Protein Alignment KCNH7 and sei

DIOPT Version :10

• Sequence 1: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Sequence 2: NP_476713.1
• Gene: sei / 37843
• FlyBaseID: FBgn0003353
• Length: 855
• Species: Drosophila melanogaster
• Alignment Length: 909
• Identity: 413/909 - (45%)
• Similarity: 543/909 - (59%)
• Gaps: 147/909 - (16%)

Human    36 VQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYH 100
            ||.|.:...|:..       ..:..:||...:|......|.:...          ||::
  Fly    19 VQQCELYMSNNNI-------NDNAAKKPPVKEFKRNCPAKSNKFV----------EREL------ 60

Human   101 KNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDNEN--AATPERVNPILPIKTVNRKFFGFKFP 163
               .:.:||.:.|. |.|..|:.: :||.....|.:.  |..|:.|:
  Fly    61 ---FSLMCNLNKIE-KKQVFVSDI-LINASMFDDKKESLARFPKNVS------------------ 102

Human   164 GLRVLTYRK--QSLPQEDPDVVVIDSSKHSDDSVAMK----------HFKSPTKESCSPSEADDT 216
            ....|.|.|  ::.|..|.:.:.:.:...|.:....|          .||...|..|...
  Fly   103 DHNTLVYHKFLRTRPTNDDEALKLKAGGKSKERPGTKITADCFFSPLLFKINNKRECLKK----- 162

Human   217 KALIQPSKCSPLVNISG-PLDHSSPKRQWDRLYPDMLQ--------SSSQLSHSRSRESLCS--- 269
               ::|.|....|..:| ||:....:.:..:.:...::        .:.|:|..|..:.|||
  Fly   163 ---VKPMKGENAVETNGIPLESKPSQHKKQKSFKKCIKCDKKKLYIKNYQVSARRECDLLCSYDP 224

Human   270 IRRASSVHDIEGFGVHPKNIFRDRHASEDNGRNVKVSRSWMAGGPFNHIKSSLLGSTSDSNLNKY 334
            :|:    ::.:.|..|....:      |...:|:|.::   |..|.:::    :|::.|..|:|.
  Fly   225 LRK----NNADLFQTHKGTSY------ECMFKNLKYNQ---AEKPTDNV----MGNSYDDMLDKE 272

Human   335 STINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQ 399
            :.:..           |:|.|...|..                      .:.|||.::|.:.|||
  Fly   273 ALLGS-----------KSEPKGQDPND----------------------MITSLGGNILLDQKLQ 304

Human   400 TPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDL 464
            ....:|:|:||||||||||||:||:||:||||||||.|||||.:::.|:|.....:..|:.::||
  Fly   305 NNYYHKWTLLHYSPFKAVWDWIILILVMYTAIFTPYVAAFLLGEQDYQRRNSKYINSDPIVIIDL 369

Human   465 IVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTT 529
            |||:.||:||:||||||:||..:||||.|.:||:||..||||||:|||:|||||:.||.:|||||
  Fly   370 IVDVTFIVDIIINFRTTFVNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTT 434

Human   530 LIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIG 594
            |||||||||||||||||||:|||||||||||:|||..|.|||||||||||||||.|:...:..||
  Fly   435 LIGLLKTARLLRLVRVARKIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNAEKSIASKNIG 499

Human   595 WLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIG 659
            ||:||...|.:.|.| :.:.|||||.:|:|||||||:||||||||||:|||::||.|:|||||:|
  Fly   500 WLNSLAYDIQEPYFD-NRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVG 563

Human   660 SLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDM 724
            ||||||||||||||||||||||||||.|||||:||||||||||||||||||||||||||||||||
  Fly   564 SLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDM 628

Human   725 NMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTA 789
            |.:|||||||||||||||||:.||..|.||..||.|||||.::|||||||||||.|||.|||||:
  Fly   629 NSLLKGFPECLQADICLHLNRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTS 693

Human   790 LYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLD 854
            |||::||||||.:...:| :|||||||||...:|...||||..||||||||:||:.|:|||:|||
  Fly   694 LYFIARGSIEIQRAGNIV-VLGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLD 757

Human   855 MYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDP 918
            .||||.:.|::||.:|:|:|               |.|.....::.|.|..:|..:..:|.:.|
  Fly   758 SYPEFLESFVSNLVITYNMR---------------DDEHSGVDIKHRYLRAKSSDKMRSSPDIP 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873	16/95 (17%)
		Ion_trans	417..679	CDD:459842	183/261 (70%)
		CAP_ED	753..864	CDD:237999	73/110 (66%)
sei	NP_476713.1	Ion_trans	322..583	CDD:459842	183/261 (70%)
		CAP_ED	657..767	CDD:237999	73/110 (66%)