Protein Alignment KCNH7 and Cngl

DIOPT Version :10

• Sequence 1: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Sequence 2: NP_727848.3
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Alignment Length: 1047
• Identity: 217/1047 - (20%)
• Similarity: 394/1047 - (37%)
• Gaps: 240/1047 - (22%)

Human   246 RLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNGRNVKVSRSWM 310
            |.:..|::.....|.:.|.:|....:|.|.:.|               .||:.:....:.::.||
  Fly   116 RHHHKMVRDDDNNSAAHSSDSKSPSQRKSRIGD---------------GASDPDSDWTRSNQRWM 165

Human   311 AGGPFNHIKSSLLG----STSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKV 371
            .......|.|::..    ...||.|.::|| .:||:     ::...|...|...|.|   :...|
  Fly   166 KLRTTVQISSAIQKKPPLKREDSFLKRFST-RQIPE-----TQETVEDTGSESASGD---VDKSV 221

Human   372 KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV-----IYTAI 431
            |.|...:.::.:.|              .|..|.:           :.||::|.|     ::|.|
  Fly   222 KRRRRYLQKRRSVV--------------NPDENFY-----------FYWLMMLTVCVLYNLWTLI 261

Human   432 FTPYSAAFLLNDREEQKRRECGYSCSPLNVV-DLIVDIMFIIDILINFRTTYVNQNEEVVSDPAK 495
            .             .|...|...|.....:: |.:.|::||:||::..||.|:.|. .:|.|..|
  Fly   262 V-------------RQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYLEQG-LMVYDDRK 312

Human   496 IAIHYFKGW-FLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAV 559
            :|.||.... |:.||:|.||.|||....|:..........|..|.:|...:......:......|
  Fly   313 LACHYVHSRDFIFDMIALIPLDLLQLKMGTHPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVV 377

Human   560 LMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVT 624
              .|:.|..::|||..|.::.:...| .:..|   |:        ..|...|.:   ::..||:.
  Fly   378 --NLIHILLILAHWFGCFYFLLSEAE-GFQGD---WV--------YPYRPGDYA---TLTRKYLG 425

Human   625 ALYFTFSSLTSVGFGNVSPNTNSEK----------------------------IFSICVMLIGSL 661
            :||::..:||::| ...:|.||:|.                            ||:|...|||..
  Fly   426 SLYWSTLTLTTIG-DLPTPETNAEPNFSVDGPRSIPRRGIKSRLLQFGSSYGYIFTIVSYLIGVF 489

Human   662 MYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT---YTNGID 723
            ::|:|.|.|..:|....:....:...:...|.::|.|::|..:::|:..::.::|:   ...|.|
  Fly   490 IFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGD 554

Human   724 MNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT 788
            :|..|...|:.|:.::.||:|.::|:....|:......|..|.:|.|.....|||::...|:|..
  Fly   555 INTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAR 619

Human   789 ALYFLSRGSIEILKD-DIVVAILGKNDIFGEMVHLYAKP-GKSNADVRALTYCDLHKIQREDLLE 851
            .::.::.|.:|:|.: ..|:..:...|.|||:..|.... .|..||||::.|.:|..:.|||:|.
  Fly   620 EMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLA 684

Human   852 VLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEK-ENST 915
            .:..||:                          :|.:..:.|     |:|.:......:| ..:.
  Fly   685 AMKDYPD--------------------------AQEILQTLG-----RKRLMEVRCVNKKYAKAQ 718

Human   916 NDPEDSADTIRHYQSSKRHFE--------EKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKA-S 971
            :|.|.:|....|....:.|.:        .:.|.|...:..:..:.|. |..::..|....|: .
  Fly   719 SDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKG-FRNVLKKSRTSRKSDE 782

Human   972 GLDFE---ETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESD 1033
            .|:.:   .|.|...::.:.:.|....|..|..|.|   |..:..|.:||.:....
  Fly   783 SLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAE---AKDELHDKTPSPIGAGL--------- 835

Human  1034 LTYGEVEQRLDLLQEQLNRLESQMTTD-------IQTILQLLQK---QTTVVPPAYSMVTAGSEY 1088
                .:.|||.||:|:...::.:...:       ||.:.||..|   |.....|...||
  Fly   836 ----PLLQRLRLLKEKQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMV------ 890

Human  1089 QRPIIQLMRTSQPEASIKTDRSFSPS-------------------------SQCPEFLDLE-KSK 1127
                     .:.|..|.|.|..|:.|                         :|....:.:. |.|
  Fly   891 ---------NTPPNISSKIDSHFAASQAGASHPGPNGGAIGISAPGQSLTVAQIKPIMKVSFKQK 946

Human  1128 LKSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGL 1192
            ::..:....|.  :::...:..::.|::...||.| :.:..|...|:....|...|.|:.||..:
  Fly   947 IQQMQGGGGGA--SSSPGPSTGAIAKKEPPKSLAL-VAKHATSEDPVAAAGLGLGSGSSSGIATI 1008

Human  1193 HRHVSDP 1199
            .:.|..|
  Fly  1009 SKRVVKP 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873
		Ion_trans	417..679	CDD:459842	72/296 (24%)
		CAP_ED	753..864	CDD:237999	32/112 (29%)
Cngl	NP_727848.3	Ion_trans	240..509	CDD:459842	73/311 (23%)
		CAP_ED	584..696	CDD:237999	33/137 (24%)
		dermokine	<1688..>1775	CDD:455732