Protein Alignment PKD2L1 and brv3

DIOPT Version :10

• Sequence 1: NP_057196.2
• Gene: PKD2L1 / 9033
• HGNCID: 9011
• Length: 805
• Species: Homo sapiens
• Sequence 2: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Alignment Length: 740
• Identity: 162/740 - (21%)
• Similarity: 300/740 - (40%)
• Gaps: 163/740 - (22%)

Human    98 KTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSD-TGVSFQAISSMADFWDFA 161
            |....:|.:|..:.:.:..|.......:.|:.|:::::||::..:| ||:  |.:..:...:||.
  Fly   123 KMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGL--QEVYFLNQLFDFI 185

Human   162 QGPLLDSLYWTKWYNNQSLGHGSHSFIYYE-NMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYD 225
            :..|:.:      :|:.|...||..:.:.| ::||||.|||||:|.|....:......|     .
  Fly   186 ESTLVLA------FNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSD-----T 239

Human   226 VYSPDKEEQLPFGP--FNGTAWTYHS------------QDELGGFSHWGRLTSYSG-GGYYLDLP 275
            .|.||  .|||:..  ::...|..:.            ...|..|.|.|.|.||.. .||...|.
  Fly   240 YYMPD--WQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLA 302

Human   276 GSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVK 340
            .|...|.:.:..|.|..||...|..|||||::||.::|||.:..|.||....||.:|..|:.:.|
  Fly   303 RSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAK 367

Human   341 LIRYVSNWDFF-IVGCEVIFCVFIFY---YVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAV 401
            |:..|....:. ::...:...|||.:   ..|:...|.|:     |.|:||.|||.:.:::::.|
  Fly   368 LLENVDQMPYTGLLALLIYVLVFIQFAQTLAVKLWYEPHL-----LKSVWNKLDLFIFMVNVLVV 427

Human   402 GFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQ-TQYNNMNAVNLFF----AWIKIFKYISFNK 461
            ...:.|    ..|:..::::....:..||:.|.: ::.:.:..:.:.|    ..:::::.:.|..
  Fly   428 VLVVLR----ESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFAS 488

Human   462 TMTQLSST--LARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDF 524
            .....:.|  ||..|......|::.|::.|.:|.:  .:.|....||:..:|   :....:...|
  Fly   489 VFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVV--TINGNYSSNFNKLVK---SMVMCMCYSF 548

Human   525 DYNA------IDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDL 583
            .::|      :.:..:.||...:....|.:..:|:|:|:::|||.::
  Fly   549 GFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFT------------------ 595

Human   584 LKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRD 648
                                 |.|.::..|:|.:...|...:.|.........:|......:.|:
  Fly   596 ---------------------VAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRN 639

Human   649 G-------NRILDEKEQEK-MRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGE 705
            |       :|.||..:::: ||:.|.:            ||..||.|              ||.|
  Fly   640 GRTVAENVSRKLDSMDRQRLMRRRLRQ------------GRHHVSRP--------------VSAE 678

Human   706 EFYMLTRRVLQLETVLEGVVSQIDAVGSKLKML------ERKGWLAPSPGVKEQAIWKHPQPAPA 764
            :      .:|:.:...:.:|:....:..:|.::      |...|      .:||.  |.|:   |
  Fly   679 D------ALLEYKDRGDKMVNVHYILNIQLTLIRMFLFDEYVEW------PQEQQ--KQPE---A 726

Human   765 VTPDP-WGVQGGQESEVPYKREEEA 788
            ..||| .|..|....:   ||::||
  Fly   727 QDPDPNLGPDGSPPQD---KRQDEA 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD2L1	NP_057196.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59
		Polycystin_dom	147..342	CDD:466668	63/210 (30%)
		PKD_channel	343..567	CDD:462341	45/240 (19%)
		Fer4_24	702..735	CDD:436280	5/32 (16%)
		Required for homooligomerization	704..763		10/64 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..805		11/31 (35%)
brv3	NP_001284831.1	Polycystin_dom	171..369	CDD:466668	64/212 (30%)
		PKD_channel	370..595	CDD:462341	45/238 (19%)