Protein Alignment KCNH7 and CG42260

DIOPT Version :10

• Sequence 1: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Sequence 2: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Alignment Length: 717
• Identity: 157/717 - (21%)
• Similarity: 299/717 - (41%)
• Gaps: 152/717 - (21%)

Human   418 WDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTY 482
            |..::.:..:|......|..||    :|..:|....:.|     :|.:.|.:::||||.:|||.|
  Fly   583 WSMVVSMAFLYNFWVIIYRFAF----QEINRRTIAIWFC-----LDYLSDFLYLIDILFHFRTGY 638

Human   483 VNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVA 546
            : ::..:.:|..|:..||.... |.||.:..:|.|.|...         ||.....|..|||::.
  Fly   639 L-EDGVLQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYLS---------IGFNSILRSFRLVKIY 693

Human   547 R------KLDRYSEY-----GAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIG---WLD 597
            |      :.:|::.|     ..|::..|:.||    ||..|:::.|      :..:..|   |:
  Fly   694 RFWAFMDRTERHTNYPNLFRSTALIHYLLVIF----HWNGCLYHII------HKNNGFGSRNWV- 747

Human   598 SLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLM 662
                     |:||:|:   .:..:|:.:.|:...:||::| ....|.:..|.:|.|..:|.|.::
  Fly   748 ---------YHDSESA---DVVKQYLQSYYWCTLALTTIG-DLPKPRSKGEYVFVILQLLFGLML 799

Human   663 YASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV 727
            :|::.|:|:.|:..:.:....:..::..||.::|..::||.|:.::.::|.:.|......|....
  Fly   800 FATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDYLWLTQKCSDEERA 864

Human   728 LKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYF 792
            :...|:.|:|:|.::::...|:..:.|:....|.|..|.::.:.....|||.:...|:|...:|.
  Fly   865 VSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPGDYICRKGEVGKEMYI 929

Human   793 LSRGSIEILKDD--IVVAILGKNDIFGE--MVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVL 853
            ::||.::::.|:  .|:|.|.....|||  ::::.....:..|.||::.|.||..:.::|:.:||
  Fly   930 VNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYSDLFVLSKKDMWDVL 994

Human   854 DMYPEFSDHFLTNLELTFNLRHES-AKADLLRSQSMNDSEGDNCK-------------------- 897
            ..||...    ..||.....|.|. .||.|.:.:..|......|:
  Fly   995 KEYPAAR----VRLESIAVKRLEKYKKAPLEKVKYFNVVAMGRCQSTPGLVESCGRTSLEEMWLP 1055

Human   898 ---------------LRRRKLSFESEGEKENSTN--------DPEDSADTIRHYQSSKR------ 933
                           |:::..:.:.:..::.||.        .|...||.:.....|.|
  Fly  1056 PATAGASSLMHHHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLARATDSPRSVSPSA 1120

Human   934 HFEEKKSRS-SSFISSIDDEQKPLFSG-IVDSS-------PGIGKASGLDFEETVPTSG------ 983
            |..|::.|| ::...||..:.:|..:| |.|||       .|:|.|.|    .|.|..|
  Fly  1121 HGSEERPRSRTTSHHSIRPQSQPSHTGHICDSSSQLECYGAGVGGAGG----GTTPLLGSHEVLE 1181

Human   984 --------RMH-IDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYGEV 1039
                    |:| ::..:.:.......:.|:.||...:        ::....|:|.|.|.....|.
  Fly  1182 DEIKRLRERLHTVESENQALNTKLSQQQWDLENRLAE--------IEMQICGVSSTSSVDPENET 1238

Human  1040 EQ 1041
            |:
  Fly  1239 EE 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873
		Ion_trans	417..679	CDD:459842	66/275 (24%)
		CAP_ED	753..864	CDD:237999	30/114 (26%)
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	66/279 (24%)
		CAP_ED	890..1004	CDD:237999	30/117 (26%)