DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SH2D2A and Pi3K21B

DIOPT Version :9

Sequence 1:	XP_016858251.1	Gene:	SH2D2A / 9047	HGNCID:	10821	Length:	405	Species:	Homo sapiens
Sequence 2:	NP_001259817.1	Gene:	Pi3K21B / 33203	FlyBaseID:	FBgn0020622	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	214	Identity:	44/214 - (20%)
Similarity:	71/214 - (33%)	Gaps:	72/214 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    74 LFLQAETRAWFQ----------KTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLEPK 128
            :.||.....|.|          ..:|.|||:                    ....|.||.:|:..
  Fly   300 MILQMGFDKWQQLYETVSNQPHSNEALWLLK--------------------DAKRRNAEEMLKGA 344

Human   129 PQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSP 193
            |.|.:|:| :..|..:.|:...:...:|.|:.:...| .......:.:|.|:.|:.||..:.|..
  Fly   345 PSGTFLIR-ARDAGHYALSIACKNIVQHCLIYETSTG-FGFAAPYNIYATLKSLVEHYANNSLEE 407

Human   194 YGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAP-----VPMQKEGAGEK 253
            :.:|||..|.                             .|::.....|     :.:|:|...|.
  Fly   408 HNDTLTTTLR-----------------------------WPVLYWKNNPLQVQMIQLQEEMDLEY 443

Human   254 EPSQLLRPKP------PIP 266
            |.:..|||.|      |||
  Fly   444 EQAATLRPPPMMGSSAPIP 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH2D2A	XP_016858251.1	None
Pi3K21B	NP_001259817.1	SH2_nSH2_p85_like	14..123	CDD:198195
		PI3K_P85_iSH2	129..302	CDD:293063	0/1 (0%)
		iSH2_PI3K_IA_R	138..303	CDD:304922	0/2 (0%)
		SH2_cSH2_p85_like	320..422	CDD:198184	28/152 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910