Protein Alignment RHBDL1 and stet

DIOPT Version :10

• Sequence 1: XP_016879338.1
• Gene: RHBDL1 / 9028
• HGNCID: 10007
• Length: 469
• Species: Homo sapiens
• Sequence 2: NP_788450.1
• Gene: stet / 38169
• FlyBaseID: FBgn0020248
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 347
• Identity: 111/347 - (31%)
• Similarity: 156/347 - (44%)
• Gaps: 73/347 - (21%)

Human    81 DPENTGFIGADTFTGLVHSHE----LPLDPAKLDMLVALAQSNE----QGQVCYQELVDLISSKR 137
            |||..|.|..:.|...:.|.|    :|::  |.::|:..|:..:    .|.|.:|:.|:::|.||
  Fly    98 DPEGFGEISVEEFLEALKSPEFLSQVPMN--KRELLLERAKKAKLPTGPGYVTFQDFVNVMSGKR 160

Human   138 SSSFKRAIANGQRALPRDGP----LDEPGLGVYKRFVRYVAYEILPCEVDRRWYFYRHRSCPPPV 198
            :.|||.|:.:..|.:..:..    |:||.|  :::.|..||.||||.|.||::|..|:..||||.
  Fly   161 TRSFKCAVHHRDREVCSENDFQLVLNEPPL--FRKMVHAVAMEILPEERDRKYYADRYTCCPPPF 223

Human   199 FMASVTLAQIIVFLCYGARLNKWVLQTYH-----------PEYMKSPLVYHPGHRARAWRFLTYM 252
            |:..|||.::..|:             ||           |....|..:|.|..|...||||.||
  Fly   224 FIILVTLVELGFFV-------------YHSVVTGEAAPRGPIPSDSMFIYRPDKRHEIWRFLFYM 275

Human   253 FMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLA-ELGWDEMSLQVAEDGAGLGV-- 314
            .:|.|...||||..:||:.|:|||||||..||:.:|.:|||| .||.......|...||..||
  Fly   276 VLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPDVFLVGASGGVYA 340

Human   315 -------------HELRGGPGRVAALLP----------AAARLGPTAQLHGAPGRRGGGGEHGPD 356
                         |::|.|..::..:|.          .|...|...||       |...|....
  Fly   341 LLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFAIYARYAGDELQL-------GSSSEFLAI 398

Human   357 HPAELRGAPAGPVRLVGGAAGL 378
            ..||..||.:....|.|..|||
  Fly   399 DQAETAGAVSYVAHLAGAIAGL 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHBDL1	XP_016879338.1	Rhomboid	239..>294	CDD:451297	29/54 (54%)
stet	NP_788450.1	EF-hand_7	87..157	CDD:463900	16/60 (27%)
		Rhomboid	262..428	CDD:426384	57/166 (34%)