Protein Alignment KCNH7 and Ih

DIOPT Version :10

• Sequence 1: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Sequence 2: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Alignment Length: 883
• Identity: 205/883 - (23%)
• Similarity: 347/883 - (39%)
• Gaps: 228/883 - (25%)

Human   186 DSSKHSDDSVAMKHFKSPTKESCSP-SEADDTKALIQPSKCSPLVNISGPLDHSSP----KRQWD 245
            |.:.||..:.:.:...|...|...| .|:..|.|         ...:|.|..:|.|    .....
  Fly   511 DYTHHSSSNGSQQEGSSEANEGHEPVGESTITVA---------SAGVSYPHPYSYPYHYAHHASS 566

Human   246 RLYPDMLQSSSQLSHSRSRESLCSI-RRASSVHDIEGFGVHPKNIFR------DRHASEDNGRNV 303
            ...|..|::|.|| ||......|.. .|.:|......|  :.::|.|      ||..|.|:..:|
  Fly   567 ATAPANLKASLQL-HSFGSHHPCPYPARPTSTSCTNSF--NRRHIRRHKGKLGDRLLSGDSEESV 628

Human   304 KVSRSWMAGGPFNHIKSSLLGSTSDS-----------------------NLNKYSTINKIP---- 341
            :.|...:.....|.::.|...:.:||                       :::.|.|..:.|
  Fly   629 RCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNI 693

Human   342 -----QLTLNFSEVKTEKKNSSPPSSDKTIIAPKV-KDRTHNVTEKVTQVLSLGADVLPEYKLQT 400
                 :::.||  :|::.::...|:.::  :|.|: ..|...|.|::.|..|
  Fly   694 PIVSEKVSANF--LKSQLQSWFQPTDNR--LAMKLFGSRKALVKERIRQKTS------------- 741

Human   401 PRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLI 465
               ..:.|...|.|:..||..:|||::...|..|.:.:| .||  :...|...::|        :
  Fly   742 ---GHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISF-FND--DLSTRWIAFNC--------L 792

Human   466 VDIMFIIDILINFRTTYVNQN--EEVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFG----- 521
            .|.:|:|||::||||..:.|:  |:|:.||..||.||.:.||.:|::::||.|  .|||.
  Fly   793 SDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKL 857

Human   522 -SGSDETTTL-----IGLLKTARLLRLVRVAR--KLDRYSEYGAAVLML---------------- 562
             ..||....|     :.:|:.|:||.|||:.|  :|.||......|.:|
  Fly   858 QDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNR 922

Human   563 ---------------------------LMCIFALIAHWLACI--------------WYAIGNVER 586
                                       |:|:..||.||..|:              |.:|..::.
  Fly   923 KDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQE 987

Human   587 PYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIF 651
            .|      ||                       ::|..||:...|.:..:|:|...|.:.::...
  Fly   988 SY------WL-----------------------EQYSWALFKAMSHMLCIGYGRFPPQSLTDMWL 1023

Human   652 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 716
            ::..|:.|:..||...|:.:.:||.|.|...:|..::.:|:|::.:.::|..:|||:.|||:|.:
  Fly  1024 TMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRY 1088

Human   717 TYTNG--IDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDT 779
               .|  .|..::|....|.|:.|:..:..::|:.:...|..|....:..:..|.|.....|||.
  Fly  1089 ---QGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDI 1150

Human   780 LVHCGDVLTALYFLSRGSIEI-LKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHK 843
            ::..|.:.|.:||:..|.::| :.:..|...|.....|||:..|  ...:..|.|||.|||:|..
  Fly  1151 IIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLL--TNARRVASVRAETYCNLFS 1213

Human   844 IQREDLLEVLDMYP-------EFSDHFLTNLELTFNLRHESAKADLLRSQSMND---------SE 892
            :..:....|||.||       ..:...|..:....|:.|:  |.:.|.:...|.         :|
  Fly  1214 LSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQ--KDEQLSNPESNTITAVVNALAAE 1276

Human   893 GDNCKLRRRKLSFESEGEKENSTNDPEDS----ADTIR 926
            .|:||.....|       |||..:..|.|    ..|||
  Fly  1277 ADDCKDDDMDL-------KENLLHGSESSIAEPVQTIR 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873
		Ion_trans	417..679	CDD:459842	82/335 (24%)
		CAP_ED	753..864	CDD:237999	32/118 (27%)
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	9/59 (15%)
		PLN03192	741..>1214	CDD:215625	132/533 (25%)