DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRSK2 and AMPKalpha

DIOPT Version :9

Sequence 1:	XP_016874022.1	Gene:	BRSK2 / 9024	HGNCID:	11405	Length:	880	Species:	Homo sapiens
Sequence 2:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	722	Identity:	210/722 - (29%)
Similarity:	317/722 - (43%)	Gaps:	222/722 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVL 79
            :|.|.|..|||.|..|.||:|.|.:|..|||:||:||:|: |..|:.|:.|||..|||..|||::
  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89

Human    80 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 144
            ||:.|......:::::|:|||||||||:||.|:|...:||:||:||||.:|:||.|.|.||||||
  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154

Human   145 ENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFAL 209
            ||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|.:.|:|||||||:||
  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219

Human   210 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGK 274
            |.|.|||||:::..|..|:|.|:|.:|.::.....:|:..|::||..:|..:|.|:||.|:
  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF---- 280

Human   275 NEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLG--CFR---DRNKLLQDLLS-EEENQEKMI 333
                 ::.:|..:    .||..:.|.:|:|: :::.  |.:   ...::...||| :..:|..:.
  Fly   281 -----QKDLPAYL----FPSSIEQDSNVIDT-YAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335

Human   334 YFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPAR 398
            |.|::|.| |:...      ..|:|:                        |:.:....|||.|
  Fly   336 YHLIIDNK-RFADD------AANQIN------------------------EINNFFVAGSPPP-- 367

Human   399 RAIEMAQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISGASSGLSTSPLSSPRPIRKLVLPPPPP 463
                                                                        |||||
  Fly   368 ------------------------------------------------------------PPPPP 372

Human   464 EPPFVARPLATSTEPEACGSASRPGHVLPLQAALRPDPKTQTLPCKAKLTDKPLQGTKSNPFPAS 528
            .|                  .|...|..||                |.:|   :.|..|.....:
  Fly   373 VP------------------QSSMDHQAPL----------------ATVT---VGGGTSASSGTA 400

Human   529 TPARPPATGLCPQLAPPLGPPALRVPPRPPPAGIEP--NTKSVPTIQVT-----PHPSPRGSPLP 586
            ||. ||..|         |.|:..:|.||.|..|.|  :.:...::|.:     |..:.||
  Fly   401 TPV-PPVAG---------GTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARG---- 451

Human   587 TPKGTPVHTPKESPAGTPNPTPPS--------SPSVGGVPW--------RARLNSIKNSFLGSPR 635
               |||:...|.. .|..:.:.|:        :.......|        |.|..::|..     :
  Fly   452 ---GTPIKRAKWH-LGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTG-----K 507

Human   636 FHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLS 700
            |.:..||:              .::..||:..:|.||..:|   |...|        |::...|:
  Fly   508 FSKMSLQL--------------YQVDAKSYLLDFKSLTNDE---VEQGD--------DVIMESLT 547

Human   701 IPSLSHS 707
            .|.||.|
  Fly   548 PPPLSVS 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRSK2	XP_016874022.1	None
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	128/254 (50%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	15/94 (16%)
		AMPKA_C	457..580	CDD:213378	24/129 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910