DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACVR1 and sax

DIOPT Version :9

Sequence 1:	NP_001096.1	Gene:	ACVR1 / 90	HGNCID:	171	Length:	509	Species:	Homo sapiens
Sequence 2:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	271/513 - (52%)
Similarity:	341/513 - (66%)	Gaps:	47/513 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    24 EKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN-DGFHVYQKGCFQVYEQGKMTCK----- 82
            |.|..:|..:...|:          ...||:.|.:.: ||.....:||....:|..|.|.
  Fly    83 EPPCRDPYEFTHTCQ----------NAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLK 137

Human    83 -TPPSPGQA-----VECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLI---------ILSVV 132
             ..||....     |.||.||:||.....:|      .|...|   :|.:|         :|..|
  Fly   138 INGPSKRNTGKFVNVVCCAGDYCNEGDFPEL------LPFDSN---DVTVITADTSSISKMLVAV 193

Human   133 FAVCLLACLLG-VALRKFKRRNQERL----NPRDVEYGTI--EGLITTNVGDSTLADLLDHSCTS 190
            ....|:..||| |.:...:|.:::||    ..:|.|...:  |.|..|:.|||||.:.|.||.||
  Fly   194 LGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTS 258

Human   191 GSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTV 255
            |||||||.|||||:|:|:||:||:|:|:|||||||.|.||::|||||.||||:||.||||:|:|:
  Fly   259 GSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTI 323

Human   256 MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLH 320
            :||||||||||.||||||:|.|||||:|||:.:|||:|:|....|.....:.|.||||:||.|||
  Fly   324 LLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLH 388

Human   321 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE 385
            .||||.|||||:||||||||||||..||.|.|||.||||.||..|.|||:||||:||||||||||
  Fly   389 TEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPE 453

Human   386 VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV 450
            ||||:|.::||::.:|.||:|||||||||.||.:|.||.|:||.|||||||.||||||||||||:
  Fly   454 VLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCI 518

Human   451 DQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTD 508
            |..||:|||||.||..:|.::|||||||:|||..||.|||||||:.|:.::.:|::.|
  Fly   519 DNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLD 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1	NP_001096.1	Activin_recp	37..103	CDD:395845	20/77 (26%)
		TGF_beta_GS	179..206	CDD:400699	19/26 (73%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	206/296 (70%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	23/94 (24%)
		TM_EGFR-like	182..218	CDD:213052	8/35 (23%)
		TGF_beta_GS	247..274	CDD:285687	19/26 (73%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	206/296 (70%)
		TyrKc	276..553	CDD:197581	192/276 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	427	1.000	Domainoid score	I603
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1347
Isobase	1	0.950	-	0	Normalized mean entropy	S3081
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm41790
orthoMCL	1	0.900	-	-		OOG6_107567
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5088
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810