Protein Alignment KCNH7 and Elk

DIOPT Version :10

• Sequence 1: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Sequence 2: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Alignment Length: 1288
• Identity: 384/1288 - (29%)
• Similarity: 588/1288 - (45%)
• Gaps: 356/1288 - (27%)

Human     1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCT 65
            ||.|:|.:|||||||.||..:|:|.:..|::.||:.....|:||:|||.::||:||..:|||.|:
  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65

Human    66 CDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFE 130
            |.||:||:||.....||.::|....|.|:||.:|.|.|:.|.|...|:|:||::...::|:.:.:
  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130

Human   131 YVTD------NENAATPERVNPILPIKTVNRKFFGFKF--------------PGLRVLTYRKQSL 175
            .:|.      |.|    |..:.:..:...   ..|.:|              |||.
  Fly   131 DITHTKMLEMNVN----EECDSVFALTAA---LLGARFRAGSNAGMLGLGGLPGLG--------- 179

Human   176 PQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEAD-DTKA-----LIQPSKCSPLVNISGP 234
                                             .|:.:| ||:|     |..|:.|:
  Fly   180 ---------------------------------GPAASDGDTEAGEGNNLDVPAGCN-------- 203

Human   235 LDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDN 299
                                   :...|||..|         :.:.|           .:..|..
  Fly   204 -----------------------MGRRRSRAVL---------YQLSG-----------HYKPEKG 225

Human   300 GRNVKVSRSWMAGGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDK 364
            |...|:.    .|..|.|                                 .||
  Fly   226 GVKTKLK----LGNNFMH---------------------------------STE----------- 242

Human   365 TIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYT 429
               ||                       .||||.|:.:.::..:.||..||.:|||:||:...|.
  Fly   243 ---AP-----------------------FPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYV 281

Human   430 AIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPA 494
            |:..||:|||...||:.:             |.|:||:.:||:|||:|||||:|::..||||:..
  Fly   282 ALMVPYNAAFAKADRQTK-------------VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSK 333

Human   495 KIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAV 559
            :|||:|.:|||.:|::||:|||.|......|...:.|.|:|..|||||.|:.:|:||||::.|.:
  Fly   334 QIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMI 398

Human   560 LMLLMCIFALIAHWLACIWYAIGNVERPYLTD-KIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYV 623
            |.|||..|.|.|||||||||.|...|..:..: .||||    |.:.:|.|.|.:..  :..:.|.
  Fly   399 LTLLMFSFTLAAHWLACIWYVIAVKEYEWFPESNIGWL----QLLAERKNASVAIL--TTAETYS 457

Human   624 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQM 688
            |||||||:|||||||||||.||.:||:|:|.:||||:||:|.:||||:|||||:||..:.|..:.
  Fly   458 TALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKW 522

Human   689 LRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKA 753
            ..:|:|:..|.:|..|:||:|:|||.:|:.::|||:...|:.|||.|:.|:.:||::.:|| ...
  Fly   523 RDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREILQ-LPI 586

Human   754 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGE 818
            |..||:|||:.|::..||....||:.|:|.||.|..:|:|..||:|::|||:|||||||.|:.|.
  Fly   587 FEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGS 651

Human   819 --MVHLYAKPG----------------KSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLT 865
              .|||.|...                :|::|::|||||||..|....|:|||.:|||:...|..
  Fly   652 DINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFAN 716

Human   866 NL--ELTFNLR--HESAKADLLRSQSM-NDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTI 925
            ::  :||.|||  :|:..:|:..|..: :.||.|.   .|.:.....:|||||. ..|...|..:
  Fly   717 DIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDE---NREEAEEGGKGEKENG-GGPPSGASPL 777

Human   926 RHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKASGLDFEETVPTSGRMHIDKR 990
            .:..:|..|                          ...||.:|..|        |.:.|:|  :|
  Fly   778 HNISNSPLH--------------------------ATRSPLLGMGS--------PRNQRLH--QR 806

Human   991 SHSCKDITDMRSWERE-NAHPQPEDSSPSALQRAAWGISE-TESDLTYGEVEQRLDLLQEQLNRL 1053
            ..|...:.:.....|. ||        ..:|.|.::...| .|.:.:.|.....|:.|..|::.|
  Fly   807 GRSLITLRETNKRHRTLNA--------ACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTL 863

Human  1054 E---SQMTTDIQTILQLLQKQTTV-----------VPPAYSM----------------------V 1082
            .   :|::.:::..:..||:.|..           .|||.|:                      |
  Fly   864 HQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGV 928

Human  1083 TAGSEYQRPIIQLMRTSQ--PEA---SIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLN- 1141
            .|.:|    :..:.|:|.  ||.   .::...|.:.||:.|..::.:|: :.|:.|.:....::
  Fly   929 LAAAE----LAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKT-MTSRSSQTDFYRIDF 988

Human  1142 -------TASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTV 1187
                   .|:...:..||..:..:..|:.|.|:|        .:|..|.|:|:
  Fly   989 PTFERFVLANPRLVLGLLGIEPAIKNEMDLLQQK--------QTLQISPLNTI 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873	38/95 (40%)
		Ion_trans	417..679	CDD:459842	129/262 (49%)
		CAP_ED	753..864	CDD:237999	54/128 (42%)
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	38/92 (41%)
		PLN03192	270..>650	CDD:215625	189/399 (47%)
		cNMP	586..716	CDD:197516	55/129 (43%)