DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K14 and Map3k14

DIOPT Version :9

Sequence 1:	NP_003945.2	Gene:	MAP3K14 / 9020	HGNCID:	6853	Length:	947	Species:	Homo sapiens
Sequence 2:	NP_001101771.1	Gene:	Map3k14 / 360640	RGDID:	1310487	Length:	942	Species:	Rattus norvegicus

Alignment Length:	949	Identity:	806/949 - (84%)
Similarity:	855/949 - (90%)	Gaps:	9/949 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITKG 65
            |||||:||||.||||||||||..||||||...|||||.:::||||||||||||||||||||||||
  Rat     1 MAVMEVACPGTPGSAVGQQKEFAKAKEKTQSPGKKQSCIFQLEAVEKSPVFCGKWEILNDVITKG 65

Human    66 TAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGKMA 130
            |||||||.||.|||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat    66 TAKEGSEGGPPAISIIAQAECENSQEFSPTFSERIFIAGSQQYSQSESLDQIPNNVAHATEGKMA 130

Human   131 RVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQ 195
            |||.||||.|||||||:|:.|||||.||||||||||||||||||||||||||||||..|.||..|
  Rat   131 RVCRKGKRHSKARKKRRKRRSKSLAQAGVALAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQ 195

Human   196 FTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPY 260
            ||||||.||||.||||:..|||||.|||.||||||||||||||||||||||..||||.||||||:
  Rat   196 FTKPLKGPGLGHLCFKKQDEGLRPVLPRPELHKLISPLQCLNHVWKLHHPQATGPLPHPTHPFPF 260

Human   261 SRLPHPFPFHPLQPWKPHPLE-SFLGKLACVDSQKPLP-DPHLSKLACVDSPKPLPGPHLEPSCL 323
            ||:||||||:||:||:|:.|. :||.|||.|..|:||| .|||||.|..||.|||||||||.|||
  Rat   261 SRMPHPFPFYPLEPWRPYTLNPAFLDKLAAVSGQRPLPGPPHLSKPAYRDSQKPLPGPHLESSCL 325

Human   324 SRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKP 388
            ||.|.||...||||||||||||||||||||.||||||::..|:.:..||:|||||||||||||||
  Rat   326 SREALEKVPAEEYLVHALQGSVSSGQAHSLASLAKTWSSGSSKLQRFSPETEDNEGVLLTEKLKP 390

Human   389 VDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIV 453
            |||||||||||.|||.|:|||||||||||:|||||||||||||||||||||||:|||||:|||||
  Rat   391 VDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRAEELIACAGLSSPRIV 455

Human   454 PLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKA 518
            |||||||||||||||||||||||||||:|::|||||||||||||||||||||||:.|:|||||||
  Rat   456 PLYGAVREGPWVNIFMELLEGGSLGQLIKQKGCLPEDRALYYLGQALEGLEYLHTHRVLHGDVKA 520

Human   519 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSC 583
            ||||||||||.|||||||||:|||||||||||||||||||||||||||||||:.||||||:||||
  Rat   521 DNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGKPCDAKVDIWSSC 585

Human   584 CMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELG 648
            |||||||||||||||:|||||||||||||||||||||||.||||||||||||||||||.||.||.
  Rat   586 CMMLHMLNGCHPWTQYFRGPLCLKIASEPPPVREIPPSCTPLTAQAIQEGLRKEPIHRASAMELR 650

Human   649 GKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKL 713
            .||.:|||:||||||||:|||||||.||.:||...||||..||| :|      ||:..|..||:.
  Rat   651 RKVGKALQEVGGLKSPWKGEYKEPRPPPQDQAPCPQTLHTLPRE-NP------PAKANTDGAPER 708

Human   714 QPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELF 778
            |||||||||||||:|.|.|||||||.|||||||||:||||:.||.|:|:||.||.||||||||||
  Rat   709 QPPLPPEPPEPNKAPALNLSKEESGTWEPLPLSSLDPAPAKGPSLPDRRATFPELELQQLEIELF 773

Human   779 LNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWN 843
            ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||.:
  Rat   774 LNSLSQPFSLEEQEQILSCLSIDSLSLSEDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSCS 838

Human   844 MVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQP 908
            |.||||||||.||||||||||||||||||||||||||||||||||||||||||.|||||||||||
  Rat   839 MALARGRPTDIPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTKDGQP 903

Human   909 VRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP 947
            |.||||||||||||||||||||||||:||||||||||||
  Rat   904 VCYDMEVPDSGIDLQCTLAPDGSFAWAWRVKHGQLENRP 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K14	NP_003945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		28/35 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..171		30/35 (86%)
		STKc_NIK	393..660	CDD:270893	240/266 (90%)
		Interaction with ZFP91. /evidence=ECO:0000269\|PubMed:20682767	401..653		229/251 (91%)
		S_TKc	406..665	CDD:214567	234/258 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..766		69/103 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..830		23/24 (96%)
Map3k14	NP_001101771.1	STKc_NIK	395..662	CDD:270893	240/266 (90%)
Map3k14	NP_001101771.1	S_TKc	408..667	CDD:214567	234/258 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83677626
Domainoid	1	1.000	667	1.000	Domainoid score	I3909
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2940
Inparanoid	1	1.050	1634	1.000	Inparanoid score	I2306
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37608
OrthoDB	1	1.010	-	-		D162528at2759
OrthoFinder	1	1.000	-	-		FOG0009258
OrthoInspector	1	1.000	-	-		oto129540
orthoMCL	1	0.900	-	-		OOG6_118887
Panther	1	1.100	-	-	LDO	PTHR48016
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X7001
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410