DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACVR1 and acvr1l

DIOPT Version :9

Sequence 1:	NP_001096.1	Gene:	ACVR1 / 90	HGNCID:	171	Length:	509	Species:	Homo sapiens
Sequence 2:	NP_571420.1	Gene:	acvr1l / 30615	ZFINID:	ZDB-GENE-990415-9	Length:	506	Species:	Danio rerio

Alignment Length:	486	Identity:	333/486 - (68%)
Similarity:	383/486 - (78%)	Gaps:	18/486 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    35 CVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWC 99
            |:|.|..| ||..|.|.||::|:.|::....:::||.......:|||....|....||||....|
Zfish    28 CMCVGSDC-NEQQCTGDQCYTSVIISNDVTTFKRGCLIGPASKRMTCSATASASHVVECCSQHMC 91

Human   100 NRNITAQL--------PTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVAL---RKFKRRN 153
            |.|::.:.        |.:.|:      .|..|.:::|.|:....:|..|..:||   |:.....
Zfish    92 NANVSKETLLRLLLTSPEEKKT------VHYRVEMLVLFVLGPFVVLGLLSFLALLVCRRLHHGR 150

Human   154 QERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGR 218
            .|||:..|.|.|.|:|||.:||||||||||:||||||||||||||||||||||||:|:|||||||
Zfish   151 LERLHEFDTEQGAIDGLIASNVGDSTLADLMDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGR 215

Human   219 YGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLIT 283
            |||||||.||||||||||||||||||||||||:||||:|||||||||:|||||||:|||||||||
Zfish   216 YGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLIT 280

Human   284 HYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNG 348
            ||||.||||||||...::....|.:..||||||.|||.|||||:|||||||||||||||||||:.
Zfish   281 HYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDL 345

Human   349 QCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWE 413
            |||||||||||.|:||.|||||||||:|||||||||||||||||.||||:|||||||||||||||
Zfish   346 QCCIADLGLAVTHTQSDNQLDVGNNPKVGTKRYMAPEVLDETIQTDCFDAYKRVDIWAFGLVLWE 410

Human   414 VARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECW 478
            :|||.:||||||:|||||||:|||||||:||||||||:||||.|||||||||||::|.|||||||
Zfish   411 IARRTISNGIVEEYKPPFYDLVPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECW 475

Human   479 YQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
            |||||||||||||||||.||.:||:|.||||
Zfish   476 YQNPSARLTALRIKKTLDKIHSSLEKGKTDC 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1	NP_001096.1	Activin_recp	37..103	CDD:395845	23/65 (35%)
		TGF_beta_GS	179..206	CDD:400699	25/26 (96%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	252/296 (85%)
acvr1l	NP_571420.1	Activin_recp	28..94	CDD:307282	24/66 (36%)
		TGF_beta_GS	176..203	CDD:312125	25/26 (96%)
		STKc_ACVR1_ALK1	199..496	CDD:271044	252/296 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	517	1.000	Domainoid score	I2525
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7
Inparanoid	1	1.050	676	1.000	Inparanoid score	I4518
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111967at7742
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		oto47230
orthoMCL	1	0.900	-	-		OOG6_107567
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5088
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.960