Protein Alignment ZNF468 and Rex2

DIOPT Version :10

• Sequence 1: XP_047295570.1
• Gene: ZNF468 / 90333
• HGNCID: 33105
• Length: 541
• Species: Homo sapiens
• Sequence 2: XP_006239419.1
• Gene: Rex2 / 691254
• RGDID: 1586256
• Length: 516
• Species: Rattus norvegicus
• Alignment Length: 535
• Identity: 222/535 - (41%)
• Similarity: 283/535 - (52%)
• Gaps: 82/535 - (15%)

Human    21 NMHEGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCML--KTLSSTGQG 83
            |..:|.|||:|||.||:.|||:.|..|||.||.||:||.|.||:||:....|..  |.|..
  Rat    46 NTLQGFLTFKDVAPEFTLEEWESLSFAQRALYMDVILETYYNLLSLENYVICEKHGKVLDR---- 106

Human    84 NTEVIHTGTLHRQASHHIG---EFCFHEIEKDIHGFEFQWKEDETNGHAAPMTEIKELAGSTGQH 145
            :||.:        ...|:.   :||             :|:            ||.::.
  Rat   107 DTECV--------VDEHVNIQEKFC-------------KWE------------EISKVT------ 132

Human   146 DQRHAGNKRIKDQLGSSFHLHLPEPHIFQSEGKIGNQVE--------KSINNASSVSTSQRICCR 202
                     ::....:.:..:|.:|.:     |.|...|        :..|..:....:.||
  Rat   133 ---------LESTQSTPYKTNLRDPTL-----KAGKTREVYKYKDCVQFSNECAIAGVNSRI--- 180

Human   203 PKTHISNKYGNNS-----LHSSLLTQKWEVHMREKSFECIQSFKSFNCSSLLKKHQIIHLEEKQC 262
               ||.||..|..     :|...||.|..:: .:...:|.:..|.|..:..|..||.||..:|:.
  Rat   181 ---HIENKEHNKEFDKDFVHEDKLTLKQNIN-GKNLHQCSECEKCFTKTRDLHLHQRIHTGKKRY 241

Human   263 KCDVCGKVFNQKRYLACHRRCHTGEKPYKCNECGKTFGHNSSLFIHKALHTGEKPYECEECDKVF 327
            ||..|.|.|.::.||..|:|.|||||||||:||.|.|....:|..|..:|||||||:|.||||.|
  Rat   242 KCSQCDKSFARESYLRHHQRIHTGEKPYKCSECDKCFTEKGTLRTHMRIHTGEKPYKCSECDKCF 306

Human   328 SRKSHLERHKRIHTGEKPYKCKVCDEAFAYNSYLAKHTILHTGEKPYTCNECGKVFNRLSTLARH 392
            :.|..|:||.|||||||||||..||:.|....:|..|..:|||||||.|:||.|.|........|
  Rat   307 TEKGTLKRHMRIHTGEKPYKCSECDKCFRLQFHLNIHQRIHTGEKPYKCSECEKYFTYKCNFRIH 371

Human   393 HRLHTGEKPYKCEECDKVFSRKSHLERHRRIHSGEKPYKCEECCKVFSRKSNLERHRRIHTGEKP 457
            .|:|||||||||.||||.|:.|..|..|:|||:|||||||.||.|.|..||:|..|:||||||||
  Rat   372 QRIHTGEKPYKCSECDKFFTEKGTLRFHQRIHTGEKPYKCGECDKCFGHKSHLSIHQRIHTGEKP 436

Human   458 YKCKVCDKAFQRDSHLAQHQRVHTGEKPYKCNECGKTFGQTSSLIIHRRLHTGEKPYKCNECGKT 522
            :||..|||.|.....|..|.|:|||||||||:||.|.|.......||:|:|||:|.||||||.|.
  Rat   437 FKCSQCDKCFTEKGTLRSHMRIHTGEKPYKCSECDKCFRLQCHRSIHQRVHTGDKRYKCNECDKC 501

Human   523 FSQMSSLVYHHRLHS 537
            |...|||..|.|:|:
  Rat   502 FGYKSSLRIHQRIHT 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF468	XP_047295570.1	KRAB	26..67	CDD:460171	25/40 (63%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		C2H2 Zn finger	320..340	CDD:275368	11/19 (58%)
		COG5048	<324..497	CDD:227381	102/172 (59%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		C2H2 Zn finger	376..396	CDD:275368	7/19 (37%)
		C2H2 Zn finger	404..424	CDD:275368	10/19 (53%)
		C2H2 Zn finger	432..452	CDD:275368	10/19 (53%)
		C2H2 Zn finger	460..480	CDD:275368	8/19 (42%)
		C2H2 Zn finger	488..508	CDD:275368	8/19 (42%)
		zf-H2C2_2	500..525	CDD:463886	15/24 (63%)
		C2H2 Zn finger	516..536	CDD:275368	11/19 (58%)
Rex2	XP_006239419.1	KRAB	52..91	CDD:460171	24/38 (63%)
		COG5048	200..>495	CDD:227381	156/295 (53%)
		C2H2 Zn finger	215..235	CDD:275368	6/19 (32%)
		C2H2 Zn finger	243..263	CDD:275368	8/19 (42%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		C2H2 Zn finger	299..319	CDD:275368	11/19 (58%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		C2H2 Zn finger	383..403	CDD:275368	10/19 (53%)
		C2H2 Zn finger	411..431	CDD:275368	10/19 (53%)
		C2H2 Zn finger	439..459	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..487	CDD:275368	8/19 (42%)
		C2H2 Zn finger	495..515	CDD:275368	11/19 (58%)