DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SH2D2A and si:ch73-109i22.2

DIOPT Version :9

Sequence 1:	XP_016858251.1	Gene:	SH2D2A / 9047	HGNCID:	10821	Length:	405	Species:	Homo sapiens
Sequence 2:	XP_698916.2	Gene:	si:ch73-109i22.2 / 570350	ZFINID:	ZDB-GENE-141211-57	Length:	524	Species:	Danio rerio

Alignment Length:	385	Identity:	113/385 - (29%)
Similarity:	156/385 - (40%)	Gaps:	102/385 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    76 LQAETRAWFQKTQAHWLLQHG-AAPAWFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLVRFSE 139
            |:|.|..||::||...|...| ..|.|.|||.||          ||||:||:.||.||:|:|.||
Zfish   102 LRANTLLWFERTQLPRLQTPGQPLPCWLHGFATR----------REAEQLLQDKPLGCFLLRLSE 156

Human   140 SAVTFVLTYRSRTCCRHFLLAQLRDGR----HVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTE 200
            |.:.|||:||....||||::.:...|.    :::.||.|.|..|::|:.:||.:|:.|:.|.||.
Zfish   157 SKIGFVLSYRGEDRCRHFIIEEEESGAFGSVYLIAGESSHHKSLENLISYYTQNPVGPFNELLTV 221

Human   201 PLARQTPEPAGLS----LRTEESNFGSKSQDPNPQYS-------PIIKQGQAPVPMQKEGA-GEK 253
            |.   |....|:.    ||.:|:....|:.|...:..       .::.|.....|.|...| ||.
Zfish   222 PC---TQPYVGIEEIERLRNKETEVNGKATDQEEKTKLPLAIGPAVLNQLPTNPPNQITSATGET 283

Human   254 EPSQLLRPKPPIPAKPQLP-PEVYTI-----PVPRHRPA-PRPKPSNPIY-----NEPDEPIAFY 306
            .....:|.    |.|..|. ||...:     ||..:..| |..:||||..     :..|.|   |
Zfish   284 VQYAAIRK----PLKKTLSLPECKCVAETAPPVLENGTAEPAERPSNPNLTGDQAHTVDAP---Y 341

Human   307 AMGRGSP---GEAPSNIYVEVEDEGLPATLGHPVL--------RKSW---------------SRP 345
            |..:..|   .|..|||..:.:.:|..|....|.:        .|.|               |||
Zfish   342 ARVKKLPKAVSENTSNISTDPDLQGATAAFTPPSIPNFDSTADPKYWQLEPLHTYEETPFTHSRP 406

Human   346 ------VPGGQ-------------------NTGGSQLHSENSVIGQGPPLPHQPPPAWRH 380
                  ..|.:                   |..|:|  ..|:|...||.||.:|||...|
Zfish   407 EDIDCYAVGWRRQANEDAVNLLKNHEYSEVNIKGAQ--EGNAVPRPGPSLPLRPPPRSTH 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH2D2A	XP_016858251.1	None
si:ch73-109i22.2	XP_698916.2	SH2	121..223	CDD:301589	46/111 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CSZP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I12053
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205439at7742
OrthoFinder	1	1.000	-	-		FOG0011989
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14388
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7981
SonicParanoid	1	1.000	-	-		X9833
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.000