Protein Alignment ACVR1 and babo

DIOPT Version :10

• Sequence 1: NP_001096.1
• Gene: ACVR1 / 90
• HGNCID: 171
• Length: 509
• Species: Homo sapiens
• Sequence 2: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 254/535 - (47%)
• Similarity: 335/535 - (62%)
• Gaps: 55/535 - (10%)

Human     7 ILPVL-IMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDH-CEGQQ-CFSSLSIN-DGFHVYQ 67
            :.|.| |.||.||....:.|.|       |.|:  :|...:: ||... ||:|:..| ||..::.
  Fly   107 VTPQLPIYIAQPSAKKPENKIK-------CHCD--TCKESNNICETDGFCFTSVEKNSDGSIIFS 162

Human    68 KGCF---QVYEQGK-MTCK---------TPPSPGQAVECCQG-DWCNRNITAQLPTK-------- 110
            ..|.   |::..|: :.|.         .|.....|..||:. |:|||.:..:  ||
  Fly   163 YRCLHKSQIFPPGRSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPK--TKDQRSDRVE 225

Human   111 -GKSFPGTQNF--HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPR-----DVEYGTI 167
             |:.. ..|::  |.......::::....|..|..|.:...:.:|.:...:.|     |..|..|
  Fly   226 EGRQI-SVQDYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYDPI 289

Human   168 EGLITTNVGDSTLADLLDHSCTSGSGS-GLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGEN 231
            ..      |::|:.|:::.: |||||| |||.||||::|||:.|...:||||:||||||.|:|||
  Fly   290 LN------GNTTIHDIIEMT-TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGEN 347

Human   232 VAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQ 296
            |||||||||:|.|||||.|:|.||||||||||||||:|.....:.|||||:|.|||.|||:|||.
  Fly   348 VAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLT 412

Human   297 LTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMH 361
            ...:||.:.|.:.||||:||||||::|.||:||||||||||||||||||.|..|.|.||||||.|
  Fly   413 THPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRH 477

Human   362 SQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVED 426
            .:..:.:|:.:..|||||||||||||||::....||||||.|::||||:|||:|||.....|.::
  Fly   478 VEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDE 542

Human   427 YKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRI 491
            |:.|:||||..|||.|:|:||||:::.||||||||.:...|.::||:||||||.||.||||||||
  Fly   543 YQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRI 607

Human   492 KKTLTKIDNSLDKLK 506
            ||||..|... ||:|
  Fly   608 KKTLASISVE-DKVK 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1	NP_001096.1	TFP_LU_ECD_ALK2	33..103	CDD:467065	23/86 (27%)
		TGF_beta_GS	179..206	CDD:462503	15/27 (56%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	190/296 (64%)
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	22/91 (24%)
		GS	294..324	CDD:197743	17/30 (57%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	185/286 (65%)