DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K14 and mbt

DIOPT Version :9

Sequence 1:	NP_003945.2	Gene:	MAP3K14 / 9020	HGNCID:	6853	Length:	947	Species:	Homo sapiens
Sequence 2:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	146/562 - (25%)
Similarity:	209/562 - (37%)	Gaps:	123/562 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   166 PRTPEQESCTIPVQEDESPLGAPYVRNTPQFTKPLKEPGLGQLC---FKQLGEGLRPALPRSELH 227
            ||.....:....|.|:|.|..|             ..||:|...   ||.  .|..|:|..:..|
  Fly   150 PRVRRVANVPPSVPEEEGPPAA-------------GTPGVGGASSGGFKP--PGAHPSLLYNSQH 199

Human   228 K----LISPLQCLNHVWKLHH------PQDGGPLPLPTHPFPY------SRLPHPF--------P 268
            .    ...||........|..      |..||.:|......|.      :|..|..        .
  Fly   200 AHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSGGS 264

Human   269 FHPLQP--WKPHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEPSCLSRGAHEKF 331
            :.|:.|  .:....:....|.....:|.|| .||.       .|.|....||..|
  Fly   265 YPPMYPTSHQQQQQQQQQAKQGGDQNQNPL-HPHA-------HPHPHHHQHLAKS---------- 311

Human   332 SVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREE 396
                    |.:.|.|||.|.|....|.  .|.|..:.:|.   :|..   ||.:      ::|..
  Fly   312 --------ASRASSSSGGASSAAQQAS--GASGGAAGQPK---QDQR---LTHE------QFRAA 354

Human   397 VHWAT----------HQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELM-----ACAG 446
            :....          |..::|.||.|.|....||.||.|.||||:.|...:..||:     ....
  Fly   355 LQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRD 419

Human   447 LTSPRIVPLYGA--VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSR 509
            ...|.||..|.:  |.:..||  .||.||||:|..:|.... :.|::......|.|:.|.||||:
  Fly   420 YHHPNIVETYSSFLVNDELWV--VMEYLEGGALTDIVTHSR-MDEEQIATVCKQCLKALAYLHSQ 481

Human   510 RILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCD 574
            .::|.|:|:|::||::|| ...|.|||  .|.|   :.:.|.....:.||...|:|||:......
  Fly   482 GVIHRDIKSDSILLAADG-RVKLSDFG--FCAQ---VSQELPKRKSLVGTPYWMSPEVISRLPYG 540

Human   575 AKVDVWSSCCMMLHMLNGCHPWTQFFRGP---LCLKIASEPPPVREIPPSCAPLTAQAIQEGLRK 636
            .:||:||...|::.|::|..|   ||..|   ...:|....||..:.....:|.....:...|.:
  Fly   541 PEVDIWSLGIMVIEMVDGEPP---FFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVR 602

Human   637 EPIHRVSAAELGGKVNRALQQVG--GLKSPWRGEYKEPRHPP 676
            :|..|.:||||  ..:..|:|.|  .|..|.   .:..||.|
  Fly   603 DPAQRATAAEL--LAHPFLRQAGPPSLLVPL---MRNARHHP 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K14	NP_003945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..171		2/4 (50%)
		STKc_NIK	393..660	CDD:270893	88/288 (31%)
		Interaction with ZFP91. /evidence=ECO:0000269\|PubMed:20682767	401..653		84/271 (31%)
		S_TKc	406..665	CDD:214567	87/270 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..766		4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..830
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	84/273 (31%)
		S_TKc	372..619	CDD:214567	83/260 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910