DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K14 and mig-15

DIOPT Version :9

Sequence 1:	NP_003945.2	Gene:	MAP3K14 / 9020	HGNCID:	6853	Length:	947	Species:	Homo sapiens
Sequence 2:	NP_001024973.1	Gene:	mig-15 / 181248	WormBaseID:	WBGene00003247	Length:	1096	Species:	Caenorhabditis elegans

Alignment Length:	644	Identity:	139/644 - (21%)
Similarity:	225/644 - (34%)	Gaps:	199/644 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   406 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSP-----RIVPLYGA-VREGP- 463
            :|.|::|:|::....:|....|:|.:.:.....:|:.....:...     .:...||| :::.|
Worm    27 VGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPS 91

Human   464 --------WVNIFMELLEGGSLGQLVK--EQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKA 518
                    |  :.||....||:..|||  :.|.|.|:...|...:.|.||.:||..:::|.|:|.
Worm    92 STGKHDQLW--LVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKG 154

Human   519 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSC--------DA 575
            .|||| :|.:...|.|||  |..|   |.|::...:...||...|||||:   :|        |:
Worm   155 QNVLL-TDSAEVKLVDFG--VSAQ---LDKTVGRRNTFIGTPYWMAPEVI---ACDESPEATYDS 210

Human   576 KVDVWSSCCMMLHMLNGCHPWTQFFRGPLC--------LKIASEPPP------------------ 614
            :.|:||.....|.|..| ||       |||        ..|...|||
Worm   211 RSDLWSLGITALEMAEG-HP-------PLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFIET 267

Human   615 --------------------VREIPPSCAPLTAQAIQEGLRKEPIHR------------VSAAE- 646
                                ::|.|..      |.|:..: ||.|.|            .|.:|
Worm   268 VLVKDYHQRPYTGALLRHPFIKEQPHE------QTIRHSI-KEHIDRNRRVKKDDADYEYSGSED 325

Human   647 -------------------------LGGKVNRALQQV----GGLKSPWRGEYKE-PRHPPPNQAN 681
                                     :...:.:..|::    .|...|...:.:. |:.|.|....
Worm   326 DEPSPNNRGPSMGIRDDSESSSMIPMDNTLRKGFQKLQESSRGFAEPGAQQLRRLPQQPAPAPFQ 390

Human   682 YHQTLHAQPR----ELSPRAPGPRPAEETTGRAPKLQP-PLPPEPPEPNKSPPLTLSKEESGMWE 741
            |.|:.:.:||    |:..||...|.|.:....:|..:| |:......|.:|.|......:...:|
Worm   391 YQQSRYVEPRRESSEVKLRAVSSRGAADGPRHSPASRPRPVSHHQRSPQQSHPAAPHLADLANYE 455

Human   742 -------------------PLPL---SSLEPAP--ARNPSSPERKATVPEQELQQLEIELFLNSL 782
                               .:|:   |:..|||  :|..|.|.....|..::|..|..|  |:.:
Worm   456 KRRRSEREERRERERQAHHAMPIARVSASVPAPQQSRKMSEPLLITHVKPEDLDVLASE--LSKM 518

Human   783 SQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSS-RDTLSSGVHSWSSQAEARSSSWNMVL 846
            ....:...:|:.:|         .......|.:||.|| .||:..|  ...:.|:|.......::
Worm   519 GGHHNGRSREESMS---------PPPPAPPPREASISSITDTIDVG--ELDNGADAEWDDLKDIM 572

Human   847 ARGRPT---------DTPSYFNGVKVQIQSL----NGEHLHIREFHRVKVGDIATGISS 892
            ..|..|         .||:  :|....:..:    ||...| ..:...|:.:|..||.|
Worm   573 MNGEGTLRGPNKPLPPTPT--DGENTLVSDVRRNGNGNSGH-GAYKGKKIPEIRPGIIS 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K14	NP_003945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..171
		STKc_NIK	393..660	CDD:270893	80/366 (22%)
		Interaction with ZFP91. /evidence=ECO:0000269\|PubMed:20682767	401..653		79/355 (22%)
		S_TKc	406..665	CDD:214567	81/371 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..766		28/133 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..830		8/25 (32%)
mig-15	NP_001024973.1	STKc_myosinIII_N_like	14..288	CDD:270785	69/279 (25%)
		S_TKc	21..288	CDD:214567	69/279 (25%)
		CNH	773..1076	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910