DRSC/TRiP Functional Genomics Resources

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Protein Alignment MAP3K14 and Slik

DIOPT Version :9

Sequence 1:NP_003945.2 Gene:MAP3K14 / 9020 HGNCID:6853 Length:947 Species:Homo sapiens
Sequence 2:NP_726441.1 Gene:Slik / 37893 FlyBaseID:FBgn0035001 Length:1703 Species:Drosophila melanogaster


Alignment Length:588 Identity:137/588 - (23%)
Similarity:217/588 - (36%) Gaps:167/588 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   406 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMA--------CAGLTSPRIVPLYGA--VR 460
            ||.|:||:|::.:.|:.....|.|..:||   .||.::        .:.:..|.||.||.|  :.
  Fly    43 LGDGAFGKVYKAQHKEQKRFAAAKMCQLE---DEENLSDHMVEIDILSEIKHPNIVELYEAFSID 104

Human   461 EGPWVNIFMELLEGGSLGQLVKE-QGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLS 524
            :..|  :.:|..:||:|..::.| :..|.|.:..|......|||.:||..:::|.|:||.||||:
  Fly   105 DKLW--MLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLT 167

Human   525 SDGSHAALCDFG------HAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSC--------DA 575
            .:|. ..|.|||      |           ::...|...||...||||:||   |        |.
  Fly   168 MEGG-VKLADFGVSAKNKH-----------TMQKHDTFIGTPYWMAPELVL---CETFRDNPYDH 217

Human   576 KVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIP------------------PSC 622
            |||:||....::.:.....|.::.....:.|||....||..|.|                  |..
  Fly   218 KVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQV 282

Human   623 APLT--------------AQAIQEGL---RKEPIHRVSAAELGGKVNRALQ-------------- 656
            .|.|              |:.|::.|   :.|.:..|...|.....|.|||              
  Fly   283 RPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETEEPRNSALQLDLDDDSASLQSQD 347

Human   657 --QVGGLKSPWRGEYKEPRHP-----------------------PPNQANYHQTLHAQPRELSP- 695
              ::.|..:....:.||...|                       .|::.|:.:..:|:.....| 
  Fly   348 IDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKATTPDRPNHTKDDNAEAAAQQPP 412

Human   696 --RAPGPRPAEETTGRAPKL-QPPLPP---------EPPEPNKSPPLTLSKEESGMW-------- 740
              :.|.|.|........|:: |||.||         :.||...:...|..|.||...        
  Fly   413 HTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVAAVAETSEKTESDKKHFVKKGKA 477

Human   741 ----EPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFL-NSLSQPFSLEEQEQILSCLSI 800
                .||.|::.:||.:.:.:||::.||..........||:.: ....:|..........|.:|:
  Fly   478 PPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSV 542

Human   801 DSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPSYFNGVKVQI 865
            .|:            ||.||..::|:.|         .|||.:::.....| .||.:...:..|.
  Fly   543 QSV------------ASSSSSGSVSNAV---------LSSSTSLITINSDP-PTPHHHQPLPPQP 585

Human   866 QSL 868
            |.|
  Fly   586 QHL 588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAP3K14NP_003945.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 135..171
STKc_NIK 393..660 CDD:270893 84/329 (26%)
Interaction with ZFP91. /evidence=ECO:0000269|PubMed:20682767 401..653 80/306 (26%)
S_TKc 406..665 CDD:214567 85/334 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..766 31/151 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 805..830 6/24 (25%)
SlikNP_726441.1 STKc_SLK_like 31..310 CDD:132942 77/286 (27%)
S_TKc 37..295 CDD:214567 74/271 (27%)
PKK 958..1095 CDD:289257
PKK 1126..1266 CDD:289257
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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