Protein Alignment KCNH7 and eag

DIOPT Version :10

• Sequence 1: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Sequence 2: NP_001036275.1
• Gene: eag / 32428
• FlyBaseID: FBgn0000535
• Length: 1270
• Species: Drosophila melanogaster
• Alignment Length: 1266
• Identity: 369/1266 - (29%)
• Similarity: 552/1266 - (43%)
• Gaps: 361/1266 - (28%)

Human     4 RRGHVAPQNTFLGTIIRKFEGQ-NKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPC--T 65
            |||.||||||||..|||:...| :..|::|||::.:..|:|||:.||:::|::|.:||||.|  .
  Fly     5 RRGLVAPQNTFLENIIRRSNSQPDSSFLLANAQIVDFPIVYCNESFCKISGYNRAEVMQKSCRYV 69

Human    66 CDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICN-----------------THII 113
            |.|::|..|.:..:.::...|...::.:.|:..|.||.....|.                 ..:.
  Fly    70 CGFMYGELTDKETVGRLEYTLENQQQDQFEILLYKKNNLQCGCALSQFGKAQTQETPLWLLLQVA 134

Human   114 PVKNQEGVAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQE 178
            |::|:..:.::|::.|..:|
  Fly   135 PIRNERDLVVLFLLTFRDIT--------------------------------------------- 154

Human   179 DPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSPKRQ 243
                             |:|          .|.:::|||.::..||.:.|..
  Fly   155 -----------------ALK----------QPIDSEDTKGVLGLSKFAKLAR------------- 179

Human   244 WDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNGRNVKVSRS 308
                           |.:|||:                |..|
  Fly   180 ---------------SVTRSRQ----------------FSAH----------------------- 190

Human   309 WMAGGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKD 373
                                                                       .|.:||
  Fly   191 -----------------------------------------------------------LPTLKD 196

Human   374 RTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAA 438
            .|..  ..:..::||.||::|:|:.:.|:.....:|||..|||:|||:||.|..||||..||:.|
  Fly   197 PTKQ--SNLAHMMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPYNVA 259

Human   439 FLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKG 503
            |.....|:..          |.|||.|||::|.|||::||.||:|....||||||..|.::|.|.
  Fly   260 FKNKTSEDVS----------LLVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYLKS 314

Human   504 WFLIDMVAAIPFDLL-IFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIF 567
            ||:||:::.:|:|:. .|....|...:|...||..|||||.||.||||||.|||||:|:||:|.:
  Fly   315 WFIIDLLSCLPYDVFNAFDRDEDGIGSLFSALKVVRLLRLGRVVRKLDRYLEYGAAMLILLLCFY 379

Human   568 ALIAHWLACIWYAIGNVERPYLTD---KIGWLDSLGQQIGKRY-----NDS--DSSSGPSIKDKY 622
            .|:|||||||||:||..:    .|   :..||..|.......|     ||:  :..:|||.|..|
  Fly   380 MLVAHWLACIWYSIGRSD----ADNGIQYSWLWKLANVTQSPYSYIWSNDTGPELVNGPSRKSMY 440

Human   623 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQ 687
            |||||||.:.:||||||||:..|::||:|:||:|:|.:|:||:|||:|:.|||::.|.||:||..
  Fly   441 VTALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYATIFGHVTTIIQQMTSATAKYHDM 505

Human   688 MLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCK 752
            :..|:||::.|::|..|.:|:.:|....|..|.|:|...||...|:.::||||:|||:.:.....
  Fly   506 LNNVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDTEKVLNYCPKDMKADICVHLNRKVFNEHP 570

Human   753 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFG 817
            |||.||.||||||||.|..:|:.|||.|.|.|:.:.:|.|:..||:|:::||.|||||||.|:||
  Fly   571 AFRLASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCFIVTGSLEVIQDDEVVAILGKGDVFG 635

Human   818 EMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHE---SAK 879
            :.....:..|:|.|:||||||||||.|:|:.||||||.|..|::.|..||.||:||||.   ...
  Fly   636 DQFWKDSAVGQSAANVRALTYCDLHAIKRDKLLEVLDFYSAFANSFARNLVLTYNLRHRLIFRKV 700

Human   880 ADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSS 944
            ||:.|.:.:.:         |||          |....|::....:|...|..|...:.::.|..
  Fly   701 ADVKREKELAE---------RRK----------NEPQLPQNQDHLVRKIFSKFRRTPQVQAGSKE 746

Human   945 FISSIDDEQKPLFSGIVDSSPGIGKASGLDFEET-VPTSGRMHIDKRSHSCKDITDMRSWERENA 1008
            .:..         ||..|...|.|     :.|.| :|....:..|.|      |....:....:.
  Fly   747 LVGG---------SGQSDVEKGDG-----EVERTKLPAKLTLTEDAR------ILSTAAAPSPSP 791

Human  1009 HPQPEDSSPSALQRAA--WG----------ISETESDLTYGEVEQRLDLLQEQLNRLESQMTTD- 1060
            .|.|....|||....|  ||          .|:|.:.:.........:.|:|...:.....|:.
  Fly   792 SPSPSSGPPSARSTRASKWGRLLGSSSVDSASDTSAKVAVSRSLSARESLRESTAQARQSSTSSS 856

Human  1061 --------------IQTILQLLQKQTTV--------VPP-----------AYSMVTAGSEYQRPI 1092
                          :|.....|.:|.|:        .||           |.|..|.|     |.
  Fly   857 NGGQGNKVFPKAPKLQASQATLARQDTIDEGGEVDSSPPSRDSRVVIEGAAVSSATVG-----PS 916

Human  1093 IQLMRTSQPEAS-----------------IKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVH- 1139
            ..:..||...|.                 .|.||:.:...:  ..:::..|:..:.::..:|:.
  Fly   917 PPVATTSSAAAGAGVSGGPGSGGTVVAIVTKADRNLALERE--RQIEMASSRATTSDTYDTGLRE 979

Human  1140 --LNTASEDNLTSLLKQDSDLSLELHLRQRK 1168
              ...|..|.:.::|....|:.|||...|::
  Fly   980 TPPTLAQRDLIATVLDMKVDVRLELQRMQQR 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873	27/114 (24%)
		Ion_trans	417..679	CDD:459842	130/272 (48%)
		CAP_ED	753..864	CDD:237999	61/110 (55%)
eag	NP_001036275.1	PAS_9	40..155	CDD:463873	28/176 (16%)
		Ion_trans	238..499	CDD:459842	131/274 (48%)
		CAP_ED	571..682	CDD:237999	61/110 (55%)