Protein Alignment PKD2L1 and brv1

DIOPT Version :10

• Sequence 1: NP_057196.2
• Gene: PKD2L1 / 9033
• HGNCID: 9011
• Length: 805
• Species: Homo sapiens
• Sequence 2: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 743
• Identity: 162/743 - (21%)
• Similarity: 274/743 - (36%)
• Gaps: 159/743 - (21%)

Human    12 LQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPE--------DEPQETAYRTQVSS 68
            :..|.:..|  ||:..|.:|.....|.|......|:.:..:.|        :|.....||
  Fly    62 IMSLDAAFW--PAHQAPETPDENANVDTFMDNLRLRLRTLRSELMITERHRNERVNLKYR----- 119

Human    69 CCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVM 133
                           .:||      ||::  |.:..|||  |.:.:...      ....|:....
  Fly   120 ---------------LITE------ELWL--TGKLFLVY--FFMALAFF------DELLYFNTEA 153

Human   134 SELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYYE-NMLLGV 197
            :||.............::..:.|.:.|....|:  |.:|...|..    |...:|:.| ..||||
  Fly   154 TELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLV--LAFTDGKNTS----GGAPWIHAEGTRLLGV 212

Human   198 PRLRQLKVRND------SCVVHEDFREDILSCYDVYSPDKEEQLPFG--PFNGTAWTYHS----- 249
            .|||||:..::      ......||.|             ...||:.  |:....|..::
  Fly   213 VRLRQLRTESNRLGLSLPVFTERDFSE-------------SWTLPYERVPYTDKYWPIYTPWLPS 264

Human   250 -----QDELGGFSHWGRLTSY-SGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVY 308
                 .:.|.|.:|.|.:.:| ...||.:.|..:|..|.:.:..|.:..|||..|..:|:|||:|
  Fly   265 VSVARDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLY 329

Human   309 NANINLFCVLRLVVE-FPATGGAIPSWQIRT-----VKLIRYVSNWDFFIVGCEVIFCVFIFYYV 367
            ||:.|.|.|..|.|| ||.   ..|....|.     |:.:|     :|...|..::|...:.:..
  Fly   330 NADANTFTVCTLWVEKFPY---QYPDGHTRIESHTFVEQLR-----EFTKFGMLMVFVFVVTWLQ 386

Human   368 VEEILELHI-HRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEV-NRLMGKLLQQPNTYADFEF 430
            ..:...|.: :..|.|.::|..:|.:::.||:| ||.    .:.| :.|:.|:::........:|
  Fly   387 FTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLV-VGM----IMSVRDNLVQKMIKSVEIAVVVDF 446

Human   431 LAF---WQTQYNNMNAVNLFFAWI--KIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFA 490
            |.|   .|..|.......|..|.:  :::|.:.|:.|....:.|:|.....:|...|:..|...|
  Fly   447 LDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIA 511

Human   491 YAQLGYLLFGTQVENFSTFIKCIFTQFRIILG--------DFDYNAIDNANRILGPAYFVTYVFF 547
            .......:.|....||..|.|.|.|......|        |..|     ....||...:....|.
  Fly   512 IGIATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFY-----GGEWLGILLYTIMGFV 571

Human   548 VFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKER---VSDVQKVL 609
            |.::|:|:.::::.|..:.||            :|..|:...:......||.|.   ::.:.||.
  Fly   572 VKYMLINLIVSMMRDQMASVK------------ADRDKKVRQRITFWQFLRVEYAHFINYIVKVF 624

Human   610 --QGGEQEIQFEDFTNTLRELGHAE--HEITELTATFTK------FDRDGNRILDEKEQEKMRQD 664
              |.|.|........|..|:|...|  ...|::::.:::      .|:|       .||.|.|:.
  Fly   625 HCQKGYQRKNRTVAQNIQRKLNSNELKRRKTKISSIYSETIYVMPIDKD-------LEQMKYRER 682

Human   665 LEEE---RVALNTEIEKLGRSIVSSPQG 689
            :|..   ...|:|::|.:.|.:....:|
  Fly   683 IERTFTLAAILHTQMELMERLMFGDEEG 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD2L1	NP_057196.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		11/54 (20%)
		Polycystin_dom	147..342	CDD:466668	58/220 (26%)
		PKD_channel	343..567	CDD:462341	50/238 (21%)
		Fer4_24	702..735	CDD:436280
		Required for homooligomerization	704..763
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..805
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	57/217 (26%)
		PKD_channel	364..591	CDD:462341	50/241 (21%)