DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRSK2 and par-1

DIOPT Version :9

Sequence 1:	XP_016874022.1	Gene:	BRSK2 / 9024	HGNCID:	11405	Length:	880	Species:	Homo sapiens
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	962	Identity:	252/962 - (26%)
Similarity:	384/962 - (39%)	Gaps:	246/962 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    14 QYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 78
            :::|.|:|.||:|||....|||..|..|.::|||||:::.:|:...|.|:.||:.|:|:::||::
  Fly   248 EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNI 312

Human    79 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLK 143
            :||..|.|.:|.|||::|:.||||:|||||..||:..||||..||||:||:.:||...|.|||||
  Fly   313 VKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK 377

Human   144 PENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFA 208
            .||||||.:.||:|||||.::.....|.|:|.||||.||.||:.:|:||||.:.||||.||||:.
  Fly   378 AENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 442

Human   209 LLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGG 273
            |:.|:||||...||:|.|:|.||.:.:|.::..||::|||..:.::.|:|.:||.|....|...|
  Fly   443 LVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMG 507

Human   274 KNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLL 338
            ..|.|.:..|..|..:        .||..::::.::|..|..   ::..||:....:....:|||
  Fly   508 FEEDELKPYIEPKADL--------ADPKRIEALVAMGYNRSE---IEASLSQVRYDDVFATYLLL 561

Human   339 DRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEM 403
            .||...|..:                         |.|.....|:..:|..|.|:...:......
  Fly   562 GRKSTDPESD-------------------------GSRSGSSLSLRNISGNDAGANAGSASVQSP 601

Human   404 AQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISG-------ASSGLSTSPLSSPRPIRKLVLPPP 461
            ...|..:::.:.|          :|..| |:.||       |:...:|..:.:..|
  Fly   602 THRGVHRSISASS----------TKPSR-RASSGVGPTNAAATVAAATGAVGAVNP--------- 646

Human   462 PPEPPFVARPLATSTEPEACGSASRPGHVLPLQAALRPDPKTQTLPCKAKLTDKPLQGTKSNPFP 526
                         |....|.|||:.       :|::..:.|.|.....|.:.:...:....|..|
  Fly   647 -------------SNNYNAAGSAAD-------RASVGSNFKRQNTIDSATIKENTARLAAQNQRP 691

Human   527 ASTPARPPATGLCPQLAPPLGPPALRVPPRPPPAGIEPNTKSVPTIQVTPHPSPRGSPLPTPKGT 591
            ||...:...|          ....|..|.:|..|.....|....|:..|....||.|.....|.:
  Fly   692 ASATQKMLTT----------ADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTS 746

Human   592 PVHTPKESPAGT------------------PNPTPPSSPSVGGVPWRARLNSI------------ 626
            ........||.|                  |...|..|....| ..|||.|:.
  Fly   747 STEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSG-QTRARNNTALEYSGTSGASGD 810

Human   627 -----KNSFLG--SPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKD 684
                 :.||..  |.||.:|    ||..:.:     :.|.:.:.:|.....|....:||...|::
  Fly   811 SSHPGRMSFFSKLSSRFSKR----PTIADEA-----AKPRVLRFTWSMKTTSPLMPDQIMQKIRE 866

Human   685 KPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYK-------ATGGPAVFQKPVKFQVDITYTEG 742
                                   |:.|.:...|.:       ..|.|.. ...|::::::.
  Fly   867 -----------------------VLDQNNCDYEQRERFVLWCVHGDPNT-DSLVQWEIEVC---- 903

Human   743 GEAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQL-----LSTHDPPAAQHLS---------DTT 793
              ......:..|.|..:||.|..||.:...|...|     .:.::..||...|         .||
  Fly   904 --KLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTTT 966

Human   794 NCMEM---MTGRLS--------------------------------KCGSPLSNFFDVIKQL--- 820
            ||...   .|.|||                                |..|.||.|     |:
  Fly   967 NCRRPSNDSTSRLSELSLLCRSLTSQQGSQRRKKSRLSTGGSEDQKKSNSLLSAF-----QMYSP 1026

Human   821 FSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPTGKDTAKMGP 872
            ||.::|.|:::            .:.|.......||...:.|...|.:.:.|
  Fly  1027 FSSKENMQSSE------------EVEDLHVIDTQPGHSVDVPLFADFSPINP 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRSK2	XP_016874022.1	None
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	125/251 (50%)
		S_TKc	253..504	CDD:214567	125/250 (50%)
		UBA_MARK_Par1	525..563	CDD:270522	9/40 (23%)
		MARK1-3_C	839..936	CDD:213381	20/126 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920