Protein Alignment TAAR5 and Octbeta2R

DIOPT Version :10

• Sequence 1: NP_003958.2
• Gene: TAAR5 / 9038
• HGNCID: 30236
• Length: 337
• Species: Homo sapiens
• Sequence 2: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 335
• Identity: 105/335 - (31%)
• Similarity: 165/335 - (49%)
• Gaps: 55/335 - (16%)

Human    36 VIYLACAAGMLIIVL----GNVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSV 96
            ::::..|..||:|::    ||:.|..:|...:.|...||:.::|||:||:.:.::.:..:....|
  Fly   151 IVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQV 215

Human    97 ESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGV 161
            ...|.|..|||.|...||..|...||.|||.||:||:.||..||.||...|.||....:|..|..
  Fly   216 TGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWIS 280

Human   162 PA--AYTSLFL--YTDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPL-FFVPCLIMISLYVK 221
            ||  ::..:|:  ||   ..:..|::.:.|.  .|..::||::..::..: |::||.|||..|:.
  Fly   281 PALLSFLPIFIGWYT---TPQHQQFVIQNPT--QCSFVVNKYYAVISSSISFWIPCTIMIFTYLA 340

Human   222 IFVVATRQAQQI---------------TTLSKSLAGAA-------------------------KH 246
            ||..|.||.:|:               ....::|:|:.                         |.
  Fly   341 IFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKR 405

Human   247 ERKAAKTLGIAVGIYLLCWLPFTI-DTMVDSLLHFITPPLVFDIFIWFAYFNSACNPIIYVFSYQ 310
            |.|||:||||.:|.::||||||.: .|:..:......|.:|..|..|..||||..||:||.:..:
  Fly   406 EHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNR 470

Human   311 WFRKALKLTL 320
            .||:|.:.||
  Fly   471 DFREAFRNTL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TAAR5	NP_003958.2	7tmA_TAAR5	35..316	CDD:320441	102/329 (31%)
		TM helix 1	36..62	CDD:320441	8/29 (28%)
		TM helix 2	69..95	CDD:320441	7/25 (28%)
		TM helix 3	107..137	CDD:320441	15/29 (52%)
		TM helix 4	149..172	CDD:320441	7/26 (27%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	176..189		2/12 (17%)
		TM helix 5	196..225	CDD:320441	11/29 (38%)
		TM helix 6	245..275	CDD:320441	17/30 (57%)
		TM helix 7	284..309	CDD:320441	11/24 (46%)
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	102/325 (31%)
		TM helix 1	155..181	CDD:320194	8/25 (32%)
		TM helix 2	188..214	CDD:320194	7/25 (28%)
		TM helix 3	226..256	CDD:320194	15/29 (52%)
		TM helix 4	268..291	CDD:320194	6/22 (27%)
		TM helix 5	315..344	CDD:320194	11/28 (39%)
		TM helix 6	404..434	CDD:320194	17/29 (59%)
		TM helix 7	444..469	CDD:320194	11/24 (46%)