Protein Alignment ACVR1 and acvr1

DIOPT Version :9

• Sequence 1: NP_001096.1
• Gene: ACVR1 / 90
• HGNCID: 171
• Length: 509
• Species: Homo sapiens
• Sequence 2: NP_001017357.1
• Gene: acvr1 / 550111
• XenbaseID: XB-GENE-478850
• Length: 512
• Species: Xenopus tropicalis
• Alignment Length: 512
• Identity: 417/512 - (81%)
• Similarity: 463/512 - (90%)
• Gaps: 3/512 - (0%)

Human     1 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHV 65
            |||||||||:|:|:|..|||||||:.|:|...|.|||||:|||:.|||.|||||:|||.|||..|
 Frog     1 MVDGVMILPILMMVAFSSPSMEDEEMKLNAGQYKCVCEGMSCGSGDHCYGQQCFASLSNNDGVLV 65

Human    66 YQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQL-PTKGKSFPG-TQNFHLE-VGLI 127
            .||||||||||||||||||||..|||||||.|.||.|||.:: ...|::..| ..|:.:| :.:.
 Frog    66 SQKGCFQVYEQGKMTCKTPPSQDQAVECCQSDLCNMNITVKITDLTGRTKQGEAPNYSVETLTIF 130

Human   128 ILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGS 192
            ||:.|..:.:|:.|..:..||.::|:.:.|:.||.|||||:|||.:||||||||::|||||||||
 Frog   131 ILAPVIVLVVLSVLAVLIFRKIQQRHMQMLSNRDAEYGTIDGLIASNVGDSTLAEMLDHSCTSGS 195

Human   193 GSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVML 257
            ||||||||||||||||||.||||||||||||||.||||:||||||||||||||||||||||||:|
 Frog   196 GSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLL 260

Human   258 RHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIE 322
            ||||||||||||||||:|||||||||||||:||||||||:||||:|:||||||||||||||||:|
 Frog   261 RHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVE 325

Human   323 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVL 387
            ||||||||||:||||||||:|||||||||||||||||||||:|||||||||||||||||||||||
 Frog   326 IFGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLDVGNNPRVGTKRYMAPEVL 390

Human   388 DETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ 452
            |||||||||||||||||:||||||||||||||||||||:||||||||||||||||||:|||||||
 Frog   391 DETIQVDCFDSYKRVDIYAFGLVLWEVARRMVSNGIVEEYKPPFYDVVPNDPSFEDMKKVVCVDQ 455

Human   453 QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
            ||||||||||||||||:|||||||||||||||||||||||||||||||||||||:||
 Frog   456 QRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKSDC 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1	NP_001096.1	Activin_recp	37..103	CDD:395845	51/65 (78%)
		TGF_beta_GS	179..206	CDD:400699	24/26 (92%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	279/296 (94%)
acvr1	NP_001017357.1	Activin_recp	33..104	CDD:279413	55/70 (79%)
		TGF_beta_GS	182..209	CDD:285687	24/26 (92%)
		STKc_ACVR1_ALK1	205..502	CDD:271044	279/296 (94%)
		S_TKc	215..496	CDD:214567	264/280 (94%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	567	1.000	Domainoid score	I2772
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7
Inparanoid	1	1.050	858	1.000	Inparanoid score	I3985
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111967at7742
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		oto150730
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060