Protein Alignment MAP3K14 and Map3k14

DIOPT Version :10

• Sequence 1: XP_047292953.1
• Gene: MAP3K14 / 9020
• HGNCID: 6853
• Length: 1016
• Species: Homo sapiens
• Sequence 2: NP_058592.1
• Gene: Map3k14 / 53859
• MGIID: 1858204
• Length: 942
• Species: Mus musculus
• Alignment Length: 1018
• Identity: 799/1018 - (78%)
• Similarity: 852/1018 - (83%)
• Gaps: 78/1018 - (7%)

Human     1 MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITKG 65
            |||||:||||.|||||||||||.||||||..||||||.::|||||||||||||||||||||||||
Mouse     1 MAVMEVACPGTPGSAVGQQKELAKAKEKTQSLGKKQSCIFKLEAVEKSPVFCGKWEILNDVITKG 65

Human    66 TAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGKMA 130
            |||:|||.||.|||||||||||||||||||||||||||||:||||||||||||||||||||||||
Mouse    66 TAKDGSEGGPPAISIIAQAECENSQEFSPTFSERIFIAGSQQYSQSESLDQIPNNVAHATEGKMA 130

Human   131 RVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQ 195
            |||.:|||..||||||:||.|||||.||||||||||||||||||||||||||||||..|.||..|
Mouse   131 RVCRRGKRHGKARKKRRKKRSKSLAQAGVALAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQ 195

Human   196 FTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPY 260
            |||||..||||.||||:..|||||.|||.||||||||||||||||||||||..||.|.|||||||
Mouse   196 FTKPLGGPGLGHLCFKKQDEGLRPVLPRPELHKLISPLQCLNHVWKLHHPQATGPRPHPTHPFPY 260

Human   261 SRLPHPFPFHPLQPWKPHPLES-FLGKLACVDSQKPLP-DPHLSKLACVDSPKPLPGPHLEPSCL 323
            |.:||||||:||:||||:.|:| .|.|||.|..|:||| .||||:||..||.|||||||||.||.
Mouse   261 SGMPHPFPFYPLEPWKPYMLDSAVLDKLAGVSGQRPLPGPPHLSQLAHGDSQKPLPGPHLESSCP 325

Human   324 SRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKP 388
            ||||.||..|||||||||||||||||||||.||||||::..::.:...|:|||||||||||||||
Mouse   326 SRGALEKVPVEEYLVHALQGSVSSGQAHSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKP 390

Human   389 VDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIV 453
            |||||||||||.|||.|:|||||||||||:|||||||||||||||||||.|||:|||||:|||||
Mouse   391 VDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIV 455

Human   454 PLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKA 518
            |||||||||||||||||||||||||||:|:.|||||||||||||||||||||||:||||||||||
Mouse   456 PLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKA 520

Human   519 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSC 583
            ||||||||||.|||||||||:|||||||||||||||||||||||||||||:|:.||||||:||||
Mouse   521 DNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSC 585

Human   584 CMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELG 648
            |||||||||||||||:|||||||||||||||:|||||||||||||||||||||||:||.||.||.
Mouse   586 CMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELR 650

Human   649 GKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKL 713
            .||.:|||:||||||||:|||||||.||.:||..||||...||| :|      ||:..|..||:.
Mouse   651 RKVGKALQEVGGLKSPWKGEYKEPRPPPQDQATCHQTLPTPPRE-NP------PAKANTDGAPEP 708

Human   714 QPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIGTG 778
            |||||||||||:|:|.|.|||||||.|||||||||:||.|:.||.|:|:||:||.|||||||
Mouse   709 QPPLPPEPPEPSKAPALNLSKEESGTWEPLPLSSLDPATAKGPSFPDRRATLPELELQQLEI--- 770

Human   779 SRGCSGALSTGPGPPAEAGVSLYLRCGLSSSPFPSSSASTDCAGRTPENTASLLPVFHSHLPLFP 843
                                                                             
Mouse   771 ----------------------------------------------------------------- 770

Human   844 AELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARS 908
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||:
Mouse   771 -ELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWNSQAEART 834

Human   909 SSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTK 973
            .|.:..||||||||.||||||||||||||||||||||||||||||||||||||||||.|||||||
Mouse   835 CSCSTALARGRPTDIPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTK 899

Human   974 DGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP 1016
            |||||.||||||||||||||||||||||||:||||||||||||
Mouse   900 DGQPVCYDMEVPDSGIDLQCTLAPDGSFAWTWRVKHGQLENRP 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K14	XP_047292953.1	STKc_NIK	393..660	CDD:270893	239/266 (90%)
Map3k14	NP_058592.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..156		15/19 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..326		24/34 (71%)
		STKc_NIK	395..662	CDD:270893	239/266 (90%)
		Interaction with ZFP91. /evidence=ECO:0000250	403..655		228/251 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..756		68/102 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..823		21/21 (100%)