DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FRMD7 and frm-3

DIOPT Version :9

Sequence 1:	NP_919253.1	Gene:	FRMD7 / 90167	HGNCID:	8079	Length:	714	Species:	Homo sapiens
Sequence 2:	NP_001361874.1	Gene:	frm-3 / 186110	WormBaseID:	WBGene00001490	Length:	1091	Species:	Caenorhabditis elegans

Alignment Length:	766	Identity:	229/766 - (29%)
Similarity:	335/766 - (43%)	Gaps:	194/766 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     4 LKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVK 68
            :||:.|||:..:|.:..|:.|:.|.:..|.||||.|.:||||.|...:||:.||:..|.|.:|:.
Worm    27 IKVRMLDDTVAVFHLGHKAIGQTLLDEVCRHLNLLECDYFGLSFIDINGNHCWLDREKTILRQIT 91

Human    69 N-PKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGD 132
            | ..:..|.|:|||:..:|..|.||.||||||:|||:|||||.|.||||..:|:.::::|||.||
Worm    92 NGSTDAKFYFVVKFYTPNPIDLEEEYTRYLFTMQIKRDLALGELHCSDNTASLLSAYLVQSECGD 156

Human   133 FHEE--TDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPA 194
            |..|  .|..:|:.||::|||.. .:.|:|..|:..||.:|.|||:.:|::||:.|.||::.|.|
Worm   157 FSSEDYPDATYLSHTRFVPNQTLEFQKKVMDNHRNFIGMTPGESDLAMLEVARRCDFYGVKLHAA 221

Human   195 SDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMA 259
            .|.:|....|:|.|:|:.|.|......||:||:|||||||||..|:|||.:.....|:|:||:..
Worm   222 KDIDGNDAALSVMHLGIKVFRQLQLDTTFSWARIRKLSFKRKKLLVKLHPDSYQYLKETVEFSFE 286

Human   260 SRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLP 322
            :||.||.|||.|||:|||||.  :||||.:.:..: ||||||||.||||:||::|.|:...:..|
Worm   287 TRDECKNFWKKCVEHHAFFRCVQAEEPKKETRFFI-SKGSSFRYHGRTQKQLIDYVREHHKRREP 350

Human   323 FERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEV 387
            |.|                .|.|..|.:         .|.|.:..|:....|   ::.||.::
Worm   351 FTR----------------PLRSAASTR---------KGTYSSTYGLVTDRP---TKHRNGSV-- 385

Human   388 TFATELEHSKPEADPTLLHQSQSSSSFPFIYMDPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKF 452
                   :...:.||...||: :.||.|.|                       :.:||......|
Worm   386 -------YEPNQTDPYNKHQN-THSSMPHI-----------------------AHISSQPADHSF 419

Human   453 SGNHMSIYSGLTSKVRPAKQLTYTDVPYIPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERT 517
            ||         |...|..|.:|                                          .
Worm   420 SG---------TLDARVGKSVT------------------------------------------R 433

Human   518 SPHSYVEPTAMKPAERSPRNIRMKSFQQDLQVLQEAIARTSGRS-----NINVGLEEEDPNLEDA 577
            .|.:.|....::..:||.|.|      .|:..: |...|:|.|.     ||:....:|.|:|..:
Worm   434 DPSTSVTQHRLRQLKRSERCI------SDVDTV-ERPQRSSCRPVSHAINISSTSSKEQPDLSVS 491

Human   578 ----------FVC---NIQEQTPKRSQSQSDMKTIR-------------------------FPFG 604
                      .||   .|::..|.:|.|..:.:..|                         ...|
Worm   492 LPNVLSDDLQMVCKEIEIEQNDPPKSVSGDNFQQRRSSRDYDNVSEDSYRLSDHERSTRSEVGVG 556

Human   605 SEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILK-PDYYALYGK 668
            |:|.          .|.:|...|..::..:.::.:..|.......|:|.|...|| ...|..:..
Worm   557 SKFA----------AATIFNSTFVARKPGSNVVKRVVAHTKSTPNSTDDEEGALKSASEYQTFRH 611

Human   669 EIRSPMAR------IRLSSGSLQLDEEDEDA--------YFNTPTAEDRTS 705
            ....|.||      |.:...::.|......|        |.||.|....||
Worm   612 IKEYPFARNANIVPIEIDGPNVDLSARRSPAATTTTTRTYANTTTTVTTTS 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FRMD7	NP_919253.1	B41	3..192	CDD:214604	86/191 (45%)
		FERM_N	6..69	CDD:286467	26/62 (42%)
		FERM_M	88..192	CDD:278785	52/106 (49%)
		FERM_C_FARP1-like	179..299	CDD:270014	59/121 (49%)
		FA	294..327	CDD:285894	19/32 (59%)
frm-3	NP_001361874.1	B41	26..219	CDD:214604	86/191 (45%)
		FERM_C_FARP1-like	206..327	CDD:270014	59/121 (49%)
		FA	320..>353	CDD:370090	18/33 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161469770
Domainoid	1	1.000	110	1.000	Domainoid score	I4358
eggNOG	1	0.900	-	-		E1_KOG3531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224825at33208
OrthoFinder	1	1.000	-	-		FOG0006343
OrthoInspector	1	1.000	-	-		otm15715
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45858
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.810