Human   311 PGKAGG-------------GSGPQP---------PPGL-------------VYPCGACRSEVNDD 340
            .|..|.             |.||:|         |||.             :||||.|..||||:
  Fly   696 GGPMGNMGPMGGGPMGGPMGVGPKPMTMGGGKMYPPGQPMVFNPQNPNAPPIYPCGMCHKEVNDN 760

Human   341 QDAILCEASCQKWFHRECTGMTESAYGLLTTEASAVWACDLCLKTKEIQSV 391
            .:|:.||:.|..:|||.|.|:||:|:.:|..|..|.|.||.|:.:|.|..|
  Fly   761 DEAVFCESGCNFFFHRTCVGLTEAAFQMLNKEVFAEWCCDKCVSSKHIPMV 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PYGO2	NP_612157.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		20/72 (28%)
		Nuclear localization signal. /evidence=ECO:0000255	41..47		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..323		105/491 (21%)
		PHD_PYGO2	329..382	CDD:277106	26/52 (50%)
pygo	NP_651872.1	PHD_dPYGO	749..802	CDD:277107	26/52 (50%)