DRSC/TRiP Functional Genomics Resources

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Protein Alignment PKD2L1 and Pkd2

DIOPT Version :10

Sequence 1:NP_057196.2 Gene:PKD2L1 / 9033 HGNCID:9011 Length:805 Species:Homo sapiens
Sequence 2:NP_609561.2 Gene:Pkd2 / 34651 FlyBaseID:FBgn0041195 Length:924 Species:Drosophila melanogaster


Alignment Length:893 Identity:244/893 - (27%)
Similarity:381/893 - (42%) Gaps:239/893 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    12 LQKLGSGAWDNPAYSGPPS----PHGTLRVCTISSTGP--------------------------- 45
            |:..|....|.|:.|..||    |..:.|. |:...||                           
  Fly   100 LRDPGQSTSDKPSTSDKPSTSDKPSTSART-TVREPGPSSSPSRPVSTRESGRITFQEAAPSTSA 163

Human    46 -------LQPQPKKPEDEPQETAYRTQV----SSCCLHICQGIRG---LWGTTLTENTAENRELY 96
                   .:|:|.||.::...:.::.:.    ||......:|.|.   :..:.|......||.||
  Fly   164 KVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILY 228

Human    97 -----IKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLH-----TPSDTGVSFQAI 151
                 ::..|.|..|:|:||:...|:...:..:..:|:...|.:||.:     .||.| |.|:.:
  Fly   229 TTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVT-VGFEKL 292

Human   152 SSMADFWDF-------------------------------------------------------A 161
            .::.|:||:                                                       .
  Fly   293 ITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPE 357

Human   162 QGPLLDSLYWTKWYN--------------------------------------------NQSLGH 182
            :.|.:|.|.....||                                            |.|..|
  Fly   358 EAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHH 422

Human   183 GSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPF---GPFNGTA 244
            .......|||:|||.|||||::||.:||.|::.|.....:||..||...|::.|.   .||.   
  Fly   423 LEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPMHKGSPFR--- 484

Human   245 WTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYN 309
             |.|   :|.....|..|..|..|||.::|...:..:.:.:..|::..|||||:|:..::|:::|
  Fly   485 -TMH---DLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFN 545

Human   310 ANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILEL 374
            .|.::|..::|:.|.|.|||.||...::|||:..:.::....:....:.:.:.:.||.:.||.|:
  Fly   546 ENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEI 610

Human   375 HIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQY 438
            ....:: |..|:.||||..::|...:|:.::|:.:.:|..|..: .....||...:.|.||...|
  Fly   611 RKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTAR-AHSDVTYQSLDVLCFWNIIY 674

Human   439 NNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQV 503
            .:|.|:..|..||||||:||||||:.|.::||.||:||:.||::||.|||.||||||.|||||:.
  Fly   675 VDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKH 739

Human   504 ENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVK 568
            .:|..||..|.|..|:|||||.||.|:.|||:|||.||:||:..|||:|||||||||.:||:.||
  Fly   740 PDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVK 804

Human   569 EELAGQKDEL------QLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLRE 627
            .|:...:..|      :||.:|   |..|....:.|..            .|..:.|| .:...:
  Fly   805 GEITQGRSHLGSYIYRKLSGML---YWITHCGRKRRHH------------PQASETED-KDAEHD 853

Human   628 LGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEKLGRSIVSSPQGKSG 692
            :|.|..|..|:....|           ..||:..: |:                     |||:: 
  Fly   854 VGAAHDETHEIRKNMT-----------PAEQQYFK-DI---------------------PQGEN- 884

Human   693 PEAARAGGWVSGEEFYMLTRRVLQLETVLEGVVSQIDAVGSKLKMLER 740
                        ::...|..||..||.:||.:::.:|.:   ||.:|:
  Fly   885 ------------QDMVRLNNRVGLLEEILEKLINNMDDI---LKRVEK 917

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKD2L1NP_057196.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 16/84 (19%)
Polycystin_dom 147..342 CDD:466668 69/296 (23%)
PKD_channel 343..567 CDD:462341 100/224 (45%)
Fer4_24 702..735 CDD:436280 8/32 (25%)
Required for homooligomerization 704..763 11/37 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..805
Pkd2NP_609561.2 DUF5585 <29..272 CDD:465521 34/172 (20%)
Polycystin_dom 404..578 CDD:466668 60/180 (33%)
PKD_channel 579..803 CDD:462341 100/224 (45%)
Blue background indicates that the domain is not in the aligned region.

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