Protein Alignment FRMD7 and frm-3

DIOPT Version :10

• Sequence 1: NP_919253.1
• Gene: FRMD7 / 90167
• HGNCID: 8079
• Length: 714
• Species: Homo sapiens
• Sequence 2: NP_001427141.1
• Gene: frm-3 / 186110
• WormBaseID: WBGene00001490
• Length: 1091
• Species: Caenorhabditis elegans
• Alignment Length: 766
• Identity: 229/766 - (29%)
• Similarity: 335/766 - (43%)
• Gaps: 194/766 - (25%)

Human     4 LKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVK 68
            :||:.|||:..:|.:..|:.|:.|.:..|.||||.|.:||||.|...:||:.||:..|.|.:|:.
 Worm    27 IKVRMLDDTVAVFHLGHKAIGQTLLDEVCRHLNLLECDYFGLSFIDINGNHCWLDREKTILRQIT 91

Human    69 N-PKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGD 132
            | ..:..|.|:|||:..:|..|.||.||||||:|||:|||||.|.||||..:|:.::::|||.||
 Worm    92 NGSTDAKFYFVVKFYTPNPIDLEEEYTRYLFTMQIKRDLALGELHCSDNTASLLSAYLVQSECGD 156

Human   133 FHEE--TDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPA 194
            |..|  .|..:|:.||::|||.. .:.|:|..|:..||.:|.|||:.:|::||:.|.||::.|.|
 Worm   157 FSSEDYPDATYLSHTRFVPNQTLEFQKKVMDNHRNFIGMTPGESDLAMLEVARRCDFYGVKLHAA 221

Human   195 SDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMA 259
            .|.:|....|:|.|:|:.|.|......||:||:|||||||||..|:|||.:.....|:|:||:..
 Worm   222 KDIDGNDAALSVMHLGIKVFRQLQLDTTFSWARIRKLSFKRKKLLVKLHPDSYQYLKETVEFSFE 286

Human   260 SRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLP 322
            :||.||.|||.|||:|||||.  :||||.:.:..: ||||||||.||||:||::|.|:...:..|
 Worm   287 TRDECKNFWKKCVEHHAFFRCVQAEEPKKETRFFI-SKGSSFRYHGRTQKQLIDYVREHHKRREP 350

Human   323 FERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEV 387
            |.|                .|.|..|.:         .|.|.:..|:....|   ::.||.::
 Worm   351 FTR----------------PLRSAASTR---------KGTYSSTYGLVTDRP---TKHRNGSV-- 385

Human   388 TFATELEHSKPEADPTLLHQSQSSSSFPFIYMDPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKF 452
                   :...:.||...||: :.||.|.|                       :.:||......|
 Worm   386 -------YEPNQTDPYNKHQN-THSSMPHI-----------------------AHISSQPADHSF 419

Human   453 SGNHMSIYSGLTSKVRPAKQLTYTDVPYIPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERT 517
            ||         |...|..|.:|                                          .
 Worm   420 SG---------TLDARVGKSVT------------------------------------------R 433

Human   518 SPHSYVEPTAMKPAERSPRNIRMKSFQQDLQVLQEAIARTSGRS-----NINVGLEEEDPNLEDA 577
            .|.:.|....::..:||.|.|      .|:..: |...|:|.|.     ||:....:|.|:|..:
 Worm   434 DPSTSVTQHRLRQLKRSERCI------SDVDTV-ERPQRSSCRPVSHAINISSTSSKEQPDLSVS 491

Human   578 ----------FVC---NIQEQTPKRSQSQSDMKTIR-------------------------FPFG 604
                      .||   .|::..|.:|.|..:.:..|                         ...|
 Worm   492 LPNVLSDDLQMVCKEIEIEQNDPPKSVSGDNFQQRRSSRDYDNVSEDSYRLSDHERSTRSEVGVG 556

Human   605 SEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILK-PDYYALYGK 668
            |:|.          .|.:|...|..::..:.::.:..|.......|:|.|...|| ...|..:..
 Worm   557 SKFA----------AATIFNSTFVARKPGSNVVKRVVAHTKSTPNSTDDEEGALKSASEYQTFRH 611

Human   669 EIRSPMAR------IRLSSGSLQLDEEDEDA--------YFNTPTAEDRTS 705
            ....|.||      |.:...::.|......|        |.||.|....||
 Worm   612 IKEYPFARNANIVPIEIDGPNVDLSARRSPAATTTTTRTYANTTTTVTTTS 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD7	NP_919253.1	FERM_F1_FRMD7	1..86	CDD:340708	33/82 (40%)
		FERM_B-lobe	94..184	CDD:271216	46/92 (50%)
		FERM_C_FARP1-like	179..299	CDD:270014	59/121 (49%)
		FA	294..327	CDD:462582	19/32 (59%)
frm-3	NP_001427141.1	None