DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K14 and GckIII

DIOPT Version :9

Sequence 1:	NP_003945.2	Gene:	MAP3K14 / 9020	HGNCID:	6853	Length:	947	Species:	Homo sapiens
Sequence 2:	NP_650596.1	Gene:	GckIII / 42064	FlyBaseID:	FBgn0266465	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	595	Identity:	146/595 - (24%)
Similarity:	207/595 - (34%)	Gaps:	182/595 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   383 TEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE------EL 441
            |||:.|       |:.: |.|.|:|:||||||.:..|.:|....|:|.:.||....|      |:
  Fly     4 TEKVDP-------ELIF-TKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEI 60

Human   442 MACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYL 506
            |..:...||.:...||:..:|..:.|.||.|.|||...|:| .|...|......|.:.|:||:||
  Fly    61 MVLSQCDSPYVTKYYGSFLKGTKLWIIMEYLGGGSALDLMK-AGSFEEMHIGIILREVLKGLDYL 124

Human   507 HSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGR 571
            ||.|.||.|:||.|||||..|. ..|.|||.|     ..|..:....:...||...|||||:...
  Fly   125 HSERKLHRDIKAANVLLSEQGD-VKLADFGVA-----GQLTNTTSKRNTFVGTPFWMAPEVIKQS 183

Human   572 SCDAKVDVWSSCCMMLHMLNG------CHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAI 630
            ..|||.|:||.....:.:..|      .||....|..|     .:.||   ::..|........:
  Fly   184 QYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLIP-----KNNPP---QLTGSYTKSFKDFV 240

Human   631 QEGLRKEPIHRVSAAEL-----------------------GGKVNR----------------ALQ 656
            :..|.|:|.:|.:|.||                       ..||::                |.|
  Fly   241 EACLNKDPENRPTAKELLKYPFIKKAKKNAYLIDLIDRFKKWKVSKGDESETESENSDSDSDAKQ 305

Human   657 QVGGLKSPW----RGEY--KEPRHPPPN-QANYH--------QTLHAQPRELSPRAPG---PRPA 703
            .......||    :|.:  ..||....: |...|        ||.|      ||...|   ..||
  Fly   306 GGSSQDEPWIMTVKGLHINSAPRAGVNSFQLQEHELTMQKLMQTTH------SPAGGGGVQASPA 364

Human   704 EE-------------------TTGRAPKLQPPLPPEPPEP------------------------- 724
            ..                   |..........|||:....
  Fly   365 ANALSSSVSAVAASASSVSVITANEGVSSASALPPQNSHVHNHNHNNINNNNIRNLSNKHATTTM 429

Human   725 -NKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPE---RKATVPEQELQQLEIELFL---NSL 782
             |.:||.:.....|        |:.|....|:.|.||   .::..|..:::.....|.|   :|:
  Fly   430 LNAAPPPSSVTSSS--------SASELQQKRSSSKPELRQSRSAAPLDQVEDRRASLGLPLQSSV 486

Human   783 SQPFSLEEQEQ----------------ILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSW 831
            ..|.:.|:|:|                :.||.|         |..|.|.....:.:..|...||.
  Fly   487 PTPSTAEQQQQRRSSQRESFHANNAALVASCSS---------SSNNHSHEEHVATNHASHVKHSG 542

Human   832 SSQAEARSSS 841
            :.|...:::|
  Fly   543 AGQRLVQTNS 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K14	NP_003945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..171
		STKc_NIK	393..660	CDD:270893	94/317 (30%)
		Interaction with ZFP91. /evidence=ECO:0000269\|PubMed:20682767	401..653		91/286 (32%)
		S_TKc	406..665	CDD:214567	90/309 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..766		29/169 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..830		4/24 (17%)
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	89/286 (31%)
GckIII	NP_650596.1	S_TKc	13..263	CDD:214567	89/265 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910