DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF8 and spat-3

DIOPT Version :9

Sequence 1:	NP_003949.1	Gene:	RNF8 / 9025	HGNCID:	10071	Length:	485	Species:	Homo sapiens
Sequence 2:	NP_001024904.2	Gene:	spat-3 / 259704	WormBaseID:	WBGene00020496	Length:	2476	Species:	Caenorhabditis elegans

Alignment Length:	407	Identity:	68/407 - (16%)
Similarity:	151/407 - (37%)	Gaps:	120/407 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    49 QLVSKICPL-------------MISRNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLR-VYS 99
            |||.:..|:             |:::.:..:..|| .|..:||         .|.::|.:. ||.
Worm  1906 QLVQRQVPVGHPGQVNVPMPAQMLNQGNPQMAVNP-AQAQMMD---------ERRKMEEVNAVYH 1960

Human   100 IHQ--GDYIQLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELA 162
            :.|  |.:     |..|:|..:.::...:.|                             |...|
Worm  1961 LMQSRGQF-----PPTNQELFQVQFAQAQAD-----------------------------LRSAA 1991

Human   163 GPGAEGP------SNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIY 221
            ...|:..      :|::::...|:.:.....:.|.:.:.|:..:..|..:..|.:......|...
Worm  1992 AQAAQAAQAQAQMTNMRAQAEAVARQQAMMKQEQARAQAAAKEAARLKAETEAAKAKVQAEAEAR 2056

Human   222 PGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVV 286
            ....:...|...| |:.:.|:|...|.         :...|.|.:.:|::.:::..|.|....:.
Worm  2057 RKAEQEMRVRQAQ-AAQTQAAQAQAQS---------QAHAQNQAQTQAIVEIQRMIQSGQPLSMQ 2111

Human   287 QMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH-------------------------LQG 326
            || |:||.: ||:..:.|||..:::|::....:.:|.                         :||
Worm  2112 QM-QQLQQM-SQVQMQHAQQVQQMQQMQMQQLQMQQFAARMQQGTPKPAVSQQAVQQGMPAGIQG 2174

Human   327 LEIAQGEKDLK----------------QQLAQALQEHWALMEELNRSK-KDFEAIIQAKNKELEQ 374
            :....|.:.|:                ||.:||.|:...:..:|.:.: ...:...|.:.::.:|
Worm  2175 MPTGMGMQQLQGLGMPGMQLPQQAGQSQQTSQAQQQQLFMQLQLQQQQLMQHQLQQQLQMQQHQQ 2239

Human   375 TKEEKEKMQAQKEEVLS 391
            .:::::::|.|:::.|:
Worm  2240 HQQQQQQIQMQQQQQLA 2256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF8	NP_003949.1	FHA	17..110	CDD:238017	16/76 (21%)
		Required for interaction with PIWIL1. /evidence=ECO:0000255\|HAMAP-Rule:MF_03067	68..72		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..220		5/38 (13%)
		Golgin_A5	264..>379	CDD:313078	28/156 (18%)
		PHA02929	<370..485	CDD:331986	4/22 (18%)
		RING-HC_RNF8	400..441	CDD:319449
		RING-HC finger (C3HC4-type)	403..440	CDD:319449
spat-3	NP_001024904.2	RING-HC_RNF138	158..203	CDD:319458
		MSCRAMM_SdrD	<290..583	CDD:380149
		GREB1	<1301..>1430	CDD:374106
		PAT1	<1724..>1845	CDD:370676
		DUF1720	2150..>2199	CDD:369766	4/48 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910