Protein Alignment HIP1R and Hip1

DIOPT Version :10

• Sequence 1: NP_003950.1
• Gene: HIP1R / 9026
• HGNCID: 18415
• Length: 1068
• Species: Homo sapiens
• Sequence 2: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Alignment Length: 1157
• Identity: 339/1157 - (29%)
• Similarity: 546/1157 - (47%)
• Gaps: 211/1157 - (18%)

Human    22 AEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKF 86
            ||:|.:...  :|:|||:|..|||:|.||||.||:..|..|.|.|||......||..|...:|||
  Fly     5 AEKEFYHLN--VSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKF 67

Human    87 CHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFP 151
            .|:||||||:||.:.:...|.::..|.|:|.:||.|.|..|..:..|:|||.||::||.|:..||
  Fly    68 SHLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFP 132

Human   152 AGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPL 216
            ..|.::...|..|...|:|..|||.||:|||::..:.|..::|..:......|....|||||||:
  Fly   133 GTLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPI 197

Human   217 IQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPR 281
            :.:|||.:.||..:|:|:||||..:|.|.:.|||||||..|..|::|:.....:.|||.||.||.
  Fly   198 VCLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPE 262

Human   282 LPEGPPNFLRASALAEHIKPVVVIPEE---APEDEEPENLIEISTGPPAGEPVVVADLFDQTFGP 343
            ||:..|||...:....::.|||.:|:|   ..||....|..|:.....|.:.:.:.:
  Fly   263 LPDSSPNFKSQNDFTSYVPPVVHVPQEPDPVVEDLVDTNNHELEAFSQAQQQLSMLE-------- 319

Human   344 PNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408
               .:..:::..||.|..:::.::...:.::...:..:.:|:.....|..:|...|:......:.
  Fly   320 ---GIISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLVLAREMCATFRMQ 381

Human   409 NEQLRHELAQ----LRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469
            |:.|..:|.|    |:.|.           |.|.|...:..::||||..::::...|.:|||:.:
  Fly   382 NDDLEMQLNQNPILLQKAM-----------EEEEKHKLSSEKFNKLKTLYTKIRDEHIQLLREQS 435

Human   470 DTAKQLTVTQQ--------------------------------SQEEVARVKEQLAFQVEQVKRE 502
            |..|.|...:|                                .|:::...||::| .:|.||.|
  Fly   436 DCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIA-HLEAVKNE 499

Human   503 SE----------------------------LKLEE---------------------KSDQLEKLK 518
            .:                            ||:||                     |::.:||:.
  Fly   500 MKEKFDDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDIEKML 564

Human   519 RELEAKAGEL-----ARAQEALSHTEQSKSELSSRLDTLSAEKD--------ALSGAVRQREADL 570
            :..||:...|     .::.|:.||:|...::|...:|.|. :||        .||.|..|.....
  Fly   565 KAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLE-QKDKEFNEVKLQLSSAESQISLKA 628

Human   571 LAAQSLVRETEA----------ALSREQQRSSQEQ-GELQGRLAERESQEQGLRQRLLDEQFAVL 624
            |..|:.::..||          .|..|.:.:|:.| .:||..|...|..|..|:|  ..|....|
  Fly   629 LEIQNNLKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQLQLTLNNLEQNESALQQ--TQEIVNQL 691

Human   625 RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALV 689
            |...|.|....:|..|||         |..:..:::|.:.:|||::   .:....|.|::...||
  Fly   692 RQENASAGQRNEDLQSKL---------SLTEVKLTQATQQIDAVTS---SYQICSTDLSELRKLV 744

Human   690 AALTR---FSHLAA----------------DTII----NGGATSHLAPTDPAD----------RL 721
            ....:   .|.|:.                :||:    |..|.:::|.|:...          :|
  Fly   745 IKTVKEICNSKLSGSEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLGYVFIKL 809

Human   722 IDTCR---------ECGARALELMGQL--------------QDQQALRHMQASLVRTPLQGILQL 763
            .|.|.         |.|.........|              :.::..|....:.::|.|:.|.:|
  Fly   810 YDQCDVIYKTTTAIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQKTITDIQTKLRDIEKL 874

Human   764 GQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCT 828
            .:::| .|.: ::.:|..:::.|:....|||:||..:|.|::.:||...:...||||.:|:::||
  Fly   875 IEKIK-ASFE-QKIDLDKLLEIELREMDAAIDDAASKITDLLAKAREKDNQTNLEVNGKIVDACT 937

Human   829 DLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKV 893
            .||:.::.|:..|..||.|||.|.:|.|:..|||.:||:|::|||||||:|...|..|||||:|.
  Fly   938 TLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANYLVEAANKA 1002

Human   894 V-LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQ 957
            : ..:||..||||.:.||||.|.|:|.||||||.::|..|:.|.:.||:|.:....:||:.|...
  Fly  1003 IESESGKNFELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATGTLVATVKDCN 1067

Human   958 EQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
            .|:|.:..::.|.|:..::|..|||..|:|||:|:.|:.:|::|...||:||
  Fly  1068 SQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEHY 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIP1R	NP_003950.1	ANTH	30..299	CDD:400137	114/268 (43%)
		Smc	<354..>811	CDD:440809	124/621 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..443		3/18 (17%)
		HIP1_clath_bdg	461..559	CDD:465154	35/191 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..549		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	582..608		9/36 (25%)
		ILWEQ	814..1012	CDD:214607	88/197 (45%)
		Important for actin binding	867..924		32/57 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1016..1060
Hip1	NP_648597.2	ANTH	11..278	CDD:400137	114/268 (43%)
		Mplasa_alph_rch	<312..783	CDD:275316	96/508 (19%)
		EnvC	662..>909	CDD:443969	54/262 (21%)
		ILWEQ	924..1122	CDD:214607	88/196 (45%)