DRSC/TRiP Functional Genomics Resources

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Protein Alignment PKD2L1 and brv2

DIOPT Version :9

Sequence 1:NP_057196.2 Gene:PKD2L1 / 9033 HGNCID:9011 Length:805 Species:Homo sapiens
Sequence 2:NP_648970.2 Gene:brv2 / 39932 FlyBaseID:FBgn0036712 Length:736 Species:Drosophila melanogaster


Alignment Length:766 Identity:170/766 - (22%)
Similarity:282/766 - (36%) Gaps:204/766 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    12 LQKLGSGAW--DNPAY----SGPPSPH-GTLRVCTISSTGPLQPQPKKPEDEPQETAYRTQVSSC 69
            :|.:....|  ::|.|    .||...| |.|::                    :..:.|::    
  Fly    66 IQSIDYATWPQEDPPYRAEEGGPTMDHIGYLKI--------------------RLRSLRSE---- 106

Human    70 CLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMS 134
             |.|.:|           :|.|......|....:||:|..:.:.:.|:.......:.||.|..|.
  Fly   107 -LLISEG-----------HTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQ 159

Human   135 ELFLHTPSDT-GVS-----FQAISSMADFWDFAQGPLLDSLYWTK------WYNNQSLGHGSHSF 187
            .||....|.| |:|     :|..|.|       :..|:::.|..|      |:..:         
  Fly   160 RLFWDNTSVTFGLSQVYFIYQVHSYM-------KITLVEAFYAQKTNGYEGWWAME--------- 208

Human   188 IYYENMLLGVPRLRQLKVRNDSCVV--------------------HE-DFREDILSCYDVYSPDK 231
               :...:||.||||:  |...|.:                    |. .:.|.....||.:.|.:
  Fly   209 ---QWQKIGVVRLRQM--RPVDCHIGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAE 268

Human   232 EEQLPFGP--FNGTAWTYHSQDELGGFSHWGRLTSY-SGGGYYLDLPGSRQGSAEALRALQEGLW 293
                 |.|  .||....|         .|:|.|.:| ...||.:.:..::....:.:..|::..|
  Fly   269 -----FEPSFLNGLLLNY---------DHYGYLLNYPEVAGYVVLMMSTKINCLKQIEYLRDYSW 319

Human   294 LDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYV---SNWDFFIVGC 355
            ||:.|..:|||.::|||:.|||.::.|.||....|..:|...:.:|.::..|   ||.:..|   
  Fly   320 LDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHVDSVSMLGNVETRSNSELLI--- 381

Human   356 EVIFCVFIFYYVVEEILELH------IHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
                   :|.|.|..||...      .|........|.::||.:.:|::......|.|.:|.:  
  Fly   382 -------LFVYTVLVILFARGVFTKIWHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDIETD-- 437

Human   415 MGKLLQQPNTYADFEFLAFWQ--TQYNNMNAVNLFFAWI---KIFKYISFNKTMTQLSSTLARCA 474
              .|||...|....::|.|.:  ..:..:..|..|...|   :::|.:.|.......:.||....
  Fly   438 --ALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAW 500

Human   475 KDILGFAVMFFIVFFAYAQLGYLLF---GTQVENFSTFIKCIFTQFRIILG-DFDYNAID--NAN 533
            :.:....|:..:|..|   :|..|.   |.....||..::.:.|.....:| :.|.:..|  :..
  Fly   501 RAVASLGVIILVVLMA---IGITLAVPNGNNAVVFSHMVQSVVTCMWYSMGFNGDIHPADFFHGG 562

Human   534 RILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLR-LRL 597
            ||||...::..||.:..:|:|:|.::|.|.::|.             |.:||:..|::.:. |..
  Fly   563 RILGILLYLALVFLLAIILMNVFASVIYDYFNET-------------SRILKEHSNRSSITFLEF 614

Human   598 RKERVSDVQKVLQGGEQEIQFEDFTNTLREL----GHAEHEITELTAT---FTKFDRDGNRILDE 655
            .....:|:            |.|....||:.    ||...|..||...   ..||.||    |.:
  Fly   615 LHVEYADL------------FGDAFRCLRKTYESRGHTVAENVELELNRRELIKFKRD----LIK 663

Human   656 KEQEKMRQDL-EEERVA---------------LNTEIEKLGRSIVSSPQGK 690
            ..||..|..| ||:|.|               ||.::|.|.|.::....||
  Fly   664 SPQELKRALLTEEQRSADYRLRGEKLFKLMAILNLQVEILERMVLGDKDGK 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKD2L1NP_057196.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 9/53 (17%)
PKD_channel 147..567 CDD:400395 105/474 (22%)
Fer4_24 702..735 CDD:407943
Required for homooligomerization 704..763
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..805
brv2NP_648970.2 PKD_channel 169..596 CDD:285288 107/478 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3599
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46093
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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