DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ANGPTL1 and CG31832

DIOPT Version :9

Sequence 1:	NP_001363692.1	Gene:	ANGPTL1 / 9068	HGNCID:	489	Length:	491	Species:	Homo sapiens
Sequence 2:	NP_723894.2	Gene:	CG31832 / 318970	FlyBaseID:	FBgn0051832	Length:	227	Species:	Drosophila melanogaster

Alignment Length:	234	Identity:	84/234 - (35%)
Similarity:	133/234 - (56%)	Gaps:	34/234 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   257 TSPTKSPFKIPPVTFINEGPFKDCQQAKEAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVI 321
            |.|:.||..|..:....|.||:..|                           |:.:  ...|.||
  Fly    24 TCPSGSPNGIHQLMLPEEEPFQVTQ---------------------------CKTT--ARDWIVI 59

Human   322 QKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSSF 386
            |:|.||||||.::|.:||.|||:.:||:::||:.:|:::.:..::|.|:|:......|||.:..|
  Fly    60 QRRLDGSVNFNQSWFSYKDGFGDPNGEFFIGLQKLYLMTREQPHELFIQLKHGPGATVYAHFDDF 124

Human   387 RLEPESEFYRL-RLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNL 450
            :::.|:|.|:| |:|.|.|.||||:.:|..|:|:|.|||.|..:.|||..|.||||:::|..|:|
  Fly   125 QVDSETELYKLERVGKYSGTAGDSLRYHINKRFSTFDRDNDESSKNCAAEHGGGWWFHSCLSSSL 189

Human   451 NGVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMIKP 489
            ||:::|.|  .:...:||.|..::  ..||..||:||:|
  Fly   190 NGLYFREG--ETGMLNGIHWGRWK--FQSLTFVQIMIRP 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANGPTL1	NP_001363692.1	PB1	74..138	CDD:383100
ANGPTL1	NP_001363692.1	FReD	275..490	CDD:238040	78/216 (36%)
CG31832	NP_723894.2	FReD	28..225	CDD:238040	82/230 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810