DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF468 and LOC691254

DIOPT Version :9

Sequence 1:XP_016882932.1 Gene:ZNF468 / 90333 HGNCID:33105 Length:541 Species:Homo sapiens
Sequence 2:XP_006239419.1 Gene:LOC691254 / 691254 RGDID:1586256 Length:516 Species:Rattus norvegicus


Alignment Length:535 Identity:222/535 - (41%)
Similarity:283/535 - (52%) Gaps:82/535 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    21 NMHEGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCML--KTLSSTGQG 83
            |..:|.|||:|||.||:.|||:.|..|||.||.||:||.|.||:||:....|..  |.|..    
  Rat    46 NTLQGFLTFKDVAPEFTLEEWESLSFAQRALYMDVILETYYNLLSLENYVICEKHGKVLDR---- 106

Human    84 NTEVIHTGTLHRQASHHIG---EFCFHEIEKDIHGFEFQWKEDETNGHAAPMTEIKELAGSTGQH 145
            :||.:        ...|:.   :||             :|:            ||.::.      
  Rat   107 DTECV--------VDEHVNIQEKFC-------------KWE------------EISKVT------ 132

Human   146 DQRHAGNKRIKDQLGSSFHLHLPEPHIFQSEGKIGNQVE--------KSINNASSVSTSQRICCR 202
                     ::....:.:..:|.:|.:     |.|...|        :..|..:....:.||   
  Rat   133 ---------LESTQSTPYKTNLRDPTL-----KAGKTREVYKYKDCVQFSNECAIAGVNSRI--- 180

Human   203 PKTHISNKYGNNS-----LHSSLLTQKWEVHMREKSFECIQSFKSFNCSSLLKKHQIIHLEEKQC 262
               ||.||..|..     :|...||.|..:: .:...:|.:..|.|..:..|..||.||..:|:.
  Rat   181 ---HIENKEHNKEFDKDFVHEDKLTLKQNIN-GKNLHQCSECEKCFTKTRDLHLHQRIHTGKKRY 241

Human   263 KCDVCGKVFNQKRYLACHRRCHTGEKPYKCNECGKTFGHNSSLFIHKALHTGEKPYECEECDKVF 327
            ||..|.|.|.::.||..|:|.|||||||||:||.|.|....:|..|..:|||||||:|.||||.|
  Rat   242 KCSQCDKSFARESYLRHHQRIHTGEKPYKCSECDKCFTEKGTLRTHMRIHTGEKPYKCSECDKCF 306

Human   328 SRKSHLERHKRIHTGEKPYKCKVCDEAFAYNSYLAKHTILHTGEKPYTCNECGKVFNRLSTLARH 392
            :.|..|:||.|||||||||||..||:.|....:|..|..:|||||||.|:||.|.|........|
  Rat   307 TEKGTLKRHMRIHTGEKPYKCSECDKCFRLQFHLNIHQRIHTGEKPYKCSECEKYFTYKCNFRIH 371

Human   393 HRLHTGEKPYKCEECDKVFSRKSHLERHRRIHSGEKPYKCEECCKVFSRKSNLERHRRIHTGEKP 457
            .|:|||||||||.||||.|:.|..|..|:|||:|||||||.||.|.|..||:|..|:||||||||
  Rat   372 QRIHTGEKPYKCSECDKFFTEKGTLRFHQRIHTGEKPYKCGECDKCFGHKSHLSIHQRIHTGEKP 436

Human   458 YKCKVCDKAFQRDSHLAQHQRVHTGEKPYKCNECGKTFGQTSSLIIHRRLHTGEKPYKCNECGKT 522
            :||..|||.|.....|..|.|:|||||||||:||.|.|.......||:|:|||:|.||||||.|.
  Rat   437 FKCSQCDKCFTEKGTLRSHMRIHTGEKPYKCSECDKCFRLQCHRSIHQRVHTGDKRYKCNECDKC 501

Human   523 FSQMSSLVYHHRLHS 537
            |...|||..|.|:|:
  Rat   502 FGYKSSLRIHQRIHT 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF468XP_016882932.1 None
LOC691254XP_006239419.1 KRAB 52..91 CDD:279668 24/38 (63%)
COG5048 200..>495 CDD:227381 156/295 (53%)
C2H2 Zn finger 215..235 CDD:275368 6/19 (32%)
C2H2 Zn finger 243..263 CDD:275368 8/19 (42%)
zf-H2C2_2 255..279 CDD:290200 16/23 (70%)
C2H2 Zn finger 271..291 CDD:275368 7/19 (37%)
zf-H2C2_2 284..307 CDD:290200 14/22 (64%)
C2H2 Zn finger 299..319 CDD:275368 11/19 (58%)
zf-H2C2_2 312..334 CDD:290200 16/21 (76%)
C2H2 Zn finger 327..347 CDD:275368 6/19 (32%)
zf-H2C2_2 339..364 CDD:290200 14/24 (58%)
C2H2 Zn finger 355..375 CDD:275368 7/19 (37%)
zf-H2C2_2 367..391 CDD:290200 15/23 (65%)
C2H2 Zn finger 383..403 CDD:275368 10/19 (53%)
zf-H2C2_2 396..418 CDD:290200 15/21 (71%)
C2H2 Zn finger 411..431 CDD:275368 10/19 (53%)
zf-H2C2_2 423..447 CDD:290200 15/23 (65%)
C2H2 Zn finger 439..459 CDD:275368 8/19 (42%)
zf-H2C2_2 452..474 CDD:290200 15/21 (71%)
C2H2 Zn finger 467..487 CDD:275368 8/19 (42%)
C2H2 Zn finger 495..515 CDD:275368 11/19 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
HGNC 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100020
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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