Protein Alignment ACVR1 and put

DIOPT Version :10

• Sequence 1: NP_001096.1
• Gene: ACVR1 / 90
• HGNCID: 171
• Length: 509
• Species: Homo sapiens
• Sequence 2: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 176/533 - (33%)
• Similarity: 257/533 - (48%)
• Gaps: 103/533 - (19%)

Human    23 DEKPKVNPKLYMC----VCEGLSCGNEDHCEGQ-----QCFSSLSINDG---FHVYQKGCF-QVY 74
            |||        ||    .||    ...:||:.:     .|:...|:|:.   ..:..|||| .::
  Fly    40 DEK--------MCNTTQQCE----TRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMH 92

Human    75 EQGKMTCKTPPSPGQA---VECCQGDWCNRN---------ITAQLPTKGKSFPGTQNFHLEVGLI 127
            |..:..|.|...|.|.   ..||:|..||.|         .|.|:| |.|:..|:...::.:|..
  Fly    93 ECNQTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVP-KEKTQDGSNLIYIYIGTS 156

Human   128 ILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGS 192
            :.||      |..::|:.|..::||.|...|    |..|.|..||.:      :.||.:
  Fly   157 VFSV------LMVIVGMGLLLYRRRKQAHFN----EIPTHEAEITNS------SPLLSN------ 199

Human   193 GSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVML 257
                         |.|.|||....||:|:||:.....::||||||..::::||..|.::|....:
  Fly   200 -------------RPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRM 251

Human   258 RHENILGFIASDMTSRH-SSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHI 321
            ||.|||.|:.   ..:| ...:.|||:.|...|||.|||:..|:......||..|:|:||||||.
  Fly   252 RHPNILEFLG---VEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHE 313

Human   322 EI--FGTQG-KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 383
            ||  ..|.| ||:|||||.||||:|:|.:...||||.|||::........|  .:.:|||:||||
  Fly   314 EIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGD--THGQVGTRRYMA 376

Human   384 PEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVV 448
            ||||:..|..: .|::.|:|::|.||||||:..|....|.|.:::.||...:...||.:::::.|
  Fly   377 PEVLEGAINFN-RDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESV 440

Human   449 CVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARL-----------------TALRIKKTLT 496
            .:.:.||.:.|.|.:.|.|......|:|||..:..|||                 |.|.||.. |
  Fly   441 VMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPSTQLLIKNH-T 504

Human   497 KIDNSLDKLKTDC 509
            .||::  |..|:|
  Fly   505 NIDDA--KESTNC 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1	NP_001096.1	TFP_LU_ECD_ALK2	33..103	CDD:467065	24/94 (26%)
		TGF_beta_GS	179..206	CDD:462503	2/26 (8%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	121/317 (38%)
put	NP_001262575.1	TFP_LU_ECD_ACVR2	33..125	CDD:467135	27/96 (28%)
		STKc_ACVR2	206..493	CDD:270955	112/292 (38%)